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Search life-sciences literature (45,103,589 articles, preprints and more)

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Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7.
Hu Y, Ma L, Wu M, Wong MS, Li B, Corral S, Yu Z, Nomanbhoy T, Alemayehu S, Fuller SR, Rosenblum JS, Rozenkrants N, Minimo LC, Ripka WC, Szardenings AK, Kozarich JW, Shreder KR
Bioorg Med Chem Lett, 15(19):4239-4242, 01 Oct 2005
Cited by: 15 articles | PMID: 16085416
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Inhibition of fructose-1,6-bisphosphatase by a new class of allosteric effectors.
Choe JY, Nelson SW, Arienti KL, Axe FU, Collins TL, Jones TK, Kimmich RD, Newman MJ, Norvell K, Ripka WC, Romano SJ, Short KM, Slee DH, Fromm HJ, Honzatko RB
J Biol Chem, 278(51):51176-51183, 06 Oct 2003
Cited by: 16 articles | PMID: 14530289
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Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
Andersen HS, Olsen OH, Iversen LF, Sørensen AL, Mortensen SB, Christensen MS, Branner S, Hansen TK, Lau JF, Jeppesen L, Moran EJ, Su J, Bakir F, Judge L, Shahbaz M, Collins T, Vo T, Newman MJ, Ripka WC, Møller NP
J Med Chem, 45(20):4443-4459, 01 Sep 2002
Cited by: 55 articles | PMID: 12238924
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Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity.
Slee DH, Romano SJ, Yu J, Nguyen TN, John JK, Raheja NK, Axe FU, Jones TK, Ripka WC
J Med Chem, 44(13):2094-2107, 01 Jun 2001
Cited by: 23 articles | PMID: 11405647
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High-throughput purification of compound libraries.
Ripka WC, Barker G, Krakover J
Drug Discov Today, 6(9):471-477, 01 May 2001
Cited by: 16 articles | PMID: 11344032
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New thrombin inhibitors in cardiovascular disease.
Ripka WC
Curr Opin Chem Biol, 1(2):242-253, 01 Aug 1997
Cited by: 15 articles | PMID: 9667850
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Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.
Levy OE, Semple JE, Lim ML, Reiner J, Rote WE, Dempsey E, Richard BM, Zhang E, Tulinsky A, Ripka WC, Nutt RF
J Med Chem, 39(23):4527-4530, 01 Nov 1996
Cited by: 17 articles | PMID: 8917638
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Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties.
Semple JE, Rowley DC, Brunck TK, Ha-Uong T, Minami NK, Owens TD, Tamura SY, Goldman EA, Siev DV, Ardecky RJ, Carpenter SH, Ge Y, Richard BM, Nolan TG, Håkanson K, Tulinsky A, Nutt RF, Ripka WC
J Med Chem, 39(23):4531-4536, 01 Nov 1996
Cited by: 26 articles | PMID: 8917639
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Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.
Krishnan R, Tulinsky A, Vlasuk GP, Pearson D, Vallar P, Bergum P, Brunck TK, Ripka WC
Protein Sci, 5(3):422-433, 01 Mar 1996
Cited by: 16 articles | PMID: 8868478 | PMCID: PMC2143369
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Characterisation of a novel series of aprotinin-derived anticoagulants. I. In vitro and pharmacological properties.
Stassen JM, Lambeir AM, Matthyssens G, Ripka WC, Nyström A, Sixma JJ, Vermylen J
Thromb Haemost, 74(2):646-654, 01 Aug 1995
Cited by: 20 articles | PMID: 8585001
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Modeling rhodopsin, a member of G-protein coupled receptors, by computer graphics. Interpretation of chemical shifts of fluorinated rhodopsins.
Mirzadegan T, Humblet C, Ripka WC, Colmenares LU, Liu RS
Photochem Photobiol, 56(6):883-893, 01 Dec 1992
Cited by: 3 articles | PMID: 1492134
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Computer modelling of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding.
Domenighini M, Montecucco C, Ripka WC, Rappuoli R
Mol Microbiol, 5(1):23-31, 01 Jan 1991
Cited by: 38 articles | PMID: 1901617
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Synthesis and NMR conformational analysis of a beta-turn mimic incorporated into gramicidin S. A general approach to evaluate beta-turn peptidomimetics.
Bach AC, Markwalder JA, Ripka WC
Int J Pept Protein Res, 38(4):314-323, 01 Oct 1991
Cited by: 7 articles | PMID: 1724663
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Molecular modeling in the design of phospholipase A2 inhibitors.
Ripka WC, Sipio WJ, Galbraith WG
J Cell Biochem, 40(3):279-286, 01 Jul 1989
Cited by: 5 articles | PMID: 2777907
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Study of the shape of the binding site of bovine opsin using 10-substituted retinal isomers.
Asato AE, Denny M, Matsumoto H, Mirzadegan T, Ripka WC, Crescitelli F, Liu RS
Biochemistry, 25(22):7021-7026, 01 Nov 1986
Cited by: 4 articles | PMID: 2948554
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Introduction of restriction enzyme sites in protein-coding DNA sequences by site-specific mutagenesis not affecting the amino acid sequence: a computer program.
Arentzen R, Ripka WC
Nucleic Acids Res, 12(1 pt 2):777-787, 01 Jan 1984
Cited by: 5 articles | PMID: 6320109 | PMCID: PMC321092
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4-Hydroxy-1,2,3,4-tetrahydroisoquinolines: potential reaction products of norepinephrine1,2.
Reden J, Ripka WC, Rice KC, Brossi A
Adv Exp Med Biol, 126:69-72, 01 Jan 1980
Cited by: 0 articles | PMID: 7405705
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