U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Multifocal hypointensity of cerebral white matter on MRI

MedGen UID:
1643542
•Concept ID:
C4703614
•
Finding
HPO: HP:0040332

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultifocal hypointensity of cerebral white matter on MRI

Professional guidelines

PubMed

Primary central nervous system lymphoma: Imaging features and differential diagnosis.
Ribas GA, de Mori LH, Freddi TAL, Oliveira LDS, de Souza SR, Corrêa DG
Neuroradiol J 2024 Dec;37(6):705-722. Epub 2024 May 4 doi: 10.1177/19714009241252625. PMID: 38703015Free PMC Article

Recent clinical studies

Etiology

High b-value diffusion-weighted imaging in progressive multifocal leukoencephalopathy in HIV patients.
Godi C, De Vita E, Tombetti E, Davagnanam I, Haddow L, Jäger HR
Eur Radiol 2017 Sep;27(9):3593-3599. Epub 2017 Feb 6 doi: 10.1007/s00330-017-4761-8. PMID: 28168372Free PMC Article
Use of quantitative susceptibility mapping (QSM) in progressive multifocal leukoencephalopathy.
Carra-Dalliere C, Menjot de Champfleur N, Deverdun J, Ayrignac X, Nerrant E, Makinson A, Casanova ML, Labauge P
J Neuroradiol 2016 Feb;43(1):6-10. Epub 2015 Oct 23 doi: 10.1016/j.neurad.2015.08.001. PMID: 26475668
Magnetic resonance imaging pattern in natalizumab-associated progressive multifocal leukoencephalopathy.
Yousry TA, Pelletier D, Cadavid D, Gass A, Richert ND, Radue EW, Filippi M
Ann Neurol 2012 Nov;72(5):779-87. doi: 10.1002/ana.23676. PMID: 23280794
Clinical and MRI characteristics of levamisole-induced leukoencephalopathy in 16 patients.
Xu N, Zhou W, Li S, Zhou G, Zhang N, Liang J
J Neuroimaging 2009 Oct;19(4):326-31. Epub 2009 Jan 29 doi: 10.1111/j.1552-6569.2008.00344.x. PMID: 19187474
Patterns of MRI lesions in CADASIL.
Chabriat H, Levy C, Taillia H, Iba-Zizen MT, Vahedi K, Joutel A, Tournier-Lasserve E, Bousser MG
Neurology 1998 Aug;51(2):452-7. doi: 10.1212/wnl.51.2.452. PMID: 9710018

Diagnosis

MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation.
Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
White matter abnormalities and iron deposition in prenatal mucolipidosis IV- fetal imaging and pathology.
Zerem A, Ben-Sira L, Vigdorovich N, Leibovitz Z, Fisher Y, Schiffmann R, Grishchuk Y, Misko AL, Orenstein N, Lev D, Lerman-Sagie T, Kidron D
Metab Brain Dis 2021 Oct;36(7):2155-2167. Epub 2021 May 8 doi: 10.1007/s11011-021-00742-3. PMID: 33963976
Cortical hypointensity in T2-weighted gradient-echo sequences in patients with progressive multifocal leukoencephalopathy.
López Sala P, Alberdi Aldasoro N, Zelaya Huerta MV, Bacaicoa Saralegui MC, Cabada Giadás T
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):59-66. Epub 2019 Jul 30 doi: 10.1016/j.rx.2019.06.003. PMID: 31375267
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
MR imaging, apparent diffusion coefficient and histopathological features of desmoplastic infantile tumors-own experience and review of the literature.
Jurkiewicz E, Grajkowska W, Nowak K, Kowalczyk P, Walecka A, Dembowska-Bagińska B
Childs Nerv Syst 2015 Feb;31(2):251-9. Epub 2014 Nov 22 doi: 10.1007/s00381-014-2593-2. PMID: 25416471

Therapy

Cortical hypointensity in T2-weighted gradient-echo sequences in patients with progressive multifocal leukoencephalopathy.
López Sala P, Alberdi Aldasoro N, Zelaya Huerta MV, Bacaicoa Saralegui MC, Cabada Giadás T
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):59-66. Epub 2019 Jul 30 doi: 10.1016/j.rx.2019.06.003. PMID: 31375267
Magnetic resonance imaging pattern in natalizumab-associated progressive multifocal leukoencephalopathy.
Yousry TA, Pelletier D, Cadavid D, Gass A, Richert ND, Radue EW, Filippi M
Ann Neurol 2012 Nov;72(5):779-87. doi: 10.1002/ana.23676. PMID: 23280794
A rational approach to PML for the clinician.
Calabrese L
Cleve Clin J Med 2011 Nov;78 Suppl 2:S38-41. doi: 10.3949/ccjm.78.s2.09. PMID: 22123934
Clinical and MRI characteristics of levamisole-induced leukoencephalopathy in 16 patients.
Xu N, Zhou W, Li S, Zhou G, Zhang N, Liang J
J Neuroimaging 2009 Oct;19(4):326-31. Epub 2009 Jan 29 doi: 10.1111/j.1552-6569.2008.00344.x. PMID: 19187474
Patterns of MRI lesions in CADASIL.
Chabriat H, Levy C, Taillia H, Iba-Zizen MT, Vahedi K, Joutel A, Tournier-Lasserve E, Bousser MG
Neurology 1998 Aug;51(2):452-7. doi: 10.1212/wnl.51.2.452. PMID: 9710018

Prognosis

MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation.
Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
Acute hemorrhagic leukoencephalitis in a COVID-19 patient-a case report with literature review.
Varadan B, Shankar A, Rajakumar A, Subramanian S, Sathya AC, Hakeem AR, Kalyanasundaram S
Neuroradiology 2021 May;63(5):653-661. Epub 2021 Feb 11 doi: 10.1007/s00234-021-02667-1. PMID: 33575849Free PMC Article
Cortical hypointensity in T2-weighted gradient-echo sequences in patients with progressive multifocal leukoencephalopathy.
López Sala P, Alberdi Aldasoro N, Zelaya Huerta MV, Bacaicoa Saralegui MC, Cabada Giadás T
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):59-66. Epub 2019 Jul 30 doi: 10.1016/j.rx.2019.06.003. PMID: 31375267
A rational approach to PML for the clinician.
Calabrese L
Cleve Clin J Med 2011 Nov;78 Suppl 2:S38-41. doi: 10.3949/ccjm.78.s2.09. PMID: 22123934
Patterns of MRI lesions in CADASIL.
Chabriat H, Levy C, Taillia H, Iba-Zizen MT, Vahedi K, Joutel A, Tournier-Lasserve E, Bousser MG
Neurology 1998 Aug;51(2):452-7. doi: 10.1212/wnl.51.2.452. PMID: 9710018

Clinical prediction guides

MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation.
Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD
AJNR Am J Neuroradiol 2021 Jun;42(6):1073-1079. Epub 2021 May 13 doi: 10.3174/ajnr.A7145. PMID: 33985948Free PMC Article
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
MR imaging, apparent diffusion coefficient and histopathological features of desmoplastic infantile tumors-own experience and review of the literature.
Jurkiewicz E, Grajkowska W, Nowak K, Kowalczyk P, Walecka A, Dembowska-Bagińska B
Childs Nerv Syst 2015 Feb;31(2):251-9. Epub 2014 Nov 22 doi: 10.1007/s00381-014-2593-2. PMID: 25416471
Adolescents with D-transposition of the great arteries repaired in early infancy demonstrate reduced white matter microstructure associated with clinical risk factors.
Rivkin MJ, Watson CG, Scoppettuolo LA, Wypij D, Vajapeyam S, Bellinger DC, DeMaso DR, Robertson RL Jr, Newburger JW
J Thorac Cardiovasc Surg 2013 Sep;146(3):543-9.e1. Epub 2013 Feb 1 doi: 10.1016/j.jtcvs.2012.12.006. PMID: 23375991Free PMC Article
Patterns of MRI lesions in CADASIL.
Chabriat H, Levy C, Taillia H, Iba-Zizen MT, Vahedi K, Joutel A, Tournier-Lasserve E, Bousser MG
Neurology 1998 Aug;51(2):452-7. doi: 10.1212/wnl.51.2.452. PMID: 9710018

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...