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Abnormal cerebral subcortex morphology

MedGen UID:: 866852
•Concept ID:: C4021207
•: Anatomical Abnormality

Synonyms:	Abnormality of the cerebral medulla; Abnormality of the cerebral subcortex

HPO:	HP:0010993

Definition

An abnormality of the cerebral subcortex. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal cerebral subcortex morphology

Abnormality of the nervous system
- Abnormal nervous system morphology
  - Morphological central nervous system abnormality
    - Abnormal brain morphology
      - Abnormal forebrain morphology
        Abnormal cerebral morphology
        Abnormal cerebral subcortex morphology
        Abnormal basal ganglia morphology
        Abnormal basal ganglia MRI signal intensity
        Focal T2 hyperintense basal ganglia lesion
        Focal T2 hypointense basal ganglia lesion
        T2 hypointense basal ganglia
        Abnormal corpus striatum morphology
        Abnormal caudate nucleus morphology
        Abnormal putamen morphology
        Degeneration of the striatum
        Striatal T2 hyperintensity
        Abnormal globus pallidus morphology
        Globus pallidus calcification
        Globus pallidus hypointensity on susceptibility-weighted imaging
        Basal ganglia edema
        Basal ganglia necrosis
        Bilateral basal ganglia lesions
        Cavitation of the basal ganglia
        Dysgenesis of the basal ganglia
        Large basal ganglia
        Neuronal loss in basal ganglia
        Small basal ganglia
        Status cribrosum
        Symmetric lesions of the basal ganglia
        Abnormal cerebral white matter morphology
        Abnormal corpus callosum morphology
        Abnormal length of corpus callosum
        Dysplastic corpus callosum
        Probst bundles
        Snowball lesion of corpus callosum
        Thick corpus callosum
        Thin corpus callosum
        Abnormal periventricular white matter morphology
        Periventricular leukomalacia
        Periventricular pseudocyst
        Abnormality of the anterior commissure
        Agenesis of the anterior commissure
        Hypoplastic anterior commissure
        Abnormality of the bed nucleus of stria terminalis
        Reduced volume of central subdivision of bed nucleus of stria terminalis
        Abnormality of the internal capsule
        Hypoplastic anterior limbs of the internal capsule
        Aplasia/Hypoplasia of the cerebral white matter
        Agenesis of cerebral white matter
        Cerebral white matter hypoplasia
        Cerebral white matter atrophy
        Diffuse swelling of cerebral white matter
        Diffuse white matter abnormalities
        Confluent hypointensity of cerebral white matter on MRI
        Focal white matter lesions
        Hyperintensity of cerebral white matter on MRI
        Confluent hyperintensity of cerebral white matter on MRI
        Deep cerebral white matter hyperintensities
        Focal hyperintensity of cerebral white matter on MRI
        Multifocal hyperintensity of cerebral white matter on MRI
        Periventricular white matter hyperintensities
        Hypointensity of cerebral white matter on MRI
        Deep white matter hypodensities
        Focal hypointensity of cerebral white matter on MRI
        Multifocal hypointensity of cerebral white matter on MRI
        Periventricular white matter hypodensities
        Multifocal cerebral white matter abnormalities
        Reduced cerebral white matter volume
        White mater abnormalities in the posterior periventricular region
        White matter globoid cells
        Cerebral subcortical cyst
        Recurrent subcortical infarcts
        Subcortical U fiber lesion

Recent clinical studies

Etiology

Different patterns of white matter lesions among patent foramen ovale, atherosclerotic cerebral small vessel disease and cerebral venous thrombosis.

Wu X, Klomparens K, Chen Z, Zhang M, Song S, Ding Y, Ji X, Meng R
J Thromb Thrombolysis 2022 May;53(4):911-925. Epub 2022 Jan 5 doi: 10.1007/s11239-021-02624-y. PMID: 34985685

Nonconvulsive status epilepticus after cessation of convulsive status epilepticus in pediatric intensive care unit patients.

Chen J, Xie L, Hu Y, Lan X, Jiang L
Epilepsy Behav 2018 May;82:68-73. Epub 2018 Mar 26 doi: 10.1016/j.yebeh.2018.02.008. PMID: 29587188

Differences in subcortical structures in young adolescents at familial risk for schizophrenia: a preliminary study.

Dougherty MK, Gu H, Bizzell J, Ramsey S, Gerig G, Perkins DO, Belger A
Psychiatry Res 2012 Nov 30;204(2-3):68-74. Epub 2012 Nov 10 doi: 10.1016/j.pscychresns.2012.04.016. PMID: 23146250 Free PMC Article

The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific.

Bartzokis G, Goldstein IB, Hance DB, Beckson M, Shapiro D, Lu PH, Edwards N, Mintz J, Bridge P
AJNR Am J Neuroradiol 1999 Oct;20(9):1628-35. PMID: 10543632 Free PMC Article

Subcortical low intensity in early cortical ischemia.

Ida M, Mizunuma K, Hata Y, Tada S
AJNR Am J Neuroradiol 1994 Aug;15(7):1387-93. PMID: 7526671 Free PMC Article

See all (9)

Diagnosis

An adult case of multiphasic disseminated encephalomyelitis manifesting with optic neuritis.

Yang HQ, Zhao WC, Feng SM, Ma JJ
Intern Med 2014;53(9):1011-5. Epub 2014 May 1 doi: 10.2169/internalmedicine.53.1257. PMID: 24785895

Canadian Association of Neuroscience Review: Respiratory control and behavior in humans: lessons from imaging and experiments of nature.

Moss IR
Can J Neurol Sci 2005 Aug;32(3):287-97. doi: 10.1017/s0317167100004157. PMID: 16225168

Stroke and restricted sensory syndromes.

Kim JS, Lee MC
Neuroradiology 1994 May;36(4):258-63. doi: 10.1007/BF00593254. PMID: 8065565

Subcortical low intensity in early cortical ischemia.

Ida M, Mizunuma K, Hata Y, Tada S
AJNR Am J Neuroradiol 1994 Aug;15(7):1387-93. PMID: 7526671 Free PMC Article

Alzheimer's disease: a correlative study.

Neary D, Snowden JS, Mann DM, Bowen DM, Sims NR, Northen B, Yates PO, Davison AN
J Neurol Neurosurg Psychiatry 1986 Mar;49(3):229-37. doi: 10.1136/jnnp.49.3.229. PMID: 2420941 Free PMC Article

See all (11)

Therapy

Neurosyphilis complicated with pial arteriovenous fistula: A rare case report.

Xu L, Han F
Medicine (Baltimore) 2019 Nov;98(45):e17770. doi: 10.1097/MD.0000000000017770. PMID: 31702628 Free PMC Article

Nonconvulsive status epilepticus after cessation of convulsive status epilepticus in pediatric intensive care unit patients.

Chen J, Xie L, Hu Y, Lan X, Jiang L
Epilepsy Behav 2018 May;82:68-73. Epub 2018 Mar 26 doi: 10.1016/j.yebeh.2018.02.008. PMID: 29587188

The incidence of T2-weighted MR imaging signal abnormalities in the brain of cocaine-dependent patients is age-related and region-specific.

Bartzokis G, Goldstein IB, Hance DB, Beckson M, Shapiro D, Lu PH, Edwards N, Mintz J, Bridge P
AJNR Am J Neuroradiol 1999 Oct;20(9):1628-35. PMID: 10543632 Free PMC Article

See all (3)

Prognosis

Different patterns of white matter lesions among patent foramen ovale, atherosclerotic cerebral small vessel disease and cerebral venous thrombosis.

Wu X, Klomparens K, Chen Z, Zhang M, Song S, Ding Y, Ji X, Meng R
J Thromb Thrombolysis 2022 May;53(4):911-925. Epub 2022 Jan 5 doi: 10.1007/s11239-021-02624-y. PMID: 34985685

Nonconvulsive status epilepticus after cessation of convulsive status epilepticus in pediatric intensive care unit patients.

Chen J, Xie L, Hu Y, Lan X, Jiang L
Epilepsy Behav 2018 May;82:68-73. Epub 2018 Mar 26 doi: 10.1016/j.yebeh.2018.02.008. PMID: 29587188

Late-onset Alexander disease with a V87L mutation in glial fibrillary acidic protein (GFAP) and calcifying lesions in the sub-cortex and cortex.

Suzuki H, Yoshida T, Kitada M, Ichihashi J, Sasayama H, Nishikawa Y, Mistui Y, Nakagawa M, Kusunoki S
J Neurol 2012 Mar;259(3):457-61. Epub 2011 Aug 7 doi: 10.1007/s00415-011-6201-z. PMID: 21822933

Clinical and pathologic features of two groups of patients with dementia with Lewy bodies: effect of coexisting Alzheimer-type lesion load.

Del Ser T, Hachinski V, Merskey H, Munoz DG
Alzheimer Dis Assoc Disord 2001 Jan-Mar;15(1):31-44. doi: 10.1097/00002093-200101000-00005. PMID: 11236823

Subcortical low intensity in early cortical ischemia.

Ida M, Mizunuma K, Hata Y, Tada S
AJNR Am J Neuroradiol 1994 Aug;15(7):1387-93. PMID: 7526671 Free PMC Article

See all (7)

Clinical prediction guides

Different patterns of white matter lesions among patent foramen ovale, atherosclerotic cerebral small vessel disease and cerebral venous thrombosis.

Wu X, Klomparens K, Chen Z, Zhang M, Song S, Ding Y, Ji X, Meng R
J Thromb Thrombolysis 2022 May;53(4):911-925. Epub 2022 Jan 5 doi: 10.1007/s11239-021-02624-y. PMID: 34985685

An adult case of multiphasic disseminated encephalomyelitis manifesting with optic neuritis.

Yang HQ, Zhao WC, Feng SM, Ma JJ
Intern Med 2014;53(9):1011-5. Epub 2014 May 1 doi: 10.2169/internalmedicine.53.1257. PMID: 24785895

The topography of plaques and tangles in Down's syndrome patients of different ages.

Mann DM, Yates PO, Marcyniuk B, Ravindra CR
Neuropathol Appl Neurobiol 1986 Sep-Oct;12(5):447-57. doi: 10.1111/j.1365-2990.1986.tb00053.x. PMID: 2946973

An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease.

Hardy JA, Mann DM, Wester P, Winblad B
Neurobiol Aging 1986 Nov-Dec;7(6):489-502. doi: 10.1016/0197-4580(86)90086-2. PMID: 2882432

Brain tumor with ipsilateral cerebral hemiatrophy in children.

Kwak R, Saso S, Onuma T, Suzuki J
J Neurosurg Sci 1979 Apr-Jun;23(2):141-52. PMID: 521847

See all (10)

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Abnormal cerebral subcortex morphology

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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