U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pulmonary large cell neuroendocrine carcinoma

MedGen UID:
233608
Concept ID:
C1334363
Neoplastic Process
Synonyms: Large Cell Lung Carcinoma with Neuroendocrine Differentiation; large cell lung carcinoma with neuroendocrine differentiation; Large Cell Lung Neuroendocrine Carcinoma; large cell lung neuroendocrine carcinoma; Large Cell Neuroendocrine Carcinoma of Lung; large cell neuroendocrine carcinoma of lung; Large Cell Neuroendocrine Carcinoma of the Lung; large cell neuroendocrine carcinoma of the lung; LCNEC of the Lung; LCNEC of the lung; Lung Large Cell Neuroendocrine Carcinoma; lung large cell neuroendocrine carcinoma; Pulmonary Large Cell Neuroendocrine Carcinoma; pulmonary large cell neuroendocrine carcinoma
 
Monarch Initiative: MONDO:0003960

Definition

A high grade carcinoma that arises from the lung and is characterized by the presence of large neuroendocrine cells. It usually has an aggressive clinical course. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Miyagawa-Hayashino A, Okada S, Takeda-Miyata N, Takashima Y, Yamada T, Takemura Y, Uchino J, Inoue M, Takayama K, Konishi E
Appl Immunohistochem Mol Morphol 2021 Apr 1;29(4):313-320. doi: 10.1097/PAI.0000000000000875. PMID: 33031101Free PMC Article
Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EM, Dingemans AC; PALGA-Group
Clin Cancer Res 2018 Jan 1;24(1):33-42. Epub 2017 Oct 24 doi: 10.1158/1078-0432.CCR-17-1921. PMID: 29066508

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Lowczak A, Kolasinska-Cwikla A, Osowiecka K, Glinka L, Palucki J, Rzepko R, Doboszynska A, Cwikla JB
Medicina (Kaunas) 2021 Jan 28;57(2) doi: 10.3390/medicina57020118. PMID: 33525370Free PMC Article
Han Y, Pang L, Huang J, Chen J
Ann Palliat Med 2020 Sep;9(5):3705-3709. doi: 10.21037/apm-20-1667. PMID: 33065807
Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EM, Dingemans AC; PALGA-Group
Clin Cancer Res 2018 Jan 1;24(1):33-42. Epub 2017 Oct 24 doi: 10.1158/1078-0432.CCR-17-1921. PMID: 29066508
Rekhtman N, Pietanza MC, Hellmann MD, Naidoo J, Arora A, Won H, Halpenny DF, Wang H, Tian SK, Litvak AM, Paik PK, Drilon AE, Socci N, Poirier JT, Shen R, Berger MF, Moreira AL, Travis WD, Rudin CM, Ladanyi M
Clin Cancer Res 2016 Jul 15;22(14):3618-29. Epub 2016 Mar 9 doi: 10.1158/1078-0432.CCR-15-2946. PMID: 26960398Free PMC Article
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Diagnosis

Yang L, Fan Y, Lu H
Pathol Oncol Res 2022;28:1610730. Epub 2022 Oct 11 doi: 10.3389/pore.2022.1610730. PMID: 36304941Free PMC Article
Han Y, Pang L, Huang J, Chen J
Ann Palliat Med 2020 Sep;9(5):3705-3709. doi: 10.21037/apm-20-1667. PMID: 33065807
Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EM, Dingemans AC; PALGA-Group
Clin Cancer Res 2018 Jan 1;24(1):33-42. Epub 2017 Oct 24 doi: 10.1158/1078-0432.CCR-17-1921. PMID: 29066508
Iyoda A, Hiroshima K, Nakatani Y, Fujisawa T
Ann Thorac Surg 2007 Aug;84(2):702-7. doi: 10.1016/j.athoracsur.2007.03.093. PMID: 17643676
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Therapy

Iida Y, Wakuda K, Kenmotsu H, Doshita K, Kodama H, Nishioka N, Miyawaki E, Miyawaki T, Mamesaya N, Kobayashi H, Omori S, Ko R, Ono A, Naito T, Murakami H, Sugino T, Gon Y, Takahashi T
Sci Rep 2024 Apr 1;14(1):7641. doi: 10.1038/s41598-024-58327-w. PMID: 38561461Free PMC Article
Wang Y, Chen Y, Yang Z, Qian F, Hu M, Lu J, Zhang Y, Zhang W, Wang K, Han B
Ann Surg Oncol 2022 Sep;29(9):5666-5678. Epub 2022 May 11 doi: 10.1245/s10434-022-11610-4. PMID: 35543906
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EM, Dingemans AC; PALGA-Group
Clin Cancer Res 2018 Jan 1;24(1):33-42. Epub 2017 Oct 24 doi: 10.1158/1078-0432.CCR-17-1921. PMID: 29066508
Derks JL, van Suylen RJ, Thunnissen E, den Bakker MA, Groen HJ, Smit EF, Damhuis RA, van den Broek EC, Speel EM, Dingemans AC; PALGA group
Eur Respir J 2017 Jun;49(6) Epub 2017 Jun 1 doi: 10.1183/13993003.01838-2016. PMID: 28572122Free PMC Article

Prognosis

Yang L, Fan Y, Lu H
Pathol Oncol Res 2022;28:1610730. Epub 2022 Oct 11 doi: 10.3389/pore.2022.1610730. PMID: 36304941Free PMC Article
Han Y, Pang L, Huang J, Chen J
Ann Palliat Med 2020 Sep;9(5):3705-3709. doi: 10.21037/apm-20-1667. PMID: 33065807
Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EM, Dingemans AC; PALGA-Group
Clin Cancer Res 2018 Jan 1;24(1):33-42. Epub 2017 Oct 24 doi: 10.1158/1078-0432.CCR-17-1921. PMID: 29066508
Iyoda A, Hiroshima K, Nakatani Y, Fujisawa T
Ann Thorac Surg 2007 Aug;84(2):702-7. doi: 10.1016/j.athoracsur.2007.03.093. PMID: 17643676
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Clinical prediction guides

Wan S, Shen Z, Hu S, Zhang L, Yu H, Chen Y, Wang J, Wang D, Zhang J, Zhang P
Ann Thorac Surg 2024 Aug;118(2):385-393. Epub 2024 Jan 17 doi: 10.1016/j.athoracsur.2024.01.002. PMID: 38242341
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Lowczak A, Kolasinska-Cwikla A, Osowiecka K, Glinka L, Palucki J, Rzepko R, Doboszynska A, Cwikla JB
Medicina (Kaunas) 2021 Jan 28;57(2) doi: 10.3390/medicina57020118. PMID: 33525370Free PMC Article
Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EM, Dingemans AC; PALGA-Group
Clin Cancer Res 2018 Jan 1;24(1):33-42. Epub 2017 Oct 24 doi: 10.1158/1078-0432.CCR-17-1921. PMID: 29066508
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...