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EGFR-related lung cancer(EGFR)

MedGen UID:
472093
Concept ID:
CN130014
Disease or Syndrome
Synonym: EGFR

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Vansteenkiste J
Expert Rev Anticancer Ther 2004 Feb;4(1):5-17. doi: 10.1586/14737140.4.1.5. PMID: 14748652

Curated

Westwood M, Joore M, Whiting P, van Asselt T, Ramaekers B, Armstrong N, Misso K, Severens J, Kleijnen J
Health Technol Assess 2014 May;18(32):1-166. doi: 10.3310/hta18320. PMID: 24827857Free PMC Article

Suggested Reading

PubMed

Pasche B, Grant SC
JAMA 2014 May 21;311(19):1975-6. doi: 10.1001/jama.2014.3742. PMID: 24846033

Recent clinical studies

Etiology

Cho BC, Lu S, Felip E, Spira AI, Girard N, Lee JS, Lee SH, Ostapenko Y, Danchaivijitr P, Liu B, Alip A, Korbenfeld E, Mourão Dias J, Besse B, Lee KH, Xiong H, How SH, Cheng Y, Chang GC, Yoshioka H, Yang JC, Thomas M, Nguyen D, Ou SI, Mukhedkar S, Prabhash K, D'Arcangelo M, Alatorre-Alexander J, Vázquez Limón JC, Alves S, Stroyakovskiy D, Peregudova M, Şendur MAN, Yazici O, Califano R, Gutiérrez Calderón V, de Marinis F, Passaro A, Kim SW, Gadgeel SM, Xie J, Sun T, Martinez M, Ennis M, Fennema E, Daksh M, Millington D, Leconte I, Iwasawa R, Lorenzini P, Baig M, Shah S, Bauml JM, Shreeve SM, Sethi S, Knoblauch RE, Hayashi H; MARIPOSA Investigators
N Engl J Med 2024 Oct 24;391(16):1486-1498. Epub 2024 Jun 26 doi: 10.1056/NEJMoa2403614. PMID: 38924756
Zhou C, Tang KJ, Cho BC, Liu B, Paz-Ares L, Cheng S, Kitazono S, Thiagarajan M, Goldman JW, Sabari JK, Sanborn RE, Mansfield AS, Hung JY, Boyer M, Popat S, Mourão Dias J, Felip E, Majem M, Gumus M, Kim SW, Ono A, Xie J, Bhattacharya A, Agrawal T, Shreeve SM, Knoblauch RE, Park K, Girard N; PAPILLON Investigators
N Engl J Med 2023 Nov 30;389(22):2039-2051. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2306441. PMID: 37870976
Yokouchi H, Nishihara H, Harada T, Ishida T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Higuchi M, Honjo O, Minami Y, Watanabe N, Goto A, Suzuki H, Dosaka-Akita H, Isobe H, Nishimura M, Munakata M
Oncotarget 2017 Jun 13;8(24):39711-39726. doi: 10.18632/oncotarget.14410. PMID: 28055980Free PMC Article
Chen CY, Jan CI, Pi WC, Wang WL, Yang PC, Wang TH, Karni R, Wang TC
Oncotarget 2016 Mar 29;7(13):16760-72. doi: 10.18632/oncotarget.7606. PMID: 26919236Free PMC Article
Wang S, An T, Duan J, Zhang L, Wu M, Zhou Q, Chen J, Zhuo M, Yang L, Wang Y, Bai H, Wang J
PLoS One 2013;8(3):e51021. Epub 2013 Mar 8 doi: 10.1371/journal.pone.0051021. PMID: 23520442Free PMC Article

Diagnosis

Mohan S, Hakami MA, Dailah HG, Khalid A, Najmi A, Zoghebi K, Halawi MA
Pathol Res Pract 2024 Jan;253:155016. Epub 2023 Dec 5 doi: 10.1016/j.prp.2023.155016. PMID: 38070221
Shen J, Liu G, Qi H, Xiang X, Shao J
Cell Death Dis 2023 Oct 9;14(10):657. doi: 10.1038/s41419-023-06194-0. PMID: 37813845Free PMC Article
Zhang P, Song E, Jiang M, Song Y
Int J Radiat Biol 2021;97(2):170-178. Epub 2020 Nov 12 doi: 10.1080/09553002.2021.1846817. PMID: 33164600
Zheng MM, Li YS, Tu HY, Jiang BY, Yang JJ, Zhou Q, Xu CR, Yang XR, Wu YL
J Thorac Oncol 2021 Feb;16(2):250-258. Epub 2020 Oct 26 doi: 10.1016/j.jtho.2020.10.008. PMID: 33122107
Chen CY, Yu ZY, Chuang YS, Huang RM, Wang TC
J Biomed Sci 2015 Jun 3;22(1):38. doi: 10.1186/s12929-015-0139-x. PMID: 26036303Free PMC Article

Therapy

Cho BC, Lu S, Felip E, Spira AI, Girard N, Lee JS, Lee SH, Ostapenko Y, Danchaivijitr P, Liu B, Alip A, Korbenfeld E, Mourão Dias J, Besse B, Lee KH, Xiong H, How SH, Cheng Y, Chang GC, Yoshioka H, Yang JC, Thomas M, Nguyen D, Ou SI, Mukhedkar S, Prabhash K, D'Arcangelo M, Alatorre-Alexander J, Vázquez Limón JC, Alves S, Stroyakovskiy D, Peregudova M, Şendur MAN, Yazici O, Califano R, Gutiérrez Calderón V, de Marinis F, Passaro A, Kim SW, Gadgeel SM, Xie J, Sun T, Martinez M, Ennis M, Fennema E, Daksh M, Millington D, Leconte I, Iwasawa R, Lorenzini P, Baig M, Shah S, Bauml JM, Shreeve SM, Sethi S, Knoblauch RE, Hayashi H; MARIPOSA Investigators
N Engl J Med 2024 Oct 24;391(16):1486-1498. Epub 2024 Jun 26 doi: 10.1056/NEJMoa2403614. PMID: 38924756
Zhou C, Tang KJ, Cho BC, Liu B, Paz-Ares L, Cheng S, Kitazono S, Thiagarajan M, Goldman JW, Sabari JK, Sanborn RE, Mansfield AS, Hung JY, Boyer M, Popat S, Mourão Dias J, Felip E, Majem M, Gumus M, Kim SW, Ono A, Xie J, Bhattacharya A, Agrawal T, Shreeve SM, Knoblauch RE, Park K, Girard N; PAPILLON Investigators
N Engl J Med 2023 Nov 30;389(22):2039-2051. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2306441. PMID: 37870976
Yu JJ, Zhou DD, Yang XX, Cui B, Tan FW, Wang J, Li K, Shang S, Zhang C, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Huang B, Hua F, Hu ZW
Nat Commun 2020 Jul 21;11(1):3660. doi: 10.1038/s41467-020-17385-0. PMID: 32694521Free PMC Article
London M, Gallo E
Cell Biol Int 2020 Jun;44(6):1267-1282. Epub 2020 Mar 17 doi: 10.1002/cbin.11340. PMID: 32162758
Aggarwal S, Patil S, Rohtagi N
Indian J Cancer 2017 Dec;54(Supplement):S15-S24. doi: 10.4103/ijc.IJC_510_17. PMID: 29292704

Prognosis

Yu JJ, Zhou DD, Yang XX, Cui B, Tan FW, Wang J, Li K, Shang S, Zhang C, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Huang B, Hua F, Hu ZW
Nat Commun 2020 Jul 21;11(1):3660. doi: 10.1038/s41467-020-17385-0. PMID: 32694521Free PMC Article
London M, Gallo E
Cell Biol Int 2020 Jun;44(6):1267-1282. Epub 2020 Mar 17 doi: 10.1002/cbin.11340. PMID: 32162758
Wang CI, Chen YY, Wang CL, Yu JS, Chang YS, Yu CJ
Oncotarget 2016 May 3;7(18):25432-42. doi: 10.18632/oncotarget.8170. PMID: 27009856Free PMC Article
Bronte G, Terrasi M, Rizzo S, Sivestris N, Ficorella C, Cajozzo M, Di Gaudio F, Gulotta G, Siragusa S, Gebbia N, Russo A
Front Biosci (Elite Ed) 2011 Jun 1;3(3):879-87. doi: 10.2741/e296. PMID: 21622099
Galleges Ruiz MI, Floor K, Steinberg SM, Grünberg K, Thunnissen FB, Belien JA, Meijer GA, Peters GJ, Smit EF, Rodriguez JA, Giaccone G
Br J Cancer 2009 Jan 13;100(1):145-52. Epub 2008 Dec 2 doi: 10.1038/sj.bjc.6604781. PMID: 19050706Free PMC Article

Clinical prediction guides

Cho BC, Lu S, Felip E, Spira AI, Girard N, Lee JS, Lee SH, Ostapenko Y, Danchaivijitr P, Liu B, Alip A, Korbenfeld E, Mourão Dias J, Besse B, Lee KH, Xiong H, How SH, Cheng Y, Chang GC, Yoshioka H, Yang JC, Thomas M, Nguyen D, Ou SI, Mukhedkar S, Prabhash K, D'Arcangelo M, Alatorre-Alexander J, Vázquez Limón JC, Alves S, Stroyakovskiy D, Peregudova M, Şendur MAN, Yazici O, Califano R, Gutiérrez Calderón V, de Marinis F, Passaro A, Kim SW, Gadgeel SM, Xie J, Sun T, Martinez M, Ennis M, Fennema E, Daksh M, Millington D, Leconte I, Iwasawa R, Lorenzini P, Baig M, Shah S, Bauml JM, Shreeve SM, Sethi S, Knoblauch RE, Hayashi H; MARIPOSA Investigators
N Engl J Med 2024 Oct 24;391(16):1486-1498. Epub 2024 Jun 26 doi: 10.1056/NEJMoa2403614. PMID: 38924756
Wang Y, Hu C, Yu H, Hu J, Zhou Z, Fu N, Huang X, Kong F, Wang W, Liu J
Lung Cancer 2024 Mar;189:107495. Epub 2024 Jan 28 doi: 10.1016/j.lungcan.2024.107495. PMID: 38335691
Mohan S, Hakami MA, Dailah HG, Khalid A, Najmi A, Zoghebi K, Halawi MA
Pathol Res Pract 2024 Jan;253:155016. Epub 2023 Dec 5 doi: 10.1016/j.prp.2023.155016. PMID: 38070221
Chung CT, Yeh KC, Lee CH, Chen YY, Ho PJ, Chang KY, Chen CH, Lai YK, Chen CT
Pharmacol Res 2020 Nov;161:105183. Epub 2020 Sep 5 doi: 10.1016/j.phrs.2020.105183. PMID: 32896579
Bronte G, Terrasi M, Rizzo S, Sivestris N, Ficorella C, Cajozzo M, Di Gaudio F, Gulotta G, Siragusa S, Gebbia N, Russo A
Front Biosci (Elite Ed) 2011 Jun 1;3(3):879-87. doi: 10.2741/e296. PMID: 21622099

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • Westwood et al., 2014
      Epidermal growth factor receptor tyrosine kinase (EGFR-TK) mutation testing in adults with locally advanced or metastatic non-small cell lung cancer: a systematic review and cost-effectiveness analysis.

    Consumer resources

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