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Lung cancer

MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
Synonyms: Lung cancer, somatic; Malignant tumor of lung
SNOMED CT: Malignant tumor of lung (363358000); Lung cancer (363358000)
 
Genes (locations): BRAF (7q34); CASP8 (2q33.1); CYP2A6 (19q13.2); EGFR (7p11.2); ERBB2 (17q12); ERCC6 (10q11.23); FASLG (1q24.3); IRF1 (5q31.1); KRAS (12p12.1); MAP3K8 (10p11.23); PIK3CA (3q26.32); PPP2R1B (11q23.1); PRKN (6q26); SLC22A18 (11p15.4)
 
Monarch Initiative: MONDO:0008903
OMIM®: 211980

Definition

A primary or metastatic malignant neoplasm involving the lung. [from NCI]

Clinical features

From HPO
Minimally invasive lung adenocarcinoma
MedGen UID:
2871
Concept ID:
C0007120
Neoplastic Process
Adenocarcinoma of the Bronchus.
Non-small cell lung carcinoma
MedGen UID:
40104
Concept ID:
C0007131
Neoplastic Process
A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.
Lung adenocarcinoma
MedGen UID:
57744
Concept ID:
C0152013
Neoplastic Process
A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Wang Q, Gümüş ZH, Colarossi C, Memeo L, Wang X, Kong CY, Boffetta P
J Thorac Oncol 2023 Jan;18(1):31-46. Epub 2022 Oct 12 doi: 10.1016/j.jtho.2022.10.002. PMID: 36243387Free PMC Article
Lamoth F, Calandra T
Eur Respir Rev 2022 Dec 31;31(166) Epub 2022 Nov 29 doi: 10.1183/16000617.0114-2022. PMID: 36450372Free PMC Article
Duma N, Santana-Davila R, Molina JR
Mayo Clin Proc 2019 Aug;94(8):1623-1640. doi: 10.1016/j.mayocp.2019.01.013. PMID: 31378236

Curated

UK NICE guideline NG122, Lung cancer: diagnosis and management, 2023

Recent clinical studies

Etiology

Li J, Tang M, Gao X, Tian S, Liu W
Commun Biol 2023 Oct 7;6(1):1019. doi: 10.1038/s42003-023-05408-7. PMID: 37805623Free PMC Article
Leiter A, Veluswamy RR, Wisnivesky JP
Nat Rev Clin Oncol 2023 Sep;20(9):624-639. Epub 2023 Jul 21 doi: 10.1038/s41571-023-00798-3. PMID: 37479810
Oliver AL
Surg Clin North Am 2022 Jun;102(3):335-344. Epub 2022 Apr 21 doi: 10.1016/j.suc.2021.12.001. PMID: 35671760
Bade BC, Dela Cruz CS
Clin Chest Med 2020 Mar;41(1):1-24. doi: 10.1016/j.ccm.2019.10.001. PMID: 32008623
Mao Y, Yang D, He J, Krasna MJ
Surg Oncol Clin N Am 2016 Jul;25(3):439-45. doi: 10.1016/j.soc.2016.02.001. PMID: 27261907

Diagnosis

Leiter A, Veluswamy RR, Wisnivesky JP
Nat Rev Clin Oncol 2023 Sep;20(9):624-639. Epub 2023 Jul 21 doi: 10.1038/s41571-023-00798-3. PMID: 37479810
Lee E, Kazerooni EA
Semin Respir Crit Care Med 2022 Dec;43(6):839-850. Epub 2022 Nov 28 doi: 10.1055/s-0042-1757885. PMID: 36442474
Pei Q, Luo Y, Chen Y, Li J, Xie D, Ye T
Clin Chem Lab Med 2022 Nov 25;60(12):1974-1983. Epub 2022 Jun 30 doi: 10.1515/cclm-2022-0291. PMID: 35771735
Jones GS, Baldwin DR
Clin Med (Lond) 2018 Apr 1;18(Suppl 2):s41-s46. doi: 10.7861/clinmedicine.18-2-s41. PMID: 29700092Free PMC Article
Rodriguez-Canales J, Parra-Cuentas E, Wistuba II
Cancer Treat Res 2016;170:25-46. doi: 10.1007/978-3-319-40389-2_2. PMID: 27535388

Therapy

Deutsch JS, Cimino-Mathews A, Thompson E, Provencio M, Forde PM, Spicer J, Girard N, Wang D, Anders RA, Gabrielson E, Illei P, Jedrych J, Danilova L, Sunshine J, Kerr KM, Tran M, Bushong J, Cai J, Devas V, Neely J, Balli D, Cottrell TR, Baras AS, Taube JM
Nat Med 2024 Jan;30(1):218-228. Epub 2023 Oct 30 doi: 10.1038/s41591-023-02660-6. PMID: 37903504Free PMC Article
Milano G, Innocenti F, Minami H
Cancer Sci 2022 Jul;113(7):2224-2231. Epub 2022 May 26 doi: 10.1111/cas.15377. PMID: 35445479Free PMC Article
Guerra-Martín MD, Tejedor-Bueno MS, Correa-Casado M
Int J Environ Res Public Health 2021 Jan 24;18(3) doi: 10.3390/ijerph18031017. PMID: 33498883Free PMC Article
Novello S, Vavalà T
Future Oncol 2008 Oct;4(5):705-16. doi: 10.2217/14796694.4.5.705. PMID: 18922127
Lippman SM, Benner SE, Hong WK
J Clin Oncol 1994 Apr;12(4):851-73. doi: 10.1200/JCO.1994.12.4.851. PMID: 8151328

Prognosis

Siegel RL, Miller KD, Fuchs HE, Jemal A
CA Cancer J Clin 2021 Jan;71(1):7-33. Epub 2021 Jan 12 doi: 10.3322/caac.21654. PMID: 33433946
Santucci C, Carioli G, Bertuccio P, Malvezzi M, Pastorino U, Boffetta P, Negri E, Bosetti C, La Vecchia C
Eur J Cancer Prev 2020 Sep;29(5):367-381. doi: 10.1097/CEJ.0000000000000594. PMID: 32740162
Siegel RL, Miller KD, Jemal A
CA Cancer J Clin 2020 Jan;70(1):7-30. Epub 2020 Jan 8 doi: 10.3322/caac.21590. PMID: 31912902
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A
CA Cancer J Clin 2018 Nov;68(6):394-424. Epub 2018 Sep 12 doi: 10.3322/caac.21492. PMID: 30207593
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842

Clinical prediction guides

Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L; IASLC Pathology Committee
Cancer Cytopathol 2019 May;127(5):325-339. Epub 2019 May 3 doi: 10.1002/cncy.22137. PMID: 31050216Free PMC Article
Zukotynski KA, Gerbaudo VH
PET Clin 2017 Jan;12(1):53-62. Epub 2016 Sep 10 doi: 10.1016/j.cpet.2016.08.008. PMID: 27863566
Bashir U, Siddique MM, Mclean E, Goh V, Cook GJ
AJR Am J Roentgenol 2016 Sep;207(3):534-43. Epub 2016 Jun 15 doi: 10.2214/AJR.15.15864. PMID: 27305342
Harders SW, Balyasnikowa S, Fischer BM
Clin Physiol Funct Imaging 2014 Sep;34(5):340-55. Epub 2013 Dec 1 doi: 10.1111/cpf.12104. PMID: 24289258Free PMC Article
Brunelli A, Kim AW, Berger KI, Addrizzo-Harris DJ
Chest 2013 May;143(5 Suppl):e166S-e190S. doi: 10.1378/chest.12-2395. PMID: 23649437

Recent systematic reviews

Polański J, Świątoniowska-Lonc N, Kołaczyńska S, Chabowski M
Nutrients 2023 Mar 19;15(6) doi: 10.3390/nu15061477. PMID: 36986207Free PMC Article
Cabrera-Sanchez J, Cuba V, Vega V, Van der Stuyft P, Otero L
Eur Respir Rev 2022 Sep 30;31(165) Epub 2022 Jul 27 doi: 10.1183/16000617.0025-2022. PMID: 35896272Free PMC Article
Himbert C, Klossner N, Coletta AM, Barnes CA, Wiskemann J, LaStayo PC, Varghese TK Jr, Ulrich CM
Crit Rev Oncol Hematol 2020 Dec;156:103086. Epub 2020 Sep 13 doi: 10.1016/j.critrevonc.2020.103086. PMID: 33038630Free PMC Article
Toumazis I, Bastani M, Han SS, Plevritis SK
Lung Cancer 2020 Sep;147:154-186. Epub 2020 Jul 12 doi: 10.1016/j.lungcan.2020.07.007. PMID: 32721652
Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, Vineis P, Forastiere F, Saldiva P, Yorifuji T, Loomis D
Environ Health Perspect 2014 Sep;122(9):906-11. Epub 2014 Jun 6 doi: 10.1289/ehp/1408092. PMID: 24911630Free PMC Article

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