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ONTOLOGY REPORT - ANNOTATIONS

Term:histone H3K27 trimethyltransferase activity
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Accession:GO:0140951 term browser browse the term
Definition:Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3.
Synonyms:exact_synonym: histone H3-K27 trimethylase activity;   histone H3K27 mono/di/trimethylase activity;   histone H3K27 trimethylase activity;   histone lysine N-trimethyltransferase activity (H3-K27 specific)
 broad_synonym: histone H3-K27 trimethylation;   histone H3K27 trimethylation
 xref: RHEA:60292


show annotations for term's descendants           Sort by:
histone H3K27 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Nsd3 nuclear receptor binding SET domain protein 3 enables ISO (PMID:16682010) RGD PMID:16682010 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20627
    catalytic activity 6029
      catalytic activity, acting on a protein 2508
        protein methyltransferase activity 104
          protein-lysine N-methyltransferase activity 69
            histone H3K27 methyltransferase activity 6
              histone H3K27 trimethyltransferase activity 3
Path 2
Term Annotations click to browse term
  molecular_function 20627
    catalytic activity 6029
      transferase activity 2396
        transferase activity, transferring one-carbon groups 213
          methyltransferase activity 203
            S-adenosylmethionine-dependent methyltransferase activity 169
              lysine N-methyltransferase activity 69
                protein-lysine N-methyltransferase activity 69
                  histone H3K27 methyltransferase activity 6
                    histone H3K27 trimethyltransferase activity 3
paths to the root