Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:histone H3K4 trimethyltransferase activity
go back to main search page
Accession:GO:0140999 term browser browse the term
Definition:Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3.
Synonyms:exact_synonym: histone H3K4 trimethylase activity;   histone lysine N-trimethyltransferase activity (H3-K4 specific)
 broad_synonym: histone H3-K4 trimethylation;   histone H3K4 trimethylation
 xref: EC:2.1.1.354;   RHEA:60260


show annotations for term's descendants           Sort by:
histone H3K4 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmt2a lysine methyltransferase 2A enables ISO (PMID:20861184) RGD PMID:20861184 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Kmt2b lysine methyltransferase 2B enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:85,821,700...85,840,987
Ensembl chr 1:85,821,753...85,841,326 		JBrowse link
G Kmt2d lysine methyltransferase 2D enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325 		JBrowse link
G Prdm9 PR/SET domain 9 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652 		JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:33,395,963...33,421,671
Ensembl chr12:33,396,120...33,426,934 		JBrowse link
G Smyd2 SET and MYND domain containing 2 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr13:101,425,270...101,466,576
Ensembl chr13:101,425,273...101,466,576 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20627
    catalytic activity 6029
      catalytic activity, acting on a protein 2508
        protein methyltransferase activity 104
          protein-lysine N-methyltransferase activity 69
            histone H3K4 methyltransferase activity 17
              histone H3K4 trimethyltransferase activity 6
Path 2
Term Annotations click to browse term
  molecular_function 20627
    catalytic activity 6029
      transferase activity 2396
        transferase activity, transferring one-carbon groups 213
          methyltransferase activity 203
            S-adenosylmethionine-dependent methyltransferase activity 169
              lysine N-methyltransferase activity 69
                protein-lysine N-methyltransferase activity 69
                  histone H3K4 methyltransferase activity 17
                    histone H3K4 trimethyltransferase activity 6
paths to the root