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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315035
Species: Mus musculus
RGD Object: Gene
Symbol: Car9
Name: carbonic anhydrase 9
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Car9affects methylationISOCA9 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CA9 promoterPMID:27901495
Car9decreases expressionISOCA9 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CA9 mRNAPMID:20228066 PMID:35870112
Car9decreases methylationISOCA9 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of CA9 exonPMID:27901495
Car9multiple interactionsISOCA9 (Homo sapiens)6480464CTDBenzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]; Benzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]PMID:20228066
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