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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315035
Species: Mus musculus
RGD Object: Gene
Symbol: Car9
Name: carbonic anhydrase 9
Acc ID: CHEBI:3087
Term: betulinic acid
Definition: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.
Chemical ID: MESH:C002070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Car9decreases activityISOCA9 (Homo sapiens)6480464CTDBetulinic Acid analog results in decreased activity of CA9 proteinPMID:29454615
Car9multiple interactionsISOCA9 (Homo sapiens)6480464CTDBetulinic Acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]PMID:26540049
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