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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315035
Species: Mus musculus
RGD Object: Gene
Symbol: Car9
Name: carbonic anhydrase 9
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Car9increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of CAR9 mRNAPMID:24265542
Car9multiple interactionsEXP 6480464CTD3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [cobaltous chloride results in increased expression of CAR9 mRNA]PMID:24265542
Car9increases expressionISOCar9 (Rattus norvegicus)6480464CTDcobaltous chloride results in increased expression of CAR9 mRNAPMID:24386269
Car9increases expressionISOCA9 (Homo sapiens)6480464CTDcobaltous chloride results in increased expression of CA9 mRNA; cobaltous chloride results in increased expression of CA9 proteinPMID:19376846 PMID:19502547 PMID:19808899 PMID:20105288 PMID:20228066 PMID:20526721 PMID:22202117 PMID:24299737 PMID:24842335 PMID:25351418
Car9multiple interactionsISOCA9 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]; ARNT gene mutant form inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]; Benzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]; Benzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]; PTEN protein promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]; triptolide inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]; zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]PMID:19808899 PMID:20228066 PMID:22202117 PMID:24299737 PMID:24842335
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