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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315035
Species: Mus musculus
RGD Object: Gene
Symbol: Car9
Name: carbonic anhydrase 9
Acc ID: CHEBI:95082
Term: molibresib
Definition: A member of the class of triazolobenzodiazepine that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine substituted by methyl, 2-(ethylamino)-2-oxoethyl, 4-chlorophenyl, and methoxy groups at positions 1, 4S, 6, and 8, respectively. It is an orally bioavailable inhibitor of BET family of proteins that has demonstrated antitumour activity in preclinical models of solid and hematologic malignancies.
Chemical ID: MESH:C554645
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Car9decreases expressionISOCA9 (Homo sapiens)6480464CTDmolibresib results in decreased expression of CA9 mRNAPMID:27292261
Car9multiple interactionsISOCA9 (Homo sapiens)6480464CTDmolibresib inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]PMID:27292261
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