RGD Reference Report - Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. - Rat Genome Database

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Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer.

Authors: Niemelä, Anssi M  Hynninen, Piritta  Mecklin, Jukka-Pekka  Kuopio, Teijo  Kokko, Antti  Aaltonen, Lauri  Parkkila, Anna-Kaisa  Pastorekova, Silvia  Pastorek, Jaromir  Waheed, Abdul  Sly, William S  Orntoft, Torben F  Kruhøffer, Mogens  Haapasalo, Hannu  Parkkila, Seppo  Kivelä, Antti J 
Citation: Niemelä AM, etal., Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1760-6. doi: 10.1158/1055-9965.EPI-07-0080.
RGD ID: 155226867
Pubmed: PMID:17855694   (View Abstract at PubMed)
DOI: DOI:10.1158/1055-9965.EPI-07-0080   (Journal Full-text)

Carbonic anhydrase (CA) II, CA IX, and CA XII are expressed in various neoplasias and have been linked to tumorigenesis. We examined their expression in three different groups of colorectal cancer [i.e., microsatellite stable (MSS), microsatellite instable (MSI), and hereditary nonpolyposis colorectal cancer (HNPCC)]. First, we analyzed gene expression profiles of 113 specimens by a microarray method to study the expression of various CA isozymes in the subgroups of colorectal cancer. The results indicated that mRNAs for CA II and CA XII are down-regulated and CA IX mRNA is up-regulated in all three tumor categories when compared with the normal tissue. The up-regulation of CA IX was greatest in the HNPCC group. For more information, 77 specimens were immunohistochemically stained to study the levels of CA II, CA IX, and CA XII. Immunohistochemical analyses further confirmed that the subgroups express CA II, CA IX, and CA XII differentially, and the HNPCC tumors express high levels of CA IX. Expression of these CAs did not correlate to Dukes stage or grade of differentiation. Our results show that CAs are differentially expressed in the subgroups of colorectal cancer, and CA IX expression seems to be very high in most cases of HNPCC. CA IX could be a potential diagnostic and therapeutic target in HNPCC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CA12HumanLynch syndrome  IEP protein:decreased expression:colorectumRGD 
CA2HumanLynch syndrome  IEP protein:decreased expression:colorectumRGD 
CA9HumanLynch syndrome  IEP protein:increased expression:colorectumRGD 
Car12RatLynch syndrome  ISOCA12 (Homo sapiens)protein:decreased expression:colorectumRGD 
Car12MouseLynch syndrome  ISOCA12 (Homo sapiens)protein:decreased expression:colorectumRGD 
Car2RatLynch syndrome  ISOCA2 (Homo sapiens)protein:decreased expression:colorectumRGD 
Car2MouseLynch syndrome  ISOCA2 (Homo sapiens)protein:decreased expression:colorectumRGD 
Car9RatLynch syndrome  ISOCA9 (Homo sapiens)protein:increased expression:colorectumRGD 
Car9MouseLynch syndrome  ISOCA9 (Homo sapiens)protein:increased expression:colorectumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Car12  (carbonic anhydrase 12)
Car2  (carbonic anhydrase 2)
Car9  (carbonic anhydrase 9)

Genes (Mus musculus)
Car12  (carbonic anhydrase 12)
Car2  (carbonic anhydrase 2)
Car9  (carbonic anhydrase 9)

Genes (Homo sapiens)
CA12  (carbonic anhydrase 12)
CA2  (carbonic anhydrase 2)
CA9  (carbonic anhydrase 9)


Additional Information