We put forward Machine Learning methods to predict the decodability of a received message before the end of the actual transmission in an Early Hybrid Automatic Repeat reQuest (E-HARQ) feedback scheme. Here we focus on a single retransmission setting for ultra-reliable and low-latency communication (URLLC) and demonstrate how more elaborate classification approaches can significantly improve the effective bit error rate towards the URLLC requirement of 10 ^-5 with only small latency overhead. We stress the importance of a careful determination of the classifier's working point and discuss appropriate ways of discriminating between different classifiers. We demonstrate the feasibility of our procedure for different signal-to-noise ratios as well as subcode lengths and discuss practical implications of our findings.