Ergokalciferol

Ergokalciferol
	(3β,5Z,7E,22E)-9,10-sekoergosta-5,7,10(19),22-tetraen-3-ol
Drugi nazivi	Drisdol, Calcidol
Identifikacija
CAS registarski broj	50-14-6
PubChem	5280793
ChemSpider	4444351
UNII	VS041H42XC
DrugBank	DB00153
KEGG	C05441
ChEBI	28934
ChEMBL	CHEMBL1536
ATC code	A11CC01
Jmol-3D slike	Slika 1
SMILES
	O[C@@H]1CC(\C(=C)CC1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@@H](/C=C/[C@H](C)C(C)C)C)C
InChI
	InChI=1S/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1 ; Kod: MECHNRXZTMCUDQ-RKHKHRCZSA-N InChI=1/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1; Kod: MECHNRXZTMCUDQ-RKHKHRCZBW
Svojstva
Molekulska formula	C28H44O
Molarna masa	396,65 g/mol
Tačka topljenja	114–118 °C
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Ergokalciferol je forma vitamina D, poznata kao vitamin D₂. On je u prodaji pod raznim imenima uključujući: Deltalin, Drisdol, i Calcidol. Formira se iz viosterola kad ultraljubičasto svetlo aktivira ergosterol. Gljive su primarni prirodni izvor.

Ergokalciferol se može koristiti kao suplement vitamina D. Jedna klinička smernica iz 2011.^[6] ga smatra jednako efektivnim kao i holekalciferol (vitamin D₃), koji prirodno proizvodi koža pri izlaganju ultraljubičastom svetlu. Postoji konfliktna evidencija o tome u kojoj meri D₂ i D₃ imaju slično dejstvo u telu i da li su jednako aktivni. Neke studije sugerišu da je D₃ potentniji,^[7]^[8] dok druge iznose jednaku potentnost.^[6]^[9]^[10]

Uloga u Alchajmerovoj bolesti

Jedna nedavna studija je utvrdila da veoma niske nivoe vitamina D₂ kod pacijenata obolelih od Alchajmerove bolesti.^[11]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^6,0 ^6,1 Holick, M. F.; Binkley, N. C.; Bischoff-Ferrari, H. A.; Gordon, C. M.; Hanley, D. A.; Heaney, R. P.; Murad, M. H.; Weaver, C. M. (2011). „Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline”. Journal of Clinical Endocrinology & Metabolism 96 (7): 1911. DOI:10.1210/jc.2011-0385. PMID 21646368.
↑ Houghton, L.; Vieth, R. (2006). „The case against ergocalciferol (vitamin D2) as a vitamin supplement”. The American Journal of Clinical Nutrition 84 (4): 694–697. PMID 17023693.
↑ Trang, H. M.; Cole, D. E.; Rubin, L. A.; Pierratos, A.; Siu, S.; Vieth, R. (1998). „Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2”. The American journal of clinical nutrition 68 (4): 854–858. PMID 9771862.
↑ Holick Mf, B. R.; Biancuzzo, R. M.; Chen, T. C.; Klein, E. K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W. i dr.. (2007). „Vitamin D2 is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D”. Journal of Clinical Endocrinology & Metabolism 93 (3): 677–681. DOI:10.1210/jc.2007-2308. PMC 2266966. PMID 18089691.
↑ Biancuzzo, R. M.; Young, A.; Bibuld, D.; Cai, M. H.; Winter, M. R.; Klein, E. K.; Ameri, A.; Reitz, R. i dr.. (2010). „Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults”. American Journal of Clinical Nutrition 91 (6): 1621–1626. DOI:10.3945/ajcn.2009.27972. PMC 2869510. PMID 20427729.
↑ „Low 25OH Vitamin D2 Levels Found in Untreated Alzheimer's Patients, Compared to Acetylcholinesterase-Inhibitor Treated and Controls” Current Alzheimer Research 9 (9) 2012 DOI:10.2174/156720512803568975 ISSN 1567-2050

Spoljašnje veze

NIST Chemistry WebBook page for ergocalciferol

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[holick_guideline-6] 6,0 ^6,1 Holick, M. F.; Binkley, N. C.; Bischoff-Ferrari, H. A.; Gordon, C. M.; Hanley, D. A.; Heaney, R. P.; Murad, M. H.; Weaver, C. M. (2011). „Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline”. Journal of Clinical Endocrinology & Metabolism 96 (7): 1911. DOI:10.1210/jc.2011-0385. PMID 21646368.

[the_case_against_ergocalciferol-7] Houghton, L.; Vieth, R. (2006). „The case against ergocalciferol (vitamin D2) as a vitamin supplement”. The American Journal of Clinical Nutrition 84 (4): 694–697. PMID 17023693.

[trang-8] Trang, H. M.; Cole, D. E.; Rubin, L. A.; Pierratos, A.; Siu, S.; Vieth, R. (1998). „Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2”. The American journal of clinical nutrition 68 (4): 854–858. PMID 9771862.

[holick-as_effective-9] Holick Mf, B. R.; Biancuzzo, R. M.; Chen, T. C.; Klein, E. K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W. i dr.. (2007). „Vitamin D2 is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D”. Journal of Clinical Endocrinology & Metabolism 93 (3): 677–681. DOI:10.1210/jc.2007-2308. PMC 2266966. PMID 18089691.

[orange_juice-10] Biancuzzo, R. M.; Young, A.; Bibuld, D.; Cai, M. H.; Winter, M. R.; Klein, E. K.; Ameri, A.; Reitz, R. i dr.. (2010). „Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults”. American Journal of Clinical Nutrition 91 (6): 1621–1626. DOI:10.3945/ajcn.2009.27972. PMC 2869510. PMID 20427729.

[11] „Low 25OH Vitamin D2 Levels Found in Untreated Alzheimer's Patients, Compared to Acetylcholinesterase-Inhibitor Treated and Controls” Current Alzheimer Research 9 (9) 2012 DOI:10.2174/156720512803568975 ISSN 1567-2050

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]