Receptor kinaznog umetnutog domena

Receptor kinaznog umetnutog domena‎ (tip III receptorske tirozinske kinaze)
	; Prikaz bazirna na 1VR2
Dostupne strukture
	1VR2, 1Y6A, 1Y6B, 1YWN, 2M59, 2OH4, 2P2H, 2P2I, 2QU5, 2QU6, 2RL5, 2X1W, 2X1X, 2XIR, 3B8Q, 3B8R, 3BE2, 3C7Q, 3CJF, 3CJG, 3CP9, 3CPB, 3CPC, 3DTW, 3EFL, 3EWH, 3KVQ, 3S35, 3S36, 3S37, 3U6J, 3V2A, 3V6B, 3VHE, 3VHK, 3VID, 3VNT, 3VO3, 4AG8, 4AGC, 4AGD, 4ASD, 4ASE
Identifikatori
Simboli	KDR; CD309; FLK1; VEGFR; VEGFR2
Vanjski ID	OMIM: 191306 MGI: 96683 HomoloGene: 55639 GeneCards: KDR Gene
EC broj	2.7.10.1
Ontologija gena
Molekulska funkcija	• aktivnost proteinske tirozinske kinaze; • aktivnost transmembranske receptorske proteinske tirozinske kinaze; • aktivnost receptorskog signalnog proteina tirozinske kinaze;
Ćelijska komponenta	• ekstracelularni region; • nukleus; • endozom;
Biološki proces	• angiogeneza; • vaskulogeneza; • pozitivna regulacija proteinske fosforilacije;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Receptor kinaznog umetnutog domena (KDR, tip III receptorske tirozinske kinaze, receptor 2 vakkularnog endotelnog faktora rasta, VEGFR-2, Flk1, fetalna jetrena kinaza 1) je VEGF receptor. KDR je ljudski gen koji kodira ovaj enzim. KDR se takođe označava sa CD309 (klaster diferencijacije 309).

Interakcije

Receptor kinaznog umetnutog domena formira interakcije sa SHC2,^[1] Aneksin A5^[2] i SHC1.^[3]^[4]

Povezano

Reference

↑ Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (April 2000). „The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells”. Biochem. J. (England) 347 (Pt 2): 501–9. DOI:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680.
↑ Wen, Y; Edelman J L; Kang T; Sachs G (May 1999). „Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1”. Biochem. Biophys. Res. Commun. (UNITED STATES) 258 (3): 713–21. DOI:10.1006/bbrc.1999.0678. ISSN 0006-291X. PMID 10329451.
↑ Zanetti, Adriana; Lampugnani Maria Grazia; Balconi Giovanna; Breviario Ferruccio; Corada Monica; Lanfrancone Luisa; Dejana Elisabetta (April 2002). „Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling”. Arterioscler. Thromb. Vasc. Biol. (United States) 22 (4): 617–22. DOI:10.1161/01.ATV.0000012268.84961.AD. PMID 11950700.
↑ D'Angelo, G; Martini J F; Iiri T; Fantl W J; Martial J; Weiner R I (May 1999). „16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells”. Mol. Endocrinol. (UNITED STATES) 13 (5): 692–704. DOI:10.1210/me.13.5.692. ISSN 0888-8809. PMID 10319320.

Literatura

Holmes K, Roberts OL, Thomas AM, Cross MJ. (October 2007). „Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.”. Cell Signal. 19 (10): 2003–2012. DOI:10.1016/j.cellsig.2007.05.013. PMID 17658244.
Petrova TV, Makinen T, Alitalo K (1999). „Signaling via vascular endothelial growth factor receptors.”. Exp. Cell Res. 253 (1): 117–30. DOI:10.1006/excr.1999.4707. PMID 10579917.
Sato Y, Kanno S, Oda N, et al. (2000). „Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction.”. Ann. N. Y. Acad. Sci. 902 (1): 201–5; discussion 205–7. DOI:10.1111/j.1749-6632.2000.tb06314.x. PMID 10865839.
Zachary I, Gliki G (2001). „Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.”. Cardiovasc. Res. 49 (3): 568–81. DOI:10.1016/S0008-6363(00)00268-6. PMID 11166270.
Vené R, Benelli R, Noonan DM, Albini A (2001). „HIV-Tat dependent chemotaxis and invasion, key aspects of tat mediated pathogenesis.”. Clin. Exp. Metastasis 18 (7): 533–8. DOI:10.1023/A:1011991906685. PMID 11688957.
Lenton K (2003). „VEGFR-2 (KDR/Flk-1).”. J. Biol. Regul. Homeost. Agents 16 (3): 227–32. PMID 12456025.
Matsumoto T, Mugishima H (2006). „Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis.”. J. Atheroscler. Thromb. 13 (3): 130–5. DOI:10.5551/jat.13.130. PMID 16835467.

Vanjske veze

MeSH Kinase+insert+domain+receptor

[pmid10749680-1] Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (April 2000). „The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells”. Biochem. J. (England) 347 (Pt 2): 501–9. DOI:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680.

[pmid10329451-2] Wen, Y; Edelman J L; Kang T; Sachs G (May 1999). „Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1”. Biochem. Biophys. Res. Commun. (UNITED STATES) 258 (3): 713–21. DOI:10.1006/bbrc.1999.0678. ISSN 0006-291X. PMID 10329451.

[pmid11950700-3] Zanetti, Adriana; Lampugnani Maria Grazia; Balconi Giovanna; Breviario Ferruccio; Corada Monica; Lanfrancone Luisa; Dejana Elisabetta (April 2002). „Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling”. Arterioscler. Thromb. Vasc. Biol. (United States) 22 (4): 617–22. DOI:10.1161/01.ATV.0000012268.84961.AD. PMID 11950700.

[pmid10319320-4] D'Angelo, G; Martini J F; Iiri T; Fantl W J; Martial J; Weiner R I (May 1999). „16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells”. Mol. Endocrinol. (UNITED STATES) 13 (5): 692–704. DOI:10.1210/me.13.5.692. ISSN 0888-8809. PMID 10319320.

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p r u Proteini: klasteri diferencijacije (vidi isto spisak ljudskih klastera diferencijacije)
1-50	CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
51-100	CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150	CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200	CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250	CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
251-300	CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350	CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350

p r u Receptori: Receptori faktora rasta
Nervni faktori rasta	niski afinitet/p75 - visok afinitet Trk (TrkA, TrkB, TrkC) - Cilijarni neurotrofni faktor
Somatomedin	Insulinu-sličan faktor rasta 1 - Insulinu-sličan faktor rasta 2
CSF	Stem ćelijski faktor - Eritropoietin
TGF put	TGF-beta (1, 2) - Aktivin (1, 2) - Bone morfogenetski protein (1, 2)
Drugi	Hepatocitni faktor rasta - ErbB/Epidermalni faktor rasta - Fibroblast faktor rasta (1, 2, 3, 4) - Trombocit-izvedeni faktor rasta (A, B) - VEGF (1, 2, 3)
vidi isto Faktori rasta
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)