Makrofagni inflamatorni protein

Hemokin (C-C motiv) ligand 4
Identifikatori
Simbol	CCL4
Alt. simboli	SCYA4, MIP-1β, LAG1
Entrez	6351
HUGO	10630
OMIM	182284
PDB	1HUM
RefSeq	NM_002984
UniProt	P13236
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Lokus	Hromozom 17 q21-q23

Hemokine (C-C motiv) ligand 3
Identifikatori
Simbol	CCL3
Alt. simboli	SCYA3, MIP-1α
Entrez	6348
HUGO	10627
OMIM	182283
PDB	1B50
RefSeq	NM_002983
UniProt	P10147
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Lokus	Hromozom 17 q12

Makrofagni inflamatorni proteini (MIP) pripadaju familiji citokina poznatih kao hemokini. Kod ljudi, postoje dva glavna oblika, MIP-1α i MIP-1β koja se zvanično nazivaju CCL3 i CCL4, respektivno. Ova dva hemokina su značajni faktori koje proizvode makrofage nakon stimulacije sa bakterijskim endotoksinima.^[1] Oni aktiviraju ljudske granulocite (neutrofile, eozinofile i bazofile), što može da dovede do akutne neutrofilske inflamacije. Oni takođe indukuju sintezu i oslobađanje drugih proinflamatornih citokina kao što su interleukin 1 (IL-1), IL-6 i TNF-α iz fibroblasta i makrofaga. Geni za CCL3 i CCL4 su locirani na ljudskom hromozomu 17.^[2]^[3]

Povezano

Hemokin

Reference

↑ Sherry et al. (1988). „Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1-beta”. J. Exp. Med. 168: 2251-2259.
↑ Irving et al. (1990). „Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q”. Nucleic Acids Res 18: 3261-3270.
↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

Spoljašnje veze

[1] Sherry et al. (1988). „Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1-beta”. J. Exp. Med. 168: 2251-2259.

[2] Irving et al. (1990). „Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q”. Nucleic Acids Res 18: 3261-3270.

[3] Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

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