Lyrically, I Am Nemesis is a continuation of the band's last record, Say Hello to Tragedy, and focuses on controversial and often overlooked world issues. The guitarist Marc Görtz told: "The album breaks new soil without forgetting our roots. There are new influences such as shimmering guitar melodies and technical grooves with Meshuggah-like heaviness. It was important to us to have an elaborate album without any fillers. Additionally, the sound of the album is the best we've ever had by far: it is heavy and brutal without being chaotic."[3]
Marcus Bischoff of Heaven Shall Burn and Mitch Lucker of Suicide Silence are confirmed as guest vocals.
The first track off the album "Memorial" premiered on 19 December, as a music video on the website Metal Hammer Germany.,[3] and the second single "Dein R3.ich" was released on 6 January 2012. The album entered the German Media Control chart at No. 21. Caliban promoted the album through their "Get Infected" Tour 2012 with support of Winds Of Plague, We Butter the Bread with Butter, Eyes Set To Kill and Attila which started off on 2 February in Karlsruhe, Germany.[3] Due to personal reasons All Shall Perish had to cancel the tour, they were replaced by Winds of Plague.