Sodium astatide
| |||
| Names | |||
|---|---|---|---|
| Preferred IUPAC name
Sodium astatide | |||
| Identifiers | |||
3D model (JSmol)
|
|||
| |||
| Properties | |||
| NaAt | |||
| Thermochemistry | |||
Std enthalpy of
formation (ΔfH⦵298) |
−257 kJ/mol (estimated)[1] | ||
| Related compounds | |||
Related compounds
|
Magnesium astatide | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |||
Sodium astatide is a binary inorganic compound of sodium and astatine with the chemical formula NaAt.[2][3]
Synthesis
[edit]Sodium astatide solution has been prepared by distilling astatine from the bismuth alpha-ray target where it was prepared, dissolving in sodium bicarbonate solution, and reducing At+ and At3+ ions with ascorbic acid.[4]
Uses
[edit]Sodium astatide has been proposed for use in radiation therapy to replace 131I.[5][4]
References
[edit]- ^ Burgers, Peter C.; Zeneyedpour, Lona; Luider, Theo M.; Holmes, John L. (2024). "Estimation of thermodynamic and physicochemical properties of the alkali astatides: On the bond strength of molecular astatine (At 2 ) and the hydration enthalpy of astatide (At − )". Journal of Mass Spectrometry. 59 (4). doi:10.1002/jms.5010. ISSN 1076-5174.
- ^ Watabe, Tadashi; Hosono, Makoto; Kinuya, Seigo; Yamada, Takahiro; Yanagida, Sachiko; Namba, Masao; Nakamura, Yoshihide (July 2021). "Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)". Annals of Nuclear Medicine. 35 (7): 753–766. doi:10.1007/s12149-021-01619-2. ISSN 1864-6433. PMC 8197710. PMID 33978932.
- ^ Ball, Philip (17 March 2020). "An affinity for astatine". Chemistry World. Retrieved 16 June 2023.
- ^ a b Y. Shirakami. "Preparation of [211At]-labeled sodium astatide (NaAt) by reducing with ascorbic acid for the treatment of thyroid cancer" (PDF). RIKEN Accel. Prog. Rep. 53: 171. Retrieved 16 June 2023.
- ^ "Breakthrough alpha-ray treatment of cancer without external radiation". EurekAlert!. Retrieved 16 June 2023.
