Talk:Ziprasidone/Archive 1

Archive 1

bioavailability with food

"Ziprasidone absorption is not optimally achieved when administered without food. Without a meal preceding dose, the bioavailability of the drug is reduced by approximately 50%." Since bioavailability is measured as a percentage, the 50% bit was very confusing for me. It could be taken as 60%->10% or 60%->30%; the sources make it clear that it's the 60%->30%. I'm very bad with wording, so I was wondering if someone could reword that for me! Thanks and happy editing! —Preceding unsigned comment added by 71.170.14.238 (talk) 15:47, 24 October 2009 (UTC)

adverse effects

please reference the heart attack statement that says it has been known to cause heart attacks —Preceding unsigned comment added by 71.103.107.40 (talk) 01:18, 15 September 2007 (UTC)

" (Geodon may alter the QT interval of heart I think I heard)~~johnericfranklin@rock.com~~ "About 1 in 10-20 (approximately) patient titrated up to high doses of Geodon (360mg a day) will show a significant improvment in cognition."

Geodon also lowers the seizure threshold, which is its big difference from Risperdal. That's definitely important. —Preceding unsigned comment added by 74.69.98.18 (talk) 04:48, 29 November 2007 (UTC)

Request for expansion

This is a "black box drug" in the USA because of prolonged QT syndrome, the only atypical antipsychotic to be labeled as such as far as I know. The main reason I'm asking this is because people need to be more aware- my doctor only mentioned it in passing, and I got the impression it was a very rare reaction. Suffice it to say I developed acquired Long QT Syndrome which went undetected for a long while until one day it apparently degenerated into Torsades de pointes while in the hospital for something unrelated. I nearly died and was shocked that it was a result of my Geodon. In short, while I'm no writer, I would highly appreciate it if someone wrote about the black box warning about cardiac arrythmias from Geodon. http://www.fda.gov/medWatch/safety/2002/geodon.htm - Source of information from FDA. 76.185.121.215 02:57, 1 August 2007 (UTC)

Talk: Ziprasidone 1st Section

I would like to see a reference to support this statement in the article. The effects of the atypical antipsychotics on cognition are widely debated, and IMO, are likely of minimal clinical significance. Secondly, no atypical has been conclusively shown to be more effective with regards to restoring or preserving cognitive functioning than any other atypical. While individual studies may suggest benefit of one agent over another, the data when viewed collectively is not clear cut. I aware of no conclusive evidence to make the statement that ziprasidone is better than olanzapine or risperidone in regards to preservation or restoration of cognitive functioning. The head to head data either does not exist or is not robust. Absent a reference supporting the statements made in the pharmacology section regarding cognition effects with ziprasidone, I am going to delete this information.

If anyone is aware of conclusive data supporting this statement I would be interested in seeing it.

Statement sounds largely speculative. A literature reference should definitely be cited, but the part about, "1 in 10-20" sounds a bit fishy to me. There's a big difference in the difference between "1 in 10" and "1 in 20" (either 5% or 10%). Dr. Cash 03:55, 21 August 2005 (UTC)

I have a problem with this sentence in the article: ("The medication can cause any conceivable side effect") Any conceivable side-effec??????? Including death, heart-attack, stroke, coma, itching, scratching and a runny nose????? This is non-sense I guess geodon causes many side-effects but hardly every side effect conceivable. Please remove or rewrite this sentence! Jeroen. — Preceding unsigned comment added by 131.174.88.53 (talk) 10:11, 17 August 2006

Ziprasidone generics in Europe

In some central and eastern european lands, a generic ziprasidone drug (trade name Zypsilan, manufactured by Krka d.d.) was launched in September 2008; it is an oral galenic (capsules), containig ziprasidone hydrogensulfate (instead of hydrochloride in Zeldox/Geodon capsules). See e.g. Public Assesment Report. Is it relevant enough to be mentioned in the article?--84.163.114.229 (talk) 01:31, 26 December 2008 (UTC)

I think that it is. 65.185.101.172 (talk) 05:19, 17 May 2010 (UTC)

Pharmacology

The term affinity seems meaningless in this context. Usually the terms agonist or antagonist are used with neurotransmitter medications of this sort. It is entirely unlcear whether this drug is (like) an agonist or antagonist. —Preceding unsigned comment added by 75.67.163.209 (talk) 22:07, 27 April 2009 (UTC)

I added the fact that it is an antagonist to the head of the section I believe you were refering to.--Metalhead94 (talk) 08:20, 18 June 2009 (UTC)

Geodon and Your Heart

Geodon made me have chest pains so bad I was writhing on the floor clenching my chest thinking I was having a heart attack. It has done something to me that is seemingly permanent. I have an insatiable desire for opium poppy now. I don't know how I know I need opium poppy because all I ever had in my life was codeine containing cough syrup as a child. Being given Geodon has given me weird experiences wherein I know for a certainty that the heart has a figurative mind of its own just as the Holy Scriptures says it does. Geodon took away my joy. What little joy I still had in my life Geodon took it away. I find myself craving the seed pods of opium poppy which I will grow myself somehow and juice the pods and add honey to it because I know it will give me joy in my heart and cure this malignant poison called Geodon. Besides the Holy Scriptures says YEHOVAH GOD gave man all plants bearing seed as FOOD in the book of Genesis chapter 1 verse 29. Any suggestions and information from someone knowledgeable would be appreciated. —Preceding unsigned comment added by 65.185.101.172 (talk) 05:18, 17 May 2010 (UTC)

First off, this is Wikipedia, not Yahoo answers. On the actual subject of the Heading, Geodon gave me Tachycardia. This is a documented side effect. See http://www.healthsquare.com/newrx/geo1590_2.htm. "Remember that Geodon can cause dangerous—even fatal—heartbeat irregularities. Warning signs include dizziness, palpitations, and fainting. Tell your doctor immediately if you experience any of these symptoms. Be careful to avoid drugs that prolong the QT interval of the heartbeat. Check with your doctor before combining any other medication with Geodon." I am listeing this in the adverse effects section. —Preceding unsigned comment added by 74.74.174.161 (talk) 03:32, 22 July 2010 (UTC)

There is a mistake: The half life is given as 7 hrs on the right table and 2-5 hrs in the text. —Preceding unsigned comment added by 64.118.209.205 (talk) 01:07, 18 December 2010 (UTC)