KEGG ENZYME: 1.2.1.106

ENZYME: 1.2.1.106

Entry

EC 1.2.1.106                Enzyme

Name

[amino-group carrier protein]-5-phospho-L-glutamate reductase;
lysY (gene name)

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

[amino-group carrier protein]-C-terminal-gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate:NADP+ 5-oxidoreductase (phosphorylating)

Reaction(IUBMB)

an [amino-group carrier protein]-C-terminal-gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate + phosphate + NADP+ = an [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + NADPH + H+ [RN:R10931]

Reaction(KEGG)

R10931

Substrate

[amino-group carrier protein]-C-terminal-gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate [CPD:C20950];
phosphate [CPD:C00009];
NADP+ [CPD:C00006]

Product

[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate [CPD:C20949];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme participates in an L-arginine biosynthesis pathway in certain species of archaea and bacteria. In some organisms the enzyme is bifunctional and also catalyses the activity of EC 1.2.1.103, [amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase.

History

EC 1.2.1.106 created 2021

Pathway

ec00220

Arginine biosynthesis

ec01100

Metabolic pathways

Orthology

K05829

[amino group carrier protein]-6-phospho-L-2-aminoadipate/5-phospho-L-glutamate reductase

Genes

ENF:	AKI40_3666(argC1)

CARI:

FNU76_03415(argC)

ADE:

Adeh_0171

ACP:	A2cp1_0191

AFW:	Anae109_0180

ANK:	AnaeK_0180

AORY:

AMOR_27130(argC_1)

MXA:	MXAN_5110(argC)

MSD:	MYSTI_01367 MYSTI_05599

MYM:	A176_001775

MFB:	MFUL124B02_07590 MFUL124B02_30545

MYX:	QEG98_27715(argC)

MLAN:

JY572_19525(argC) JY572_39290(argC)

CCX:	COCOR_02066(argC) COCOR_02384(argC1)

MFU:	LILAB_33480

MMAS:

MYMAC_004992

PPAK:

JY651_06055(argC) JY651_31935(argC)

SUR:	STAUR_5875(argC) STAUR_7165

AGE:	AA314_09030

AVM:	JQX13_05280(argC) JQX13_36440(argC)

MBD:	MEBOL_002073

CFUS:

CYFUS_008834

VIN:	AKJ08_2701

CCRO:

CMC5_013340(argC)

MRM:	A7982_11144

LLU:	AKJ09_08207

HOH:

Hoch_4934

PMS:	KNP414_04936

PMQ:	PM3016_4338

PMW:

B2K_22475

PIH:	UB51_14595

PSWU:

SY83_08900

GEK:	kuro4_23330(argC)

SGR:

SGR_3479

SFI:

SFUL_3351

SSX:	SACTE_1738

SFA:

Sfla_0120

STRP:

F750_6904

SCI:	B446_19850(lysY)

SLC:	SL103_03075

SPRI:

SPRI_3643

SCZ:	ABE83_19105

SCX:	AS200_22010

SRW:	TUE45_06897(argC_2)

SPAV:

Spa2297_32275

STRT:

A8713_31070

SALW:

CP975_34095(argC)

SLAU:

SLA_3044

SALJ:

SMD11_6707(lysY)

STRO:

STRMOE7_34015

STIR:

DDW44_16560(argC)

SNK:	CP967_01835(argC) CP967_15200(argC)

SFIC:

EIZ62_06085

SSPO:

DDQ41_08070(argC)

SCAV:

CVT27_15445(argC)

SCYG:

S1361_31455(argC2)

SGJ:	IAG43_00725(argC)

SDD:	D9753_06835(argC)

SINE:

KI385_33355(argC)

SAKB:

K1J60_19055(argC)

SSPN:

LXH13_29735(argC)

SOV:	QZH56_15295(argC)

SROC:

RGF97_02770(argC) RGF97_22065(argC)

SLUO:

PS467_34280(argC)

STPB:

QR97_19340

STRW:

QHG49_20980(argC)

SGLY:

P8A20_28275(argC)

KAB:	B7C62_16030

KIT:	CFP65_3941

AGRA:

AGRA3207_003395(argC)

ACIR:

OG979_26755(argC)

SESP:

BN6_56700

SSYI:

EKG83_30605

MFEU:

H1D33_25925(argC)

ASE:	ACPL_7490(argC)

ACTS:

ACWT_7360

ACTR:

Asp14428_21590(argC_1)

PLK:	CIK06_18385(argC)

DAUR:

Daura_16045(argC)

CAI:

Caci_6304

NAV:	JQS30_10085(argC)

RRS:	RoseRS_1060

RCA:

Rcas_3468

CAU:

Caur_0335

CHL:	Chy400_0360

CAG:

Cagg_3596

HAU:

Haur_3307

CALL:

OZ401_000131(argC)

ATM:	ANT_12400(argC)

PSUB:

Pelsub_P1479

LEK:	hrd7_27810(argC)

CAP:	CLDAP_41080(argC)

KBS:	EPA93_38765

KBB:	ccbrp13_35980(argC_1)

THUG:

KNN16_06515(argC)

TTR:

Tter_0319

PMET:

G4Y79_18400

TRO:	trd_1518(argC)

STI:

Sthe_0216

DRA:	DR_0963(argC)

DGE:

Dgeo_0685

DDR:	Deide_10350

DMR:	Deima_1349

DGO:	DGo_CA1602(argC)

DPD:	Deipe_2758

DSW:	QR90_11525

DCH:	SY84_01780

DAB:	AUC44_08830

DPU:	SU48_07465

DEZ:	DKM44_07625

DWU:	DVJ83_06415

DFC:

DFI_07605

DEIN:

DAAJ005_07915

DGA:	DEGR_14640(argC1)

DPH:	EHF33_04575

DRD:	LMT64_04455

DRB:	N0D28_07415(argC)

DAH:	DAETH_16370(argC1)

DAQU:

M8445_13445(argC)

DTAE:

LAJ19_05170(argC)

DMB:	E5F05_13170

DSC:	ABOD76_16800(argC)

TRA:

Trad_1395

TTH:

TT_C1542

TTJ:	TTHA1904(TTHA1904)

TTS:	Ththe16_1906

TTL:	TtJL18_1988

TSC:	TSC_c01930(argC1)

THC:	TCCBUS3UF1_21020

TOS:	Theos_1932

TAQ:

TO73_0099

TPAR:

AV541_01265

TBC:	A0O31_00869(argC_1)

TANT:

KNN15_05135(argC)

MRB:

Mrub_2723

MRE:	K649_08920(argC)

MTAI:

Mtai_v1c23220

MSV:	Mesil_0436

OPR:	Ocepr_1788

MHD:	Marky_0667

UAM:	UABAM_02297

CTM:	Cabther_B0218

CVL:	J8C06_12705(argC)

CHLO:

J8C02_13760(argC)

SCOR:

J3U87_02880

MSIL:

METEAL_32710(argC1)

MSEA:

METESE_28820(argC1)

TAI:

Taci_0448

CPOR:

BED41_13055

TLI:

Tlie_1470

AMO:	Anamo_0989

ARAM:

KAR29_00425(argC)

RMR:

Rmar_0948

RMG:	Rhom172_1918

RBAR:

AWN76_002230

MRO:

MROS_0164

CABY:

Cabys_3149(argC)

PFU:

PF1683

PFI:	PFC_10190(argC)

PHO:	PH1720(PH1720)

PAB:	PAB0291(argC)

PYN:

PNA2_0328

PYS:

Py04_1635

TKO:

TK0277

THS:

TES1_0508

THV:	ADU37_CDS10060

TCH:	CHITON_1978

THEI:

K1720_00620(argC)

HDL:	HALDL1_01650

HHB:	Hhub_3649(argC)

HNO:	LT974_00085(argC)

HLU:	LT972_14175(argC)

HALH:

HTSR_0665(argC)

HHSR:

HSR6_0691(argC)

HSU:	HLASF_2138(argC)

HSF:	HLASA_2172(argC)

HAHS:

HSRCO_2860(argC)

SALR:

FQU85_04730

HALR:

EFA46_004290

HJE:	HacjB3_00985(argC)

HDO:	MUK72_02360(argC)

HALX:

M0R89_05930(argC)

HAXZ:

M0R88_06115(argC)

HAYC:

NGM10_09015(argC)

HAXY:

NGM07_11165(argC)

SALI:

L593_07890(argC)

SAIM:

K0C01_05790(argC)

HARA:

AArcS_3062(argC)

HMA:	rrnAC2678(argC)

HHI:	HAH_3082(argC)

HHN:	HISP_15690

HAB:	SG26_07785

HTA:	BVU17_15000

HALJ:

G9465_02500

HSIN:

KDQ40_13800

NPH:	NP_5260A(argC)

NMO:	Nmlp_1242(argC)

NHO:	HWV23_08505

NSAL:

HWV07_10860

HUT:

Huta_1501

HTI:

HTIA_1540

HALA:

Hrd1104_12290

HASV:

SVXHr_0125(argC)

HABN:

HBNXHr_0122(argC)

HMU:

Hmuk_0773

HALZ:

E5139_07050

HALL:

LC1Hm_3289(argC)

HAZP:

GBQ70_07045

HALI:

BV210_07080

HSN:	DV733_03390

HDS:	HSR122_1704(argC)

HRR:	HZS55_04380

HPEL:

HZS54_04330

HLT:	I7X12_08370

HARC:

HARCEL1_01520

SSAI:

N0B31_18445(argC)

HAAD:

MW046_06600(argC)

HWA:	HQ_3715A(argC)

HWC:	Hqrw_4130(argC)

HVO:	HVO_0045(argC)

HALE:

G3A49_00605

HLN:	SVXHx_0043(argc)

HME:	HFX_0045(argC)

HGI:	ABY42_00215

HLS:	KU306_04865(argC)

HBO:	Hbor_01740

HAQ:	DU484_03080

HAJ:	DU500_03520

HAER:

DU502_01265

HRA:	EI982_12720

HLM:	DV707_00745

HALM:

FCF25_06930

HLA:

Hlac_2615

HALP:

DOS48_13130

HALB:

EKH57_10850

HEZZ:

EO776_15100

HALQ:

Hrr1229_007370

HSS:	J7656_01820

HSAI:

HPS36_07355

HAZZ:

KI388_13085(argC)

HAE:	halTADL_1874

HALN:

B4589_001580

HALG:

HUG10_12790

HALU:

HUG12_02035

HMP:	K6T50_10110(argC)

HRE:	K6T36_09875(argC)

HRM:	K6T25_06295(argC)

HACB:

Hbl1158_01730(argC)

HDF:	AArcSl_0042(argC)

HAAA:

AArcCO_0044(argC)

HAH:	Halar_1203

HTU:

Htur_0327

HSAL:

JMJ58_07540

HAKZ:

J0X25_08130(argC)

NMG:	Nmag_1760(argC)

HXA:	Halxa_1379

NAT:

NJ7G_0262

NPE:	Natpe_3685

NVR:	FEJ81_17600

NPL:	FGF80_16425

NAY:	HYG81_11425(argC)

HALY:

HYG82_14940

HJT:	DVR14_08505

HLO:	J0X27_11125

NGE:	Natgr_1613

HRU:	Halru_0400

SAWL:

NGM29_05190(argC)

HALV:

NGM15_14815(argC)

NOU:	Natoc_0149

HLR:	HALLA_05495

HLC:	CHINAEXTREME04210

NAJ:	B1756_08245

NAG:	AArcMg_3555

NAN:	AArc1_3499

NARA:

QQ977_06800(argC)

NBG:	DV706_07695

NAS:	GCU68_05000

HDA:	BB347_12545

PTO:

PTO1472

FAC:	FACI_IFERC01G1524

FAI:	FAD_0505(lysY)

CDIV:

CPM_0548

APE:	APE_1462(lysY)

ACJ:

ACAM_0921

IHO:

Igni_0728

IIS:

EYM_02375

IPC:

IPA_02535

IAG:

Igag_1754

PFM:	Pyrfu_0758

PDL:	Pyrde_1835

PABI:

PABY_17870(argC)

PARE:

PYJP_07910(argC)

STO:	STK_01950(argC_lysY)

SOH:	D1869_00450

SSO:	SSO0155(argC)

SOL:

Ssol_1133

SSOA:

SULA_1169

SSOL:

SULB_1170

SSOF:

SULC_1168

SSHI:

J5U23_00109

SCAS:

SACC_00680

SAI:	Saci_0750(argC)

SACN:

SacN8_03645(argC)

SACR:

SacRon12I_03630(argC)

SACS:

SUSAZ_03360

SIS:	LS215_2149

SIA:	M1425_1984

SIM:	M1627_2062

SID:

M164_1990

SIY:	YG5714_2107

SIN:	YN1551_0811

SII:

LD85_2245

SIH:

SiH_1928

SIR:

SiRe_1855

SIC:

SiL_1837

SULA:

BFU36_05160

SULE:

GFS03_10865

SULL:

EWF20_01890

MSE:

Msed_0164

MEMJ:

MJ1HA_0243

MCN:

Mcup_1909

MHK:	DFR87_05990

MPRU:

DFR88_05820

MTEN:

GWK48_06270

MJN:	MjAS7_0747

AHO:

Ahos_0883

AMAN:

B6F84_08265

ABRI:

DFR85_06580

ASUL:

DFR86_07280

AAMB:

D1866_12310

ACIH:

HS5_22580

SACD:

HS1genome_0844

SAZO:

D1868_01595

CSTY:

KN1_18170

STEP:

IC006_1902

SMET:

RQ359_002321(argC)

PAI:

PAE2881

PIS:

Pisl_0276

PCL:

Pcal_0373

PAS:

Pars_0966

PYR:

P186_1636

POG:

Pogu_1380

TNE:

Tneu_1837

PYW:	PYWP30_01976

CMA:

Cmaq_1301

TTN:	TTX_0120(lysY_argC)

TUZ:

TUZN_1285

VDI:

Vdis_0193

VMO:

VMUT_1533

VSO:	Vsou_14280

KCR:

Kcr_0809

NMR:

Nmar_1289

NIR:	NSED_07155(argC)

NKR:	NKOR_07275(argC)

NID:	NPIRD3C_0835(argC)

NIN:	NADRNF5_0667(argC)

NIW:	Nisw_07285

NCL:	C5F47_06945

NOX:	C5F49_06955

NUE:	C5F50_09710

NIP:	NsoK4_01590

NZT:	NZOSNM25_000522

NCT:

NMSP_0399

NIC:	DSQ20_07910

NGA:	Ngar_c29960(argC)

NVN:	NVIE_016490(argC)

NEV:

NTE_00734

TAA:	NMY3_02222(argC2)

NFN:	NFRAN_2984(lysY)

NCV:	NCAV_1251(lysY)

NDV:	NDEV_1624(argC)

CSY:	CENSYa_1203

CSU:	CSUB_C1303

NBV:	T478_1044(argC)

TAH:	SU86_009075

NIU:	DSQ19_03220

CCAI:

NAS2_0267

BARB:

AOA66_0020

» show all

Reference

1 [PMID:23434852]

Authors

Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M

Title

Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.

Journal

Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200

Sequence

[sai:Saci_0750]

Reference

2 [PMID:27566549]

Authors

Yoshida A, Tomita T, Atomi H, Kuzuyama T, Nishiyama M

Title

Lysine Biosynthesis of Thermococcus kodakarensis with the Capacity to Function as an Ornithine Biosynthetic System.