| Entry |
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| Name |
Cortisol;
Hydrocortisone;
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione;
Kendall's compound F;
Reichstein's substance M
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| Formula |
C21H30O5
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| Exact mass |
362.2093
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| Mol weight |
362.46
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| Structure |
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| Remark |
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| Reaction |
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| Pathway |
| map04080 | Neuroactive ligand-receptor interaction |
| map04927 | Cortisol synthesis and secretion |
| map04960 | Aldosterone-regulated sodium reabsorption |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Module |
| M00109 | C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone |
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| Network |
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| Enzyme |
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| Brite |
Compounds with biological roles [BR:br08001]
Steroids
21-Carbon atoms
Pregnane derivatives
C00735 Cortisol
Hormones and transmitters
Steroid hormones
Glucocorticoids
C00735 Cortisol
Lipids [BR:br08002]
ST Sterol lipids
ST02 Steroids
ST0203 C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives
C00735 Cortisol
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC03 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA02 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA01 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA02 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XA Corticosteroids, weak, other combinations
D07XA01 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB09 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA02 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB03 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA01 Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, Low Potency
Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN)
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN)
Inflammatory Bowel Disease Agents
Glucocorticoids
Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
245 Adrenal hormone preparations
2452 Cortisones
D00088 Hydrocortisone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00088 Hydrocortisone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN)
Second-class OTC drugs
Inorganic and organic chemicals
Hydrocortisone
D00088 Hydrocortisone (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
D00088 Hydrocortisone
Dermatological agent
DG03243 Atopic dermatitis agent
D00088 Hydrocortisone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
D00088 Hydrocortisone
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00088 Hydrocortisone
Dermatological agent
DG03243 Atopic dermatitis agent
D00088 Hydrocortisone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00088 Hydrocortisone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00088 Hydrocortisone
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00088
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00088
Topical steroids potency [br08317.html]
Classification in the USA
D00088
Rx-to-OTC switch list in the USA [br08315.html]
D00088
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 26
1 C1y C 25.3915 -16.8055
2 C1y C 24.2081 -17.4875
3 C1z C 25.3915 -15.4414
4 C1x C 27.7583 -16.8055
5 C1y C 23.0247 -16.8055
6 C1x C 24.1965 -18.8575
7 C1z C 26.5809 -14.7535
8 C1x C 24.2081 -14.7535
9 C1a C 25.3858 -14.0713
10 C1x C 27.7583 -15.4414
11 C1z C 21.8356 -17.4875
12 C1y C 23.0247 -15.4414
13 C1x C 23.0247 -19.5395
14 C5a C 26.5866 -13.3893
15 C2y C 21.8356 -18.8575
16 C1x C 20.6579 -16.8055
17 C1a C 21.8239 -16.1233
18 O1a O 21.8356 -14.7535
19 C1b C 27.7643 -12.7072
20 O5a O 25.3975 -12.7072
21 C2x C 20.6579 -19.5395
22 C1x C 19.4687 -17.4875
23 O1a O 28.9534 -13.3951
24 C5x C 19.4687 -18.8575
25 O5x O 18.2853 -19.5395
26 O1a O 27.9332 -14.3911
BOND 29
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 3 9 1 #Up
9 4 10 1
10 5 11 1
11 5 12 1
12 6 13 1
13 7 14 1 #Up
14 11 15 1
15 11 16 1
16 11 17 1 #Up
17 12 18 1 #Up
18 14 19 1
19 14 20 2
20 15 21 2
21 16 22 1
22 19 23 1
23 21 24 1
24 24 25 2
25 7 10 1
26 8 12 1
27 13 15 1
28 22 24 1
29 7 26 1 #Down
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