Entry
Name
Lactosylceramide;
LacCer;
CD17
Composition
(Gal)1 (Glc)1 (Cer)1
Mass
324.3 (Cer)
Structure
KCF file KCaM SNFG
Remark
Reaction
Pathway
map00601 Glycosphingolipid biosynthesis - lacto and neolacto series
map00603 Glycosphingolipid biosynthesis - globo and isoglobo series
map00604 Glycosphingolipid biosynthesis - ganglio series
Module
M00068 Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer
M00069 Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3
M00070 Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer
M00071 Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer
Network
nt06014 Sphingolipid degradation
nt06035 Blood group carbohydrate antigen biosynthesis
Enzyme
Brite
Compounds with biological roles [BR:br08001 ]
Lipids
Glycolipids
Glycosphingolipids
C01290 Lactosylceramide
CD molecules [BR:ko04090 ]
Carbohydrates
G00092 CD17; CD17, lactosylceramide, LacCer
Lipids [BR:br08002 ]
SP Sphingolipids
SP05 Neutral glycosphingolipids
SP0501 Simple Glc series
G00092 Gal-beta1->4Glc-beta1->1'Cer (LacCer)
BRITE hierarchy
Reference
Authors
Larson G, Falk P, Hoskins LC.
Title
Degradation of human intestinal glycosphingolipids by extracellular glycosidases from mucin-degrading bacteria of the human fecal flora.
Journal
J Biol Chem 263:10790-8 (1988)
Reference
Authors
Wu AM.
Title
Carbohydrate structural units in glycoproteins and polysaccharides as important ligands for Gal and GalNAc reactive lectins.
Journal
Reference
Authors
Holmes EH, Hakomori S, Ostrander GK.
Title
Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.
Journal
J Biol Chem 262:15649-58 (1987)
Reference
Authors
Ideo H, Seko A, Yamashita K.
Title
Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells.
Journal
Other DBs
LinkDB
All DBs
KCF data
Show NODE 3
1 Cer 9 0
2 Glc 0 0
3 Gal -9 0
EDGE 2
1 2:b1 1:1
2 3:b1 2:4