Homo sapiens (human): 7186
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Entry
7186 CDS
T01001
Symbol
TRAF2, MGC:45012, RNF117, TRAP, TRAP3
Name
(RefSeq) TNF receptor associated factor 2
KO
K03173
TNF receptor-associated factor 2 [EC:
2.3.2.27
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04137
Mitophagy - animal
hsa04141
Protein processing in endoplasmic reticulum
hsa04210
Apoptosis
hsa04217
Necroptosis
hsa04380
Osteoclast differentiation
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04657
IL-17 signaling pathway
hsa04668
TNF signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04932
Non-alcoholic fatty liver disease
hsa05010
Alzheimer disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05017
Spinocerebellar ataxia
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05135
Yersinia infection
hsa05160
Hepatitis C
hsa05163
Human cytomegalovirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05203
Viral carcinogenesis
hsa05222
Small cell lung cancer
hsa05417
Lipid and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06223
TNF signaling (cancer)
nt06231
Apoptosis (cancer)
nt06263
Hepatocellular carcinoma
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06466
Pathways of neurodegeneration
nt06516
TNF signaling
nt06517
TLR signaling
nt06524
Apoptosis
nt06527
Necroptosis
nt06534
Unfolded protein response
Element
N00145
Extrinsic apoptotic pathway
N00151
TNF-NFKB signaling pathway
N00173
KSHV K15 to TNF-NFKB signaling pathway
N00174
KSHV vFLIP to TNF-NFKB signaling pathway
N00441
HIV gp120 to TNF-NFKB signaling pathway
N00442
HIV Nef to TNF-NFKB signaling pathway
N00444
TNF-p38 signaling pathway
N00446
TNF-JNK signaling pathway
N00505
CD40-NFKB signaling pathway
N00525
HCV NS5A to TNF-NFKB signaling pathway
N00559
LIGHT-HVEM-NFKB signaling pathway
N00560
HSV gD to HVEM-NFKB signaling pathway
N00859
Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00928
Escherichia NleB to TNF-NFKB signaling pathway
N00944
Shigella OspI to TNF-NFKB signaling pathway
N01013
IRE1a-JNK signaling pathway
N01113
Salmonella SseK1 to TNF-NFKB signaling pathway
N01621
TNF-RIPK1/3 signaling pathway
N01796
TNFSF4-TNFRSF4 signaling pathway
N01798
TNFSF11-TNFRSF11A signaling pathway
N01799
CD70-CD27 signaling pathway
N01801
TNFSF13-TNFRSF13B/C signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
7186 (TRAF2)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
7186 (TRAF2)
04064 NF-kappa B signaling pathway
7186 (TRAF2)
04668 TNF signaling pathway
7186 (TRAF2)
04071 Sphingolipid signaling pathway
7186 (TRAF2)
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
7186 (TRAF2)
09143 Cell growth and death
04210 Apoptosis
7186 (TRAF2)
04217 Necroptosis
7186 (TRAF2)
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
7186 (TRAF2)
04622 RIG-I-like receptor signaling pathway
7186 (TRAF2)
04657 IL-17 signaling pathway
7186 (TRAF2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
7186 (TRAF2)
09158 Development and regeneration
04380 Osteoclast differentiation
7186 (TRAF2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
7186 (TRAF2)
05203 Viral carcinogenesis
7186 (TRAF2)
09162 Cancer: specific types
05222 Small cell lung cancer
7186 (TRAF2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
7186 (TRAF2)
05160 Hepatitis C
7186 (TRAF2)
05168 Herpes simplex virus 1 infection
7186 (TRAF2)
05163 Human cytomegalovirus infection
7186 (TRAF2)
05167 Kaposi sarcoma-associated herpesvirus infection
7186 (TRAF2)
05169 Epstein-Barr virus infection
7186 (TRAF2)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
7186 (TRAF2)
05132 Salmonella infection
7186 (TRAF2)
05131 Shigellosis
7186 (TRAF2)
05135 Yersinia infection
7186 (TRAF2)
09164 Neurodegenerative disease
05010 Alzheimer disease
7186 (TRAF2)
05014 Amyotrophic lateral sclerosis
7186 (TRAF2)
05016 Huntington disease
7186 (TRAF2)
05017 Spinocerebellar ataxia
7186 (TRAF2)
05022 Pathways of neurodegeneration - multiple diseases
7186 (TRAF2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
7186 (TRAF2)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
7186 (TRAF2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:
hsa03019
]
7186 (TRAF2)
04121 Ubiquitin system [BR:
hsa04121
]
7186 (TRAF2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.27 RING-type E3 ubiquitin transferase
7186 (TRAF2)
Messenger RNA biogenesis [BR:
hsa03019
]
Eukaryotic type
mRNA surveillance and transport factors
mRNA cycle factors
Stress granule specific factors
7186 (TRAF2)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Single Ring-finger type E3
TRAF proteins
7186 (TRAF2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
TRAF-mep_MATH
MATH_2
TRAF_BIRC3_bd
zf-TRAF
TRAF2_zf
zf-C3HC4
TRAF3_RING
zf-C3HC4_2
zf-RING_6
MATH
SlyX
Motif
Other DBs
NCBI-GeneID:
7186
NCBI-ProteinID:
NP_066961
OMIM:
601895
HGNC:
12032
Ensembl:
ENSG00000127191
UniProt:
Q12933
Structure
PDB
PDBj
LinkDB
All DBs
Position
9:136881958..136926607
Genome browser
AA seq
501 aa
AA seq
DB search
MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLAS
ILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKE
YESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE
VCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWL
REHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTA
EACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISD
FARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDA
LLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEA
KNSYVRDDAIFIKAIVDLTGL
NT seq
1506 nt
NT seq
+upstream
nt +downstream
nt
atggctgcagctagcgtgaccccccctggctccctggagttgctacagcccggcttctcc
aagaccctcctggggaccaagctggaagccaagtacctgtgctccgcctgcagaaacgtc
ctccgcaggcccttccaggcgcagtgtggccaccggtactgctccttctgcctggccagc
atcctcagctctgggcctcagaactgtgctgcctgtgttcacgagggcatatatgaagaa
ggcatttctattttagaaagcagttcggccttcccagataatgctgcccgcagggaggtg
gagagcctgccggccgtctgtcccagtgatggatgcacctggaaggggaccctgaaagaa
tacgagagctgccacgaaggccgctgcccgctcatgctgaccgaatgtcccgcgtgcaaa
ggcctggtccgccttggtgaaaaggagcgccacctggagcacgagtgcccggagagaagc
ctgagctgccggcattgccgggcaccctgctgcggagcagacgtgaaggcgcaccacgag
gtctgccccaagttccccttaacttgtgacggctgcggcaagaagaagatcccccgggag
aagtttcaggaccacgtcaagacttgtggcaagtgtcgagtcccttgcagattccacgcc
atcggctgcctcgagacggtagagggtgagaaacagcaggagcacgaggtgcagtggctg
cgggagcacctggccatgctactgagctcggtgctggaggcaaagcccctcttgggagac
cagagccacgcggggtcagagctcctgcagaggtgcgagagcctggagaagaagacggcc
acttttgagaacattgtctgcgtcctgaaccgggaggtggagagggtggccatgactgcc
gaggcctgcagccggcagcaccggctggaccaagacaagattgaagccctgagtagcaag
gtgcagcagctggagaggagcattggcctcaaggacctggcgatggctgacttggagcag
aaggtcttggagatggaggcatccacctacgatggggtcttcatctggaagatctcagac
ttcgccaggaagcgccaggaagctgtggctggccgcatacccgccatcttctccccagcc
ttctacaccagcaggtacggctacaagatgtgtctgcgtatctacctgaacggcgacggc
accgggcgaggaacacacctgtccctcttctttgtggtgatgaagggcccgaatgacgcc
ctgctgcggtggcccttcaaccagaaggtgaccttaatgctgctcgaccagaataaccgg
gagcacgtgattgacgccttcaggcccgacgtgacttcatcctcttttcagaggccagtc
aacgacatgaacatcgcaagcggctgccccctcttctgccccgtctccaagatggaggca
aagaattcctacgtgcgggacgatgccatcttcatcaaggccattgtggacctgacaggg
ctctaa
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