KEGG   PATHWAY: ko00330
Entry
ko00330                     Pathway                                
Name
Arginine and proline metabolism
Class
Metabolism; Amino acid metabolism
Pathway map
ko00330  Arginine and proline metabolism
ko00330

Module
M00015  Proline biosynthesis, glutamate => proline [PATH:ko00330]
M00047  Creatine pathway [PATH:ko00330]
M00133  Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:ko00330]
M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:ko00330]
M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:ko00330]
M00136  GABA biosynthesis, prokaryotes, putrescine => GABA [PATH:ko00330]
M00879  Arginine succinyltransferase pathway, arginine => glutamate [PATH:ko00330]
M00970  Proline degradation, proline => glutamate [PATH:ko00330]
M00972  Proline metabolism [PATH:ko00330]
Other DBs
GO: 0006525 0006560
Orthology
K00613  glycine amidinotransferase [EC:2.1.4.1]
K00542  guanidinoacetate N-methyltransferase [EC:2.1.1.2]
K00933  creatine kinase [EC:2.7.3.2]
K27382  creatine kinase M-type [EC:2.7.3.2]
K01470  creatinine amidohydrolase [EC:3.5.2.10]
K01485  cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21]
K03365  cytosine/creatinine deaminase [EC:3.5.4.1 3.5.4.21]
K01473  N-methylhydantoinase A [EC:3.5.2.14]
K01474  N-methylhydantoinase B [EC:3.5.2.14]
K08687  N-carbamoylsarcosine amidase [EC:3.5.1.59]
K08688  creatinase [EC:3.5.3.3]
K01583  arginine decarboxylase [EC:4.1.1.19]
K01584  arginine decarboxylase [EC:4.1.1.19]
K01585  arginine decarboxylase [EC:4.1.1.19]
K02626  arginine decarboxylase [EC:4.1.1.19]
K01480  agmatinase [EC:3.5.3.11]
K10536  agmatine deiminase [EC:3.5.3.12]
K12251  N-carbamoylputrescine amidase [EC:3.5.1.53]
K14329  agmatine coumaroyltransferase [EC:2.3.1.64 2.3.1.-]
K27502  carboxyaminopropylagmatine dehydrogenase [EC:1.5.1.55]
K27684  carboxyaminopropylagmatine decarboxylase [EC:4.1.1.127]
K27683  N1-aminopropylagmatine ureohydrolase [EC:3.5.3.24]
K01581  ornithine decarboxylase [EC:4.1.1.17]
K00797  spermidine synthase [EC:2.5.1.16]
K24034  spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming) [EC:2.5.1.16 1.5.1.10]
K00802  spermine synthase [EC:2.5.1.22]
K01611  S-adenosylmethionine decarboxylase [EC:4.1.1.50]
K13746  carboxynorspermidine synthase [EC:1.5.1.43]
K13747  carboxynorspermidine decarboxylase [EC:4.1.1.96]
K11182  diamine oxidase [EC:1.4.3.22]
K09251  putrescine aminotransferase [EC:2.6.1.82]
K12256  putrescine---pyruvate transaminase [EC:2.6.1.113]
K03343  putrescine oxidase [EC:1.4.3.10]
K12259  spermine oxidase [EC:1.5.3.16 1.5.3.-]
K13366  polyamine oxidase [EC:1.5.3.14 1.5.3.16 1.5.3.-]
K17839  polyamine oxidase [EC:1.5.3.17 1.5.3.-]
K13367  polyamine oxidase [EC:1.5.3.17]
K00316  spermidine dehydrogenase [EC:1.5.99.6]
K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K00149  aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
K00137  aminobutyraldehyde dehydrogenase [EC:1.2.1.19]
K12254  4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase [EC:1.2.1.54 1.2.1.-]
K05604  beta-Ala-His dipeptidase [EC:3.4.13.20]
K08660  cytosolic nonspecific dipeptidase [EC:3.4.13.18]
K14755  carnosine synthase [EC:6.3.2.11]
K00657  diamine N-acetyltransferase [EC:2.3.1.57]
K00274  monoamine oxidase [EC:1.4.3.4]
K12252  arginine:pyruvate transaminase [EC:2.6.1.84]
K21639  L-arginine oxidase [EC:1.4.3.25]
K12253  5-guanidino-2-oxopentanoate decarboxylase [EC:4.1.1.75]
K12255  guanidinobutyrase [EC:3.5.3.7]
K25365  guanidinobutyrase / D-arginase [EC:3.5.3.7 3.5.3.10]
K27001  taurocyamine/4-guanidinobutanoate/3-guanidinopropanoate hydrolase [EC:3.5.3.- 3.5.3.7 3.5.3.17]
K01426  amidase [EC:3.5.1.4]
K00673  arginine N-succinyltransferase [EC:2.3.1.109]
K01484  succinylarginine dihydrolase [EC:3.5.3.23]
K00840  succinylornithine aminotransferase [EC:2.6.1.81]
K06447  succinylglutamic semialdehyde dehydrogenase [EC:1.2.1.71]
K05526  succinylglutamate desuccinylase [EC:3.5.1.96]
K09470  gamma-glutamylputrescine synthase [EC:6.3.1.11]
K09471  gamma-glutamylputrescine oxidase [EC:1.4.3.-]
K09472  4-(gamma-glutamylamino)butanal dehydrogenase [EC:1.2.1.99]
K09473  gamma-glutamyl-gamma-aminobutyrate hydrolase [EC:3.5.1.94]
K23233  D-octopine dehydrogenase [EC:1.5.1.11]
K00296  D-nopaline dehydrogenase [EC:1.5.1.19]
K24952  nopaline oxidase subunit A
K24953  nopaline oxidase subunit B
K24954  octopine oxidase subunit A
K24955  octopine oxidase subunit B
K00934  arginine kinase [EC:2.7.3.3]
K13240  nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
K13242  nitric-oxide synthase, endothelial [EC:1.14.13.39]
K13427  nitric-oxide synthase, plant [EC:1.14.13.39]
K00491  nitric-oxide synthase, bacterial [EC:1.14.14.47]
K27542  arginine dihydrolase [EC:3.5.3.27]
K27545  arginine dihydrolase [EC:3.5.3.27]
K01476  arginase [EC:3.5.3.1]
K00819  ornithine--oxo-acid transaminase [EC:2.6.1.13]
K00286  pyrroline-5-carboxylate reductase [EC:1.5.1.2]
K00318  proline dehydrogenase [EC:1.5.5.2]
K13821  RHH-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]
K01750  ornithine cyclodeaminase [EC:4.3.1.12]
K00294  1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]
K00931  glutamate 5-kinase [EC:2.7.2.11]
K00147  glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]
K12657  delta-1-pyrroline-5-carboxylate synthetase [EC:2.7.2.11 1.2.1.41]
K22842  L-glutamate-5-semialdehyde N-acetyltransferase [EC:2.3.1.271]
K01259  proline iminopeptidase [EC:3.4.11.5]
K11142  cytosol aminopeptidase [EC:3.4.11.1 3.4.11.5]
K00472  prolyl 4-hydroxylase [EC:1.14.11.2]
K23121  trans-4-hydroxy-L-proline dehydratase [EC:4.2.1.172]
K11394  hydroxyproline dehydrogenase [EC:1.5.5.3]
K14454  aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455  aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K00811  aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812  aspartate aminotransferase [EC:2.6.1.1]
K00813  aspartate aminotransferase [EC:2.6.1.1]
K11358  aspartate aminotransferase [EC:2.6.1.1]
K00824  D-alanine transaminase [EC:2.6.1.21]
K18123  4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16]
K01777  proline racemase [EC:5.1.1.4]
K21672  2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
K10793  D-proline reductase (dithiol) PrdA [EC:1.21.4.1]
K10794  D-proline reductase (dithiol) PrdB [EC:1.21.4.1]
K00273  D-amino-acid oxidase [EC:1.4.3.3]
K17851  D-proline dehydrogenase [EC:1.5.99.13]
K18384  trans-L-3-hydroxyproline dehydratase [EC:4.2.1.77]
K22548  trans-L-3-hydroxyproline dehydratase [EC:4.2.1.77]
K21624  cis-L-3-hydroxyproline dehydratase [EC:4.2.1.171]
K09123  cis-L-3-hydroxyproline dehydratase [EC:4.2.1.171]
K19743  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]
K19742  1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
ko00020  Citrate cycle (TCA cycle)
ko00220  Arginine biosynthesis
ko00250  Alanine, aspartate and glutamate metabolism
ko00260  Glycine, serine and threonine metabolism
ko00270  Cysteine and methionine metabolism
ko00310  Lysine degradation
ko00410  beta-Alanine metabolism
ko00470  D-Amino acid metabolism
ko00480  Glutathione metabolism
ko00630  Glyoxylate and dicarboxylate metabolism
ko00650  Butanoate metabolism
ko00770  Pantothenate and CoA biosynthesis
ko00960  Tropane, piperidine and pyridine alkaloid biosynthesis
LinkDB

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