KEGG   PATHWAY: amil04142
Entry
amil04142                   Pathway                                
Name
Lysosome - Acropora millepora
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
amil04142  Lysosome
amil04142

Other DBs
GO: 0005764
Organism
Acropora millepora [GN:amil]
Gene
114960650  V-type proton ATPase 116 kDa subunit a-like isoform X1 [KO:K02154]
114968902  V-type proton ATPase subunit d 1-like [KO:K02146]
114961202  V-type proton ATPase subunit H-like [KO:K02144]
114971966  V-type proton ATPase subunit S1-like [KO:K03662]
114946823  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
114961356  V-type proton ATPase 21 kDa proteolipid subunit-like [KO:K03661]
114953874  dmX-like protein 2 [KO:K24155]
114955851  LOW QUALITY PROTEIN: WD repeat-containing protein 7-like [KO:K24738]
114967724  cathepsin B-like protease 2 [KO:K01363] [EC:3.4.22.1]
114970027  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
114955731  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
114958508  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
114975877  cathepsin L-like [KO:K01373] [EC:3.4.22.41]
114957723  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114957757  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
114957778  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114957124  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114957125  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114957126  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114964037  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114964992  cathepsin O-like [KO:K01374] [EC:3.4.22.42]
114964139  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
114962334  legumain-like [KO:K01369] [EC:3.4.22.34]
114968861  tripeptidyl-peptidase 1-like [KO:K01279] [EC:3.4.14.9]
114964755  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
114958834  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
114955046  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
114958680  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
114958713  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
114968339  alpha-N-acetylgalactosaminidase-like isoform X1 [KO:K01204] [EC:3.2.1.49]
114968344  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
114957734  alpha-N-acetylglucosaminidase-like [KO:K01205] [EC:3.2.1.50]
114960124  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
114952731  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
114952732  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
114967176  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
114958261  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
114958292  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
114958293  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
114968023  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
114957682  uncharacterized protein LOC114957682 [KO:K01206] [EC:3.2.1.51]
114951731  putative alpha-L-fucosidase 1 [KO:K01206] [EC:3.2.1.51]
114954642  alpha-L-fucosidase 1-like [KO:K01206] [EC:3.2.1.51]
114954478  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
114970113  uncharacterized protein LOC114970113 [KO:K12373] [EC:3.2.1.52]
114970115  uncharacterized protein LOC114970115 [KO:K12373] [EC:3.2.1.52]
114953752  beta-hexosaminidase 1-like isoform X1 [KO:K12373] [EC:3.2.1.52]
114954507  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
114946993  uncharacterized protein LOC114946993 isoform X1 [KO:K12373] [EC:3.2.1.52]
114946994  uncharacterized protein LOC114946994 [KO:K12373] [EC:3.2.1.52]
114976061  beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]
114957267  lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]
114959196  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
114975971  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
114963012  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
114970384  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
114958897  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
114962210  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
114958932  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
114952768  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
114952775  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
114952793  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
114966486  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
114954146  N-acetylgalactosamine-6-sulfatase-like isoform X1 [KO:K01132] [EC:3.1.6.4]
114968864  N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]
114970454  iduronate 2-sulfatase-like [KO:K01136] [EC:3.1.6.13]
114964843  LOW QUALITY PROTEIN: N-sulphoglucosamine sulphohydrolase-like [KO:K01565] [EC:3.10.1.1]
114961783  lipase member K-like isoform X1 [KO:K01052] [EC:3.1.1.13]
114957367  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
114962968  lipase member K-like [KO:K01052] [EC:3.1.1.13]
114962969  lipase member K-like [KO:K01052] [EC:3.1.1.13]
114976564  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
114966307  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
114966350  LOW QUALITY PROTEIN: lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
114957366  lipase member K-like [KO:K01052] [EC:3.1.1.13]
114968590  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
114968619  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
114959083  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
114961440  tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]
114946845  tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]
114946846  tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]
114976261  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
114955375  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
114967074  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like isoform X1 [KO:K01444] [EC:3.5.1.26]
114953900  uncharacterized protein LOC114953900 isoform X1 [KO:K01444] [EC:3.5.1.26]
114957382  prosaposin-like [KO:K12382]
114957445  prosaposin-like [KO:K12382]
114950903  ganglioside GM2 activator-like [KO:K12383]
114960551  palmitoyl-protein thioesterase 1-like [KO:K01074] [EC:3.1.2.22]
114965668  lysosomal thioesterase PPT2-A-like [KO:K01074] [EC:3.1.2.22]
114953175  lysosome-associated membrane glycoprotein 1-like isoform X1 [KO:K06528]
114953203  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
114973077  CD63 antigen-like [KO:K06497]
114966089  lysosome membrane protein 2-like [KO:K12384]
114966104  lysosome membrane protein 2-like isoform X1 [KO:K12384]
114973776  lysosome membrane protein 2-like [KO:K12384]
114952763  lysosome membrane protein 2-like [KO:K12384]
114969781  NPC intracellular cholesterol transporter 1-like isoform X1 [KO:K12385]
114956030  NPC intracellular cholesterol transporter 1-like [KO:K12385]
114953024  NPC intracellular cholesterol transporter 2-like [KO:K13443]
114957846  NPC intracellular cholesterol transporter 2-like [KO:K13443]
114946864  NPC intracellular cholesterol transporter 2-like [KO:K13443]
114957787  NPC intracellular cholesterol transporter 2-like [KO:K13443]
114957808  NPC intracellular cholesterol transporter 2-like isoform X1 [KO:K13443]
114957809  NPC intracellular cholesterol transporter 2-like [KO:K13443]
114952840  cystinosin-like [KO:K12386]
114965308  cystinosin homolog [KO:K12386]
114965309  cystinosin homolog [KO:K12386]
114970319  sialin-like [KO:K12301]
114955276  natural resistance-associated macrophage protein 2-like isoform X1 [KO:K21398]
114976274  lysosomal-associated transmembrane protein 4A-like [KO:K12387]
114964832  ATP-binding cassette sub-family A member 2-like [KO:K05642]
114955461  ATP-binding cassette sub-family B member 9-like [KO:K05656]
114961104  ectonucleoside triphosphate diphosphohydrolase 4-like [KO:K12305] [EC:3.6.1.6]
114970711  sortilin-like [KO:K12388]
114958053  protein BTN1-like [KO:K12389]
114970882  protein btn1-like [KO:K12389]
114973512  battenin-like [KO:K12389]
114970955  protein BTN1-like [KO:K12389]
114965401  protein BTN1-like [KO:K12389]
114968940  battenin-like [KO:K12389]
114968941  protein BTN1-like [KO:K12389]
114968946  battenin-like [KO:K12389]
114968948  protein BTN1-like isoform X1 [KO:K12389]
114968949  protein BTN1-like isoform X1 [KO:K12389]
114968956  battenin-like isoform X1 [KO:K12389]
114968960  uncharacterized protein LOC114968960 [KO:K12389]
114957079  battenin-like [KO:K12389]
114959744  protein BTN1-like [KO:K12389]
114965405  protein BTN1-like [KO:K12389]
114959812  battenin-like isoform X1 [KO:K12389]
114962388  protein BTN1-like [KO:K12389]
114964785  protein btn-1-like [KO:K12389]
114962490  protein BTN1-like [KO:K12389]
114964784  protein BTN1-like [KO:K12389]
114964786  protein BTN1-like [KO:K12389]
114965460  uncharacterized protein LOC114965460 [KO:K12307]
114975378  uncharacterized protein LOC114975378 [KO:K12307]
114947496  major facilitator superfamily domain-containing protein 8-like [KO:K12307]
114946788  heparan-alpha-glucosaminide N-acetyltransferase-like [KO:K10532] [EC:2.3.1.78]
114946814  heparan-alpha-glucosaminide N-acetyltransferase-like isoform X1 [KO:K10532] [EC:2.3.1.78]
114955678  formylglycine-generating enzyme-like [KO:K13444] [EC:1.8.3.7]
114953565  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta-like [KO:K08239] [EC:2.7.8.17]
114969545  N-acetylglucosamine-1-phosphotransferase subunit gamma-like isoform X1 [KO:K10087]
114955467  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase-like [KO:K01125] [EC:3.1.4.45]
114948446  LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor-like [KO:K06564]
114967498  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
114967499  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
114964312  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
114964320  uncharacterized protein LOC114964320 [KO:K10089]
114964745  uncharacterized protein LOC114964745 isoform X1 [KO:K10089]
114964746  uncharacterized protein LOC114964746 [KO:K10089]
114949996  clathrin light chain A-like [KO:K04644]
114968988  clathrin heavy chain 1-like [KO:K04646]
114963966  AP-1 complex subunit gamma-1-like [KO:K12391]
114948169  AP-1 complex subunit beta-1-like [KO:K12392]
114956545  AP-1 complex subunit mu-1-like [KO:K12393]
114954175  AP-1 complex subunit sigma-2-like isoform X1 [KO:K12394]
114964880  AP-3 complex subunit delta-1-like isoform X1 [KO:K12396]
114962416  AP-3 complex subunit beta-1-like [KO:K12397]
114950960  AP-3 complex subunit mu-1-like [KO:K12398]
114961756  AP-3 complex subunit sigma-1-like [KO:K12399]
114955880  AP-4 complex subunit epsilon-like isoform X1 [KO:K12400]
114968206  LOW QUALITY PROTEIN: AP-4 complex subunit beta-1-like [KO:K12401]
114970246  AP-4 complex subunit mu-like [KO:K12402]
114957843  AP-4 complex subunit sigma-like [KO:K12403]
114964715  ADP-ribosylation factor-binding protein GGA2-like [KO:K12404]
114960367  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
114970268  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
114952738  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
amil00511  Other glycan degradation
amil00531  Glycosaminoglycan degradation
amil04130  SNARE interactions in vesicular transport
amil04140  Autophagy - animal
amil04144  Endocytosis
KO pathway
ko04142   
LinkDB

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