DNA polymerase alpha 1, catalytic subunit (Q19596944)

Ribonuclease H-like superfamily

1 reference

DNA-directed DNA polymerase, family B

1 reference

DNA polymerase, palm domain superfamily

1 reference

DNA polymerase alpha, zinc finger domain superfamily

1 reference

DNA-directed DNA polymerase, family B, exonuclease domain, protein family

1 reference

Zinc finger, DNA-directed DNA polymerase, family B, alpha, protein family

1 reference

DNA polymerase alpha catalytic subunit, N-terminal domain, protein family

1 reference

DNA-directed DNA polymerase, family B, multifunctional domain, protein family

1 reference

DNA-directed DNA polymerase, family B, conserved site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

4 iron, 4 sulfur cluster binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

nucleotidyltransferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

nucleoside binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

iron-sulfur cluster binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

chromatin binding

1 reference

8 April 2019

Distinctive activities of DNA polymerases during human DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

protein binding

11 references

9 May 2019

Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Phosphorylated retinoblastoma protein stimulates DNA polymerase alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Direct interaction between cohesin complex and DNA replication machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Identification of domains of the HPV11 E1 protein required for DNA replication in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Interaction of herpes simplex virus 1 origin-binding protein with DNA polymerase alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Initiation of simian virus 40 DNA replication requires the interaction of a specific domain of human DNA polymerase alpha with large T antigen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

nucleic acid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

protein kinase binding

1 reference

9 May 2019

Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

DNA-directed DNA polymerase activity

Inhibition of DNA replication and DNA polymerase alpha activity by monoclonal anti-(DNA polymerase alpha) immunoglobulin G and F(ab) fragments

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

8 April 2019

8 April 2019

DNA polymerase-alpha. Purification and structural characterization of the near homogeneous enzyme from human KB cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

8 April 2019

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

DNA binding

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

9 May 2019

Distinctive activities of DNA polymerases during human DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

DNA replication origin binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

purine nucleotide binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

protein heterodimerization activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

single-stranded DNA binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

DNA-directed DNA polymerase activity

Inhibition of DNA replication and DNA polymerase alpha activity by monoclonal anti-(DNA polymerase alpha) immunoglobulin G and F(ab) fragments

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

9 May 2019

DNA polymerase-alpha. Purification and structural characterization of the near homogeneous enzyme from human KB cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

pyrimidine nucleotide binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

cell component

nuclear envelope

1 reference

9 May 2019

Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

nuclear matrix

1 reference

9 May 2019

On the association of DNA polymerase alpha activity with the nuclear matrix in HeLa cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

nucleolus

1 reference

9 May 2019

Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

chromatin

1 reference

9 May 2019

Ultrastructural aspects of the DNA polymerase alpha distribution during the cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

3 references

9 May 2019

9 May 2019

Intracellular localization of human DNA polymerase alpha with monoclonal antibodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

3 references

9 May 2019

9 May 2019

Distinctive activities of DNA polymerases during human DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Inhibition of DNA replication and DNA polymerase alpha activity by monoclonal anti-(DNA polymerase alpha) immunoglobulin G and F(ab) fragments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

alpha DNA polymerase:primase complex

alpha DNA polymerase:primase complex

Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

DNA synthesis involved in DNA repair

biological process

1 reference

9 May 2019

The role of DNA polymerase activity in human non-homologous end joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

lagging strand elongation

regulation of transcription involved in G1/S transition of mitotic cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

DNA replication

Distinctive activities of DNA polymerases during human DNA replication

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Inhibition of DNA replication and DNA polymerase alpha activity by monoclonal anti-(DNA polymerase alpha) immunoglobulin G and F(ab) fragments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Monoclonal antibodies against human DNA polymerase-alpha inhibit DNA replication in permeabilized human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

leading strand elongation

cell population proliferation

1 reference

9 May 2019

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

double-strand break repair via nonhomologous end joining

1 reference

9 May 2019

The role of DNA polymerase activity in human non-homologous end joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

DNA strand elongation involved in DNA replication

1 reference

9 May 2019

Inhibition of DNA replication and DNA polymerase alpha activity by monoclonal anti-(DNA polymerase alpha) immunoglobulin G and F(ab) fragments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

DNA replication, synthesis of RNA primer

1 reference

9 May 2019

Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

telomere maintenance via semi-conservative replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

G1/S transition of mitotic cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

1 reference

9 May 2019

nucleotide-excision repair

1 reference

9 May 2019

A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

DNA synthesis involved in UV-damage excision repair

1 reference

9 May 2019

The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

DNA replication initiation

1 reference

1 January 2018

Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09884&geneProductId=UniProtKB:P09884

leading strand elongation

Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

lagging strand elongation

Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

double-strand break repair via nonhomologous end joining

mitotic DNA replication initiation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

synthesis of RNA primer involved in mitotic DNA replication

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884

physically interacts with

Viroporin 3a

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

BioGRID

cytarabine

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL803

fludarabine phosphate

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1096882

gemcitabine hydrochloride

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1637

has part(s)

DNA polymerase alpha catalytic subunit, N-terminal domain

1 reference

DNA-directed DNA polymerase, family B, exonuclease domain

1 reference

Zinc finger, DNA-directed DNA polymerase, family B, alpha

1 reference

DNA-directed DNA polymerase, family B, conserved site

1 reference

DNA-directed DNA polymerase, family B, multifunctional domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

7 March 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

29 June 2016

1 reference

29 June 2016

1 reference

29 June 2016

1 reference

29 June 2016

1 reference

29 June 2016

1 reference

29 June 2016

1 reference

29 June 2016

1 reference

29 June 2016