UHRF1 plays a role in maintaining DNA methylation in mammalian cells (Q24336152)

hemi-methylated DNA-binding

GOA release 2020-03-11

1 reference

Ubiquitin-like, containing PHD and RING finger domains, 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Magnolia Bostick

1

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Jong Kyong Kim

2

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Pierre-Olivier Estève

3

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Amander Clark

4

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Sriharsa Pradhan

5

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Steven E Jacobsen

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

6

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language of work or name

English

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publication date

21 September 2007

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published in

Science

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volume

317

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issue

5845

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page(s)

1760-4

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cites work

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ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain

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The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle

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Np95 is a histone-binding protein endowed with ubiquitin ligase activity

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Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation

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ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

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Replication-independent chromatin loading of Dnmt1 during G2 and M phases

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Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation

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Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation

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Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

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Transcription of IAP endogenous retroviruses is constrained by cytosine methylation

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Epigenetic inheritance in plants.

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Epigenetic decisions in mammalian germ cells.

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The SRA methyl-cytosine-binding domain links DNA and histone methylation

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VIM1, a methylcytosine-binding protein required for centromeric heterochromatinization

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Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry

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Overexpression of NP95 mRNA by tumor promoters in the promotion phase of a two-stage BALB/3T3 cell transformation assay

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Np95 is implicated in pericentromeric heterochromatin replication and in major satellite silencing

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Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks

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DNA methylation in mouse A-repeats in DNA methyltransferase-knockout ES cells and in normal cells determined by bisulfite genomic sequencing

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Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells

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A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

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Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci

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Dynamic changes in subnuclear NP95 location during the cell cycle and its spatial relationship with DNA replication foci

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Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival

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DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells

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The characterization of the monoclonal antibody Th-10a, specific for a nuclear protein appearing in the S phase of the cell cycle in normal thymocytes and its unregulated expression in lymphoma cell lines

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