Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain (Q24629593)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19489738%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

review article

1 reference

title

Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19489738%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

0 references

1

1 reference

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29 January 2020

author name string

Rebekkah W Halford

2

1 reference

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29 January 2020

Denise M O Ramirez

3

1 reference

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29 January 2020

Rahul Shah

4

1 reference

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29 January 2020

Tiina Kotti

5

1 reference

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29 January 2020

language of work or name

English

0 references

publication date

1 January 2009

1 reference

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29 January 2020

number of pages

24

1 reference

Annual Review of Biochemistry

inferred from page(s)

published in

1 reference

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29 January 2020

volume

78

1 reference

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29 January 2020

issue

1

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page(s)

1017-1040

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Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

29 January 2020

cites work

1 reference

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Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol

7 April 2017

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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

7 April 2017

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cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism

7 April 2017

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7 April 2017

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Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina

7 April 2017

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Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer's disease in Chinese

7 April 2017

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Polymorphisms of the cholesterol 24-hydroxylase (CYP46A1) gene and the risk of Alzheimer's disease in a Chinese population

7 April 2017

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LXRS and FXR: the yin and yang of cholesterol and fat metabolism

7 April 2017

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Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes

7 April 2017

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Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease

7 April 2017

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Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modifications

7 April 2017

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Differential expression of cholesterol hydroxylases in Alzheimer's disease

7 April 2017

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Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain

7 April 2017

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Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

7 April 2017

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Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism

7 April 2017

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Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease

7 April 2017

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Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

7 April 2017

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Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease

7 April 2017

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Apolipoprotein E: far more than a lipid transport protein

7 April 2017

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Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

7 April 2017

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Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man

7 April 2017

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De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase

7 April 2017

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Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways

7 April 2017

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Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

7 April 2017

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The blood-brain barrier in health and chronic neurodegenerative disorders

7 April 2017

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Protein sensors for membrane sterols

7 April 2017

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Structure and function of dendritic spines

7 April 2017

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Long-term potentiation--a decade of progress?

7 April 2017

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Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

7 April 2017

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Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

27 September 2017

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Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

27 September 2017

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Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step

27 September 2017

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Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry

27 September 2017

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A neuroscientist's guide to lipidomics.

27 September 2017

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Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway

27 September 2017

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What common structural features and variations of mammalian P450s are known to date?

27 September 2017

1 reference

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Endocannabinoid-mediated synaptic plasticity in the CNS.

27 September 2017

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Turnover of brain mitochondrial membrane lipids

27 September 2017

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Brain cholesterol turnover required for geranylgeraniol production and learning in mice

27 September 2017

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Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.

27 September 2017

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Cholesterol homeostasis in neurons and glial cells

27 September 2017

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Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

27 September 2017

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High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs.

27 September 2017

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Structural and functional aspects of the blood-brain barrier.

27 September 2017

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The Structure and Function of Proline Recognition Domains

27 September 2017

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Role of cholesterol in synapse formation and function

27 September 2017

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Metabolism of 4 beta -hydroxycholesterol in humans.

27 September 2017

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Endocannabinoid signaling in the brain

27 September 2017

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Cholesterol metabolism in the brain

27 September 2017

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27 September 2017

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Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse

27 September 2017

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The molecular basis of dominance.

27 September 2017

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27 September 2017

Brain Sterol Metabolism

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Heterosynaptic depression: a postsynaptic correlate of long-term potentiation

27 September 2017

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Novel pathways for elimination of cholesterol by extrahepatic formation of side-chain oxidized oxysterols.

27 September 2017

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Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors.

27 September 2017

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Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.

30 May 2018

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Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice.

30 May 2018

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Sources of cholesterol during development of the rat fetus and fetal organs.

30 May 2018

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Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE.

30 May 2018

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Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat.

30 May 2018

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24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver

30 May 2018

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Sterol metabolism. V. A chromatographic examination of human brain sterols

30 May 2018

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24-Hydroxycholesterol levels in human brain

30 May 2018

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Sterol metabolism XXVIII. Biosynthesis and accumulation of cholest-5-ene-3β, 24-diol (cerebrosterol) in developing rat brain

30 May 2018

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Biosynthesis of cholest-5-ene-3beta, 24-diol (cerebrosterol) by bovine cerebral cortical microsomes

30 May 2018

1 reference

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Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation

30 May 2018

1 reference

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Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese patients.

30 May 2018

1 reference

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Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment?

28 November 2018

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CYP46 T/C polymorphism is not associated with Alzheimer's dementia in a population from Hungary.

28 November 2018

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Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis.

28 November 2018

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Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients

28 November 2018

1 reference

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Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease

28 November 2018

1 reference

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Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse

28 November 2018

1 reference

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Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration

28 November 2018

1 reference

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Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR.

28 November 2018

1 reference

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Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers.

28 November 2018

1 reference

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On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function.

28 November 2018

1 reference

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Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis

28 November 2018

1 reference

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Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

28 November 2018

1 reference

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24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

28 November 2018

1 reference

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From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans

28 November 2018

1 reference

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Transport of side-chain oxidized oxysterols in the human circulation

28 November 2018

1 reference

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Preferential utilization of newly synthesized cholesterol for brain growth in neonatal lambs.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837268

High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837268

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837268

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice.

28 November 2018

1 reference

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Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique: cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice

28 November 2018

1 reference

12 December 2020

Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol

1 reference

12 December 2020

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface

1 reference

12 December 2020

Excretion of 3beta-hydroxy-5-cholenoic and 3a-hydroxy-5a-cholanoic acids in urine of infants with biliary atresia

1 reference

12 December 2020

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

1 reference

12 December 2020

Identification of 22-, 24- and 26-Hydroxycholesterol in the Steroid Sulphate Fraction of Faeces from Infants

1 reference

12 December 2020

Absolute rates of cholesterol synthesis in extrahepatic tissues measured with 3H-labeled water and 14C-labeled substrates

1 reference

12 December 2020

[On the occurrence of dihydroxysterins in the human brain]

1 reference

12 December 2020

Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry

1 reference

12 December 2020

[Fractionation of "neutral trace lipids" from bovine and rabbit brain]

1 reference

12 December 2020

Use of an 18O2 inhalation technique and mass isotopomer distribution analysis to study oxygenation of cholesterol in rat. Evidence for in vivo formation of 7-oxo-, 7 beta-hydroxy-, 24-hydroxy-, and 25-hydroxycholesterol

1 reference

12 December 2020

Cholesterol for synthesis of myelin is made locally, not imported into brain

1 reference

12 December 2020

10.1146/ANNUREV.BIOCHEM.78.072407.103859

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19489738%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19489738%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

19489738

2 references