Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation (Q27639262)

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Peter Cron

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Vivienne Thompson

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Valerie M Good

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Daniel Hess

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David Barford

Mechanism of activation of protein kinase B by insulin and IGF-1

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language of work or name

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June 2002

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published in

Molecular Cell

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volume

9

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issue

6

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page(s)

1227-40

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cites work

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7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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7 January 2021

Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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ALSCRIPT: a tool to format multiple sequence alignments

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

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7 January 2021

Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state

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7 January 2021

Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: a thermodynamic study

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7 January 2021

Ten years of protein kinase B signalling: a hard Akt to follow

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7 January 2021

Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain

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7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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7 January 2021

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

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7 January 2021

Cellular survival: a play in three Akts

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An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

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The Catalytic Subunit of Dictyostelium cAMP-Dependent Protein Kinase. Role of the N-Terminal Domain and of the C-Terminal Residues in Catalytic Activity and Stability

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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

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7 January 2021

Analysis of protein kinase B/Akt

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

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Active and inactive protein kinases: structural basis for regulation

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Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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7 January 2021

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

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7 January 2021

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal

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7 January 2021

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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Raster3D Version 2.0. A program for photorealistic molecular graphics

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

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Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

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Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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AKT plays a central role in tumorigenesis

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7 January 2021

The PI3K-PDK1 connection: more than just a road to PKB

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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Analytical properties of the nanoelectrospray ion source

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Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli

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Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

release_dkcedr2gkvcfzcqr2mqdea2gyq

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/dkcedr2gkvcfzcqr2mqdea2gyq

24 November 2022

mapped directly with Wikidata item

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Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12086620

1 reference

Consolidated OpenCitations Corpus – April 2017