A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. (Q34025724)

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English	A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11929966%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status (English)

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8 December 2019

DNA methylation

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Gregory Dolnikowski

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8 December 2019

Pamela J Bagley

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8 December 2019

Oliviero Olivieri

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8 December 2019

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Jacob Selhub

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8 December 2019

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Paul F Jacques

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8 December 2019

Irwin H. Rosenberg

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Irwin H Rosenberg

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8 December 2019

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Simonetta Friso

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8 December 2019

Sang-Woon Choi

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8 December 2019

Domenico Girelli

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8 December 2019

Joel B Mason

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8 December 2019

Roberto Corrocher

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8 December 2019

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2 April 2002

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8 December 2019

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Proceedings of the National Academy of Sciences of the United States of America

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8 December 2019

99

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8 December 2019

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8 December 2019

5606-5611

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8 December 2019

C(m)C(a/t)GG methylation: a new epigenetic mark in mammalian DNA?

1 reference

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5 July 2018

CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing

1 reference

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5 July 2018

The role of DNA methylation in mammalian epigenetics

1 reference

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5 July 2018

The mechanism of DNA cytosine-5 methylation. Kinetic and mutational dissection of Hhai methyltransferase

1 reference

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5 July 2018

Biological and clinical implications of the MTHFR C677T polymorphism

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5 July 2018

Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.

1 reference

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5 July 2018

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia

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5 July 2018

DNA methylation in health and disease

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5 July 2018

The DNA methyltransferases of mammals

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5 July 2018

The controversy over homocysteine and cardiovascular risk

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5 July 2018

5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review

1 reference

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5 July 2018

Folate and carcinogenesis: an integrated scheme

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5 July 2018

DNA methylation analysis: a review of current methodologies

1 reference

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5 July 2018

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

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5 July 2018

Methylation-induced repression--belts, braces, and chromatin

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5 July 2018

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

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5 July 2018

Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults

1 reference

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5 July 2018

Epigenetics: regulation through repression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Homocysteine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Cancer epigenetics comes of age

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5 July 2018

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1 reference

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5 July 2018

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

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The implications of genetic diversity for nutrient requirements: the case of folate

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5 July 2018

Alterations in DNA methylation: a fundamental aspect of neoplasia

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5 July 2018

The 677C-->T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Altered DNA methylation and genome instability: a new pathway to cancer?

1 reference

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5 July 2018

Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate

1 reference

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5 July 2018

Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency.

1 reference

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5 July 2018

Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma

1 reference

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5 July 2018

Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification

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5 July 2018

CpNpG methylation in mammalian cells

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5 July 2018

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1 reference

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1 reference

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5 July 2018

CpG-rich islands and the function of DNA methylation

1 reference

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5 July 2018

Folate status assessment

1 reference

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5 July 2018

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1 reference

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5 July 2018

The essentials of DNA methylation

1 reference

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1 reference

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5 July 2018

Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.

1 reference

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29 October 2018

Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

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inferred from PubMed ID database lookup

Highly sensitive and simple liquid chromatographic determination in plasma of B6 vitamers, especially pyridoxal 5'-phosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine and atherothrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of folate form distribution by affinity followed by reversed- phase chromatography with electrical detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation meets genomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA modification mechanisms and gene activity during development

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation and enzymatic hydrolysis of DNA and RNA for mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrasonically assisted electrospray ionization for LC/MS determination of nucleosides from a transfer RNA digest

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1073/PNAS.062066299

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11929966%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

2002PNAS...99.5606F

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8 December 2019

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8 December 2019

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