Pharmacogenetics of the arylamine N-acetyltransferases. (Q34624647)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11990379%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

review article

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title

Pharmacogenetics of the arylamine N-acetyltransferases (English)

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10 December 2019

author name string

S Boukouvala

series ordinal

2

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10 December 2019

R F Minchin

series ordinal

4

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10 December 2019

publication date

1 January 2002

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The Pharmacogenomics Journal

10 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11990379%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

volume

2

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10 December 2019

issue

1

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10 December 2019

page(s)

30-42

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Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases

10 December 2019

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Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation

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Chromosomal localization of human genes for arylamine N-acetyltransferase

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Molecular abnormalities associated with secretory carcinomas of the breast

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Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression

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Allelic loss on chromosome arm 8p: analysis of sporadic epithelial ovarian tumors.

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Nomenclature for N-acetyltransferases

21 January 2018

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Structure of arylamine N-acetyltransferase reveals a catalytic triad

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Update on consensus arylamine N-acetyltransferase gene nomenclature

21 January 2018

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Construction of Syrian hamster lines congenic at the polymorphic acetyltransferase locus (NAT2): acetylator genotype-dependent N- and O-acetylation of arylamine carcinogens

21 January 2018

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Longitudinal distribution of arylamine N-acetyltransferases in the intestine of the hamster, mouse, and rat. Evidence for multiplicity of N-acetyltransferases in the intestine.

21 January 2018

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Acetylation of procainamide and isoniazid by a rat liver-N-acetyl-transferase

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Eubacterial arylamine N-acetyltransferases - identification and comparison of 18 members of the protein family with conserved active site cysteine, histidine and aspartate residues

21 January 2018

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Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid

21 January 2018

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Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases

21 January 2018

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Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2.

21 January 2018

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N-acetylation pharmacogenetics: a gene deletion causes absence of arylamine N-acetyltransferase in liver of slow acetylator rabbits

21 January 2018

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Nucleotide sequence of a full-length cDNA for arylamine N-acetyltransferase from rabbit liver

21 January 2018

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Molecular mechanism of slow acetylation of drugs and carcinogens in humans

21 January 2018

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Preliminary phenotypic map of chromosome 4p16 based on 4p deletions.

21 January 2018

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Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver

21 January 2018

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Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases.

21 January 2018

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Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis

21 January 2018

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Novel human N-acetyltransferase 2 alleles that differ in mechanism for slow acetylator phenotype

21 January 2018

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Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes.

21 January 2018

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21 January 2018

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Molecular mechanisms of genetic polymorphisms of drug metabolism

21 January 2018

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Genetic susceptibility and carcinogen-DNA adduct formation in human urinary bladder carcinogenesis

21 January 2018

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Correlation between genotype and phenotype of the human arylamine N-acetyltransferase type 1 (NAT1).

21 January 2018

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Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay

21 January 2018

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Genetically determined variability in acetylation and oxidation. Therapeutic implications

21 January 2018

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Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals

21 January 2018

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An international literature survey of "IARC Group I carcinogens" reported in mainstream cigarette smoke

21 January 2018

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Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999.

21 January 2018

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N-Acetyltransferase phenotype and risk in urinary bladder cancer: approaches in molecular epidemiology. Preliminary results in Sweden and Denmark

21 January 2018

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N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review

21 January 2018

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Relationship between acetylator status, smoking, and diet and colorectal cancer risk in the north-east of England

21 January 2018

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Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues.

21 January 2018

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Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease

21 January 2018

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Variability and validity of polymorphism association studies in Parkinson's disease

21 January 2018

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N-acetyltransferases: pharmacogenetics and clinical consequences of polymorphic drug metabolism

21 January 2018

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21 January 2018

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The contribution of N-hydroxylation and acetylation to dapsone pharmacokinetics in normal subjects

21 January 2018

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Development of dapsone toxicity in patients with inflammatory dermatoses: activity of acetylation and hydroxylation of dapsone as risk factors.

21 January 2018

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21 January 2018

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Genotyping of the arylamine N-acetyltransferase polymorphism in the prediction of idiosyncratic reactions to trimethoprim-sulfamethoxazole in infants

21 January 2018

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Role of polymorphic and monomorphic human arylamine N-acetyltransferases in determining sulfamethoxazole metabolism.

21 January 2018

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Effect of acetylator phenotype on efficacy and toxicity of sulphasalazine in rheumatoid arthritis

21 January 2018

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Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations

21 January 2018

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7 January 2021

Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe

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7 January 2021

Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas.

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7 January 2021

Effect of streptolysin-O-on rat hepatic acetyl coenzyme-A: arylamine N-acetyltransferase and cytochrome P-450 2B 1/2 activities ex vivo

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7 January 2021

Purification and biochemical properties of an N-hydroxyarylamine O-acetyltransferase from Escherichia coli

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7 January 2021

Evidence for arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori

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7 January 2021

Mapping AAC1 AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours

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7 January 2021

Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro

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7 January 2021

Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase

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7 January 2021

Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and deactivation of aromatic amine carcinogens

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7 January 2021

Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene

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7 January 2021

Cytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes

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7 January 2021

Human acetyltransferase polymorphisms

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7 January 2021

Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans

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7 January 2021

Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants.

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7 January 2021

Enzyme kinetic properties of human recombinant arylamine N-acetyltransferase 2 allotypic variants expressed in Escherichia coli

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7 January 2021

Characterization of human lymphocyte N-acetyltransferase and its relationship to the isoniazid acetylator polymorphism

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7 January 2021

Arylamine N-acetyltransferase in human red blood cells

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7 January 2021

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7 January 2021

Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus

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7 January 2021

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7 January 2021

Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1

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7 January 2021

Arylamine N-acetyltransferase 1 (NAT1) genotypes in a Lebanese population

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7 January 2021

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7 January 2021

Benzidine-DNA adduct levels in human peripheral white blood cells significantly correlate with levels in exfoliated urothelial cells

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7 January 2021

Aromatic amine acetyltransferase as a marker for colorectal cancer: environmental and demographic associations

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7 January 2021

Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells

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7 January 2021

The ability of two cooked food mutagens to induce aberrant crypt foci in mice

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7 January 2021

Association between acetylator genotype and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) DNA adduct formation in colon and prostate of inbred Fischer 344 and Wistar Kyoto rats

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7 January 2021

Acetylator phenotype and the antihypertensive response to hydralazine

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7 January 2021

Hydralazine kinetics after single and repeated oral doses

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7 January 2021

Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity

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7 January 2021

Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection

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7 January 2021

Paradoxical relationship between acetylator phenotype and amonafide toxicity

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7 January 2021

Population pharmacodynamic study of amonafide: a Cancer and Leukemia Group B study

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7 January 2021

Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender.

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7 January 2021

Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance

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7 January 2021

Intestinal microflora enhances formation of DNA adducts following administration of 2-NF and 2-AAF

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7 January 2021

Acetylator phenotype in patients with hydralazine-induced lupoid syndrome

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7 January 2021

The arylamine N-acetyltransferase (NAT2) polymorphism and the risk of adverse reactions to co-trimoxazole in children

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7 January 2021

Influence of acetylator status on sulphasalazine efficacy and toxicity in patients with rheumatoid arthritis

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7 January 2021

Autoallergic reactions induced by procainamide

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7 January 2021

Influence of acetylator phenotype on antidepressant effects of phenelzine

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7 January 2021

The relationship between acetylator status and inhibition of monoamine oxidase, excretion of free drug and antidepressant response in depressed patients on phenelzine

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7 January 2021

Acetylator phenotype in patients with p-phenylenediamine allergy

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7 January 2021

Identifiers

DOI

10.1038/SJ.TPJ.6500053

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11990379%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 December 2019

1043593908

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