Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus (Q34920713)

5 August 2017

title

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus (English)

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5 August 2017

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11

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5 August 2017

Nathalie Acevedo

1

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Dario Greco

Dario Greco

3

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Göran Pershagen

Göran Pershagen

7

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Erik Melén

9

Erik Melén

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5 August 2017

12

Cilla Söderhäll

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5 August 2017

10

Annika Scheynius

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5 August 2017

2

Lovisa E Reinius

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Christina Orsmark Pietras

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5

Christina Orsmark-Pietras

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8

Gunilla Hedlin

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5 August 2017

Anna Gref

4

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5 August 2017

Helena Persson

6

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5 August 2017

publication date

25 September 2014

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5 August 2017

published in

Human Molecular Genetics

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5 August 2017

volume

24

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5 August 2017

issue

3

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5 August 2017

page(s)

875-890

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A promoter-level mammalian expression atlas

5 August 2017

cites work

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Functional analysis of the impact of ORMDL3 expression on inflammation and activation of the unfolded protein response in human airway epithelial cells

8 July 2018

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Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines

8 July 2018

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8 July 2018

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Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion

8 July 2018

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Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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A sequence variant on 17q21 is associated with age at onset and severity of asthma

8 July 2018

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8 July 2018

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8 July 2018

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Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

8 July 2018

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8 July 2018

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Disentangling molecular relationships with a causal inference test

8 July 2018

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Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma

8 July 2018

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Effect of 17q21 variants and smoking exposure in early-onset asthma

8 July 2018

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8 July 2018

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ORMDL3 gene is associated with asthma in three ethnically diverse populations

8 July 2018

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Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

8 July 2018

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8 July 2018

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8 July 2018

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ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins

8 July 2018

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8 July 2018

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17q12-21 and asthma: interactions with early-life environmental exposures

8 July 2018

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Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma-like symptoms

21 January 2018

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21 January 2018

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DNA hypomethylation at ALOX12 is associated with persistent wheezing in childhood

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU479

Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU479

17q21 variants modify the association between early respiratory infections and asthma

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU479

Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU479

Problematic severe asthma: a proposed approach to identifying children who are severely resistant to therapy.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU479

Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU479

Elevated peripheral allergen-specific T cell response is crucial for a positive atopy patch test reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU479

Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291244

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry

26 October 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU479

Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU479

Classical and causal inference approaches to statistical mediation analysis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25256354

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25256354

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

ORMDL3 modulates store-operated calcium entry and lymphocyte activation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25256354

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDU479

1 reference

5 August 2017

1 reference

5 August 2017

1 reference