DNA methylation and gene silencing in cancer (Q36338042)

13 August 2017

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title

DNA methylation and gene silencing in cancer (English)

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13 August 2017

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Stephen B Baylin

1

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13 August 2017

publication date

1 December 2005

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Nature Clinical Practice Oncology

13 August 2017

published in

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13 August 2017

volume

2 Suppl 1

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13 August 2017

page(s)

S4-11

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Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.

13 August 2017

cites work

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https://api.crossref.org/works/10.1038%2FNCPONC0354

DNA methylation patterns and epigenetic memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

The fundamental role of epigenetic events in cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Gene silencing in cancer in association with promoter hypermethylation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

DNA methylation as a therapeutic target in hematologic disorders: recent results in older patients with myelodysplasia and acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

The DNA methyltransferases of mammals

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

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https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

CpG methylation is maintained in human cancer cells lacking DNMT1.

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https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

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https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

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https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Translating the Histone Code

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https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly

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https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries

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https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Methylation-induced repression--belts, braces, and chromatin

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https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Clinical development of histone deacetylase inhibitors as anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Two genetic hits (more or less) to cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Hypermethylation of tumor suppressor genes in cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

DNA methylation as a target for drug design

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

DNA methylation: past, present and future directions

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Targeting hypomethylation of DNA to achieve cellular differentiation in myelodysplastic syndromes (MDS).

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

DNA methyltransferase inhibitors-state of the art.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0354

7 January 2021

Identifiers

DOI

10.1038/NCPONC0354

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Dimensions Publication ID

13 August 2017

1034769071

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