New pathophysiological insights and modern treatment of IBD. (Q37705033)

22 August 2017

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title

New pathophysiological insights and modern treatment of IBD. (English)

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22 August 2017

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2

Markus F Neurath

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22 August 2017

Matthias A Engel

1

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22 August 2017

publication date

9 March 2010

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Journal of Gastroenterology

22 August 2017

published in

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22 August 2017

volume

45

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22 August 2017

issue

6

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22 August 2017

page(s)

571-583

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Bacterial flagellin is a dominant antigen in Crohn disease.

22 August 2017

cites work

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CD4 antibody treatment in patients with active Crohn's disease: a phase 1 dose finding study

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Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure

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The prevention and treatment of murine colitis using gene therapy with adenoviral vectors encoding IL-10.

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The genetics of inflammatory bowel disease

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CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease

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12 December 2020

Mucosal flora in inflammatory bowel disease

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12 December 2020

A comparison of budesonide and mesalamine for active Crohn's disease. International Budesonide-Mesalamine Study Group.

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12 December 2020

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

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12 December 2020

Failure of single-toxin assays to detect clostridium difficile infection in pediatric inflammatory bowel disease

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12 December 2020

Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease

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12 December 2020

Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine

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12 December 2020

A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis

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12 December 2020

Clinical relevance of serum interleukin-6 in Crohn's disease: single point measurements, therapy monitoring, and prediction of clinical relapse

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12 December 2020

Decreased gastrointestinal absorption of peroral polyethyleneglycols (PEG 1000) in Crohn's disease. A sign of jejunal abnormality

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12 December 2020

Frequently relapsing Crohn's disease is characterized by persistent elevation in interleukin-6 and soluble interleukin-2 receptor serum levels during remission

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12 December 2020

Granulomas do not affect postoperative recurrence rates in Crohn's disease

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12 December 2020

Prevalence of cytomegalovirus infection in severe refractory ulcerative and Crohn's colitis

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12 December 2020

Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model

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12 December 2020

Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease.

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12 December 2020

Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival

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12 December 2020

Outcome of cytomegalovirus infections in patients with inflammatory bowel disease

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12 December 2020

Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor

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12 December 2020

Mycophenolate mofetil versus azathioprine in patients with chronic active ulcerative colitis: a 12-month pilot study

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12 December 2020

Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients

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12 December 2020

Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations.

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12 December 2020

The fundamental basis of inflammatory bowel disease

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12 December 2020

The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review

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12 December 2020

A comparison of budesonide with prednisolone for active Crohn's disease

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12 December 2020

A prospective comparison study of MRI versus small bowel follow-through in recurrent Crohn's disease.

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12 December 2020

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

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12 December 2020

Relevance of serologic studies in inflammatory bowel disease

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12 December 2020

Cytomegalovirus infection in patients with inflammatory bowel disease

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12 December 2020

Cortisone and corticotrophin in ulcerative colitis.

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12 December 2020

Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial

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12 December 2020

IL-6 is required for the development of Th1 cell-mediated murine colitis

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12 December 2020

Histologic Features of Mycophenolate Mofetil-Related Colitis: A Graft-Versus-Host Disease-Like Pattern

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12 December 2020

Diagnostics of inflammatory bowel disease

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12 December 2020

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

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12 December 2020

Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients.

1 reference

12 December 2020

Effect of treatment on symptoms and quality of life in patients with ulcerative colitis: comparative trial of hydrocortisone acetate foam and prednisolone 21-phosphate enemas

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12 December 2020

6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity

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12 December 2020

Abdominal ultrasound in the assessment of extent and activity of Crohn's disease: clinical significance and implication of bowel wall thickening

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12 December 2020

Nature and course of pancreatitis caused by 6-mercaptopurine in the treatment of inflammatory bowel disease

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12 December 2020

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12 December 2020

Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease

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12 December 2020

In vivo and in vitro gene transfer and expression in rat intestinal epithelial cells by E1-deleted adenoviral vector

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12 December 2020

Gut epithelial cells as targets for gene therapy of hemophilia

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12 December 2020

A controlled trial of alternate day prednisolone as a maintenance treatment for ulcerative colitis in remission

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12 December 2020

The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants.

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12 December 2020

Crohn's-like changes in the colon due to mycophenolate?

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12 December 2020

Effect of sulphasalazine in patients with active Crohn's disease: a controlled double-blind study

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12 December 2020

Identification of a novel bacterial sequence associated with Crohn's disease

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12 December 2020

Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.

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12 December 2020

The role of microbes in Crohn's disease

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12 December 2020

Inflammatory bowel disease in Iceland, 1990-1994: a prospective, nationwide, epidemiological study.

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12 December 2020

Clostridium difficile associated diarrhoea: a role in inflammatory bowel disease?

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12 December 2020

Budesonide versus prednisone in the treatment of active Crohn's disease. The Israeli Budesonide Study Group

1 reference

12 December 2020

A simple method for assessing intestinal inflammation in Crohn's disease

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12 December 2020

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

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12 December 2020

Cdcs1, a Major Colitogenic Locus in Mice, Regulates Innate and Adaptive Immune Response to Enteric Bacterial Antigens

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12 December 2020

Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent

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12 December 2020

Intensive intravenous treatment of ulcerative colitis

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12 December 2020

Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease

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12 December 2020

Human APC gene expression in rodent colonic epithelium in vivo using liposomal gene delivery

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12 December 2020

Clostridium difficile-associated diarrhea and colitis: clinical manifestations, diagnosis, and treatment

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12 December 2020

The effect of elemental diet on intestinal permeability and inflammation in Crohn's disease

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12 December 2020

Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease. German/Austrian Budesonide Study Group

1 reference

12 December 2020

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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12 December 2020

Microbial influences in inflammatory bowel diseases

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12 December 2020

Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study

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12 December 2020

Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease

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12 December 2020

Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis

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12 December 2020

Tumour necrosis factor α and interleukin 1β in relapse of Crohn's disease

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12 December 2020

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

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12 December 2020

Tumor inhibitory activity of anti-ras ribozymes delivered by retroviral gene transfer

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12 December 2020

The soluble interleukin-6 receptor is generated by shedding

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12 December 2020

Ocular manifestations of inflammatory bowel disease

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12 December 2020

Role of US in detection of Crohn disease: meta-analysis

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12 December 2020

Adenovirus-mediated transduction of intestinal cells in vivo

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12 December 2020

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

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12 December 2020

Peroral gene therapy of lactose intolerance using an adeno-associated virus vector

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12 December 2020

Diagnostic significance of epithelioid granulomas in Crohn's disease in children. Multicenter Paediatric Crohn's Disease Study Group

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12 December 2020

The effectiveness of budesonide therapy for Crohn's disease

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12 December 2020

Incidence and prevalence of inflammatory bowel disease in Japan: nationwide epidemiological survey during the year 1991

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12 December 2020

Role of integrin expression in adenovirus-mediated gene delivery to the intestinal epithelium

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12 December 2020

Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences

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12 December 2020

PREDNISONE AS MAINTENANCE TREATMENT FOR ULCERATIVE COLITIS IN REMISSION

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12 December 2020

Clostridium difficile and inflammatory bowel disease

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12 December 2020

Racial differences in the prevalence of ulcerative colitis and Crohn's disease in Singapore

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12 December 2020

The prevalence of genetic and serologic markers in an unselected European population-based cohort of IBD patients

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12 December 2020

Oral contrast enhanced bowel ultrasonography in the assessment of small intestine Crohn's disease. A prospective comparison with conventional ultrasound, x ray studies, and ileocolonoscopy

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12 December 2020

Rediscovering mycophenolic acid: a review of its mechanism, side effects, and potential uses

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12 December 2020

Comparison of corticosteroid and sulphasalazine therapy in ulcerative colitis

1 reference

12 December 2020

Beclomethasone dipropionate (3 mg) versus 5-aminosalicylic acid (2 g) versus the combination of both (3 mg/2 g) as retention enemas in active ulcerative proctitis

1 reference

12 December 2020

Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group

1 reference

12 December 2020

Association of Clostridium difficile toxin with symptomatic relapse of chronic inflammatory bowel disease

1 reference

12 December 2020

A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice

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12 December 2020

Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma

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12 December 2020

Biological therapies for inflammatory bowel diseases

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12 December 2020

Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens

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12 December 2020

Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease

1 reference

12 December 2020

Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease

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12 December 2020

Ulcerative colitis. Acute episode

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12 December 2020

Oral budesonide versus prednisolone in patients with active extensive and left-sided ulcerative colitis

1 reference

12 December 2020

Intestinal function and morphology after ex vivo irradiated small bowel transplantation

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12 December 2020

Liposome mediated gene transfer into GH3 cells, and rat brain, liver and gut: comparison of different polar or aliphatic domains

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12 December 2020

Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan

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12 December 2020

Increased expression of interleukin 17 in inflammatory bowel disease

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12 December 2020

Calprotectin is a stronger predictive marker of relapse in ulcerative colitis than in Crohn's disease

1 reference

12 December 2020

Corticotropin versus hydrocortisone in the intravenous treatment of ulcerative colitis. A prospective, randomized, double-blind clinical trial

1 reference

12 December 2020

An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy

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12 December 2020

Serologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn's disease and ulcerative colitis: diagnostic value and correlation with disease phenotype.

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12 December 2020

Unravelling the pathogenesis of inflammatory bowel disease

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12 December 2020

Non-invasive evaluation of activity in inflammatory bowel disease by power Doppler sonography.

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12 December 2020

Critical role of IL-17 receptor signaling in acute TNBS-induced colitis

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12 December 2020

Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis

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12 December 2020

Passage of molecules through the wall of the gastrointestinal tract. Intestinal permeability to polyethyleneglycol 1 000 in patients with Crohn's disease

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12 December 2020

Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease

1 reference

12 December 2020

A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas.

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12 December 2020

Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors

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12 December 2020

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

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12 December 2020

Liposome mediated in vivo gene transfer into different tissues of the gastrointestinal tract

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12 December 2020

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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12 December 2020

Candida albicans Is an Immunogen for Anti–Saccharomyces cerevisiae Antibody Markers of Crohn’s Disease

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12 December 2020

Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc

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12 December 2020

Low bone mineral density in Crohn's disease, but not in ulcerative colitis, at diagnosis

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12 December 2020

Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease

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12 December 2020

Maintenance of functional stem cells in isolated and cultured adult intestinal epithelium

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12 December 2020

Cytomegalovirus colitis complicating ulcerative colitis in the steroid-naive patient

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12 December 2020

Gastrointestinal stem cells

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12 December 2020

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

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12 December 2020

Comparison of budesonide and 5-aminosalicylic acid enemas in active distal ulcerative colitis

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12 December 2020

Anti-outer membrane of porin C and anti-I2 antibodies in indeterminate colitis

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12 December 2020

Crohn disease: magnetic resonance enteroclysis

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12 December 2020

Sonographic evaluation of inflammatory bowel disease: a prospective, blinded, comparative study

1 reference

12 December 2020

IL-10 gene therapy prevents TNBS-induced colitis

1 reference

12 December 2020

Budesonide versus prednisolone retention enemas in active distal ulcerative colitis

1 reference

12 December 2020

Pathogenesis and clinical manifestations of Clostridium difficile diarrhea and colitis

1 reference

12 December 2020

Further experience in the treatment of severe attacks of ulcerative colitis

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12 December 2020

Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

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12 December 2020

Interleukin 10 gene transfer prevents experimental colitis in rats

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12 December 2020

A high serum concentration of interleukin-6 is predictive of relapse in quiescent Crohn's disease

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12 December 2020

Increased gastric and intestinal permeability in patients with Crohn's disease

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12 December 2020

A review of immune modifier therapy for inflammatory bowel disease: azathioprine, 6-mercaptopurine, cyclosporine, and methotrexate.

1 reference

12 December 2020

Tumour necrosis factor and Crohn's disease

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12 December 2020

American Gastroenterological Association Institute technical review on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease

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12 December 2020

Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

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12 December 2020

Incidence and prevalence of ulcerative colitis in the Songpa-Kangdong District, Seoul, Korea, 1986-1997.

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12 December 2020

NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population.

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12 December 2020

6-mercaptopurine for the management of ulcerative colitis: a concept whose time has come

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12 December 2020

Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6

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12 December 2020

Intensive intravenous regimen for severe attacks of ulcerative colitis.

1 reference

12 December 2020

Treatment of Crohn's disease with anti-IL-6 receptor antibody.

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12 December 2020

10.1007/S00535-010-0219-3

Identifiers

DOI

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22 August 2017

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