Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. (Q40785589)

23 September 2017

title

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. (English)

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23 September 2017

E G Schuetz

1

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23 September 2017

S Strom

2

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23 September 2017

K Yasuda

3

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23 September 2017

V Lecureur

4

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23 September 2017

M Assem

5

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23 September 2017

C Brimer

6

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23 September 2017

J Lamba

7

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R B Kim

8

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23 September 2017

V Ramachandran

9

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23 September 2017

B J Komoroski

10

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23 September 2017

R Venkataramanan

11

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23 September 2017

H Cai

12

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23 September 2017

C J Sinal

13

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23 September 2017

F J Gonzalez

14

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23 September 2017

J D Schuetz

15

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23 September 2017

language of work or name

English

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publication date

16 August 2001

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

276

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23 September 2017

issue

42

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23 September 2017

page(s)

39411-39418

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Identification of a nuclear receptor for bile acids

23 September 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M106340200

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

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The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

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A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

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Identification of a locus for progressive familial intrahepatic cholestasis PFIC2 on chromosome 2q24

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Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis

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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

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Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat.

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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21 January 2018

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Regulation of multidrug resistance 2 P-glycoprotein expression by bile salts in rats and in primary cultures of rat hepatocytes

21 January 2018

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Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.

21 January 2018

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Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice

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MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

21 January 2018

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Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver

21 January 2018

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21 January 2018

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Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

21 January 2018

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Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow-up. A pilot study

21 January 2018

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The continuing importance of bile acids in liver and intestinal disease

21 January 2018

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P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

21 January 2018

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

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Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M106340200

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23 September 2017

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