Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. (Q47720762)

5 February 2018

title

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. (English)

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5 February 2018

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Pivniouk V

1

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5 February 2018

Tsitsikov E

2

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5 February 2018

Swinton P

3

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5 February 2018

Rathbun G

4

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5 February 2018

Alt FW

5

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5 February 2018

Geha RS

6

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5 February 2018

language of work or name

English

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publication date

1 July 1998

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5 February 2018

published in

Cell

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5 February 2018

volume

94

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5 February 2018

issue

2

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5 February 2018

page(s)

229-238

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5 February 2018

Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.

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Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

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The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci

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Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

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T cell antigen receptor signal transduction pathways

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Syk tyrosine kinase required for mouse viability and B-cell development

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7 January 2021

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

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7 January 2021

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

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7 January 2021

The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte

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Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

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Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

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Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.

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Blocked Ras activation in anergic CD4+ T cells

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Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation

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7 January 2021

Fyn can partially substitute for Lck in T lymphocyte development

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7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

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Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice

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7 January 2021

Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

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7 January 2021

The role of Grb2-associated proteins in T-cell activation

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Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon

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Regulation of thymocyte development through CD3: Functional dissociation between p56lck and CD3ζ in early thymic selection

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7 January 2021

T cell development in mice lacking the CD3-zeta/eta gene.

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Profound block in thymocyte development in mice lacking p56lck

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7 January 2021

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

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7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

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7 January 2021

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

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7 January 2021

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

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7 January 2021

Essential role for ZAP-70 in both positive and negative selection of thymocytes

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7 January 2021

Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2

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CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.

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Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

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7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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7 January 2021

Early T lymphocyte progenitors

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7 January 2021

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

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7 January 2021

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes

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7 January 2021

FcR gamma chain deletion results in pleiotrophic effector cell defects

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7 January 2021

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

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7 January 2021

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

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7 January 2021

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

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7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

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7 January 2021

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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7 January 2021

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

1 reference

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7 January 2021

Structure and function of the pre-T cell receptor

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7 January 2021

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981422-1

7 January 2021

Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981422-1

7 January 2021

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981422-1

7 January 2021

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981422-1

7 January 2021

10.1016/S0092-8674(00)81422-1

Identifiers

DOI

1 reference

5 February 2018

1 reference

5 February 2018