Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines (Q48154511)

9 February 2018

title

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines (English)

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9 February 2018

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7

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author name string

N Ishii

1

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9 February 2018

D Maier

2

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9 February 2018

A Merlo

3

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9 February 2018

M Tada

4

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9 February 2018

Y Sawamura

5

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A C Diserens

6

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9 February 2018

publication date

1 July 1999

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9 February 2018

published in

Brain Pathology

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9 February 2018

volume

9

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issue

3

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page(s)

469-479

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describes a project that uses

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Genetic instability leads to loss of both p53 alleles in a human glioblastoma

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

p53 protein accumulation and gene mutations in human glioma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Morphological, immunocytochemical and growth characteristics of three human glioblastomas established in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Constitutional p53 mutations associated with brain tumors in young adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

PTEN mutations in gliomas and glioneuronal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Intrinsic brain-stem tumors of childhood: surgical indications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

A simple p53 functional assay for screening cell lines, blood, and tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Frequent loss of the cyclin-dependent kinase-4 inhibitor gene in human gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Genetic alterations associated with the evolution and progression of astrocytic brain tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Establishment and characterization of five cell lines derived from human malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Clonality and stability of the p53 gene in human astrocytic tumor cells: quantitative analysis of p53 gene mutations by yeast functional assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Subsets of glioblastoma multiforme defined by molecular genetic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Field cancerisation and polyclonal p53 mutation in the upper aero- digestive tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1999.TB00536.X

10.1111/J.1750-3639.1999.TB00536.X

21 January 2018

Identifiers

DOI

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9 February 2018

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9 February 2018