A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity (Q56889692)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30174217%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

title

A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30174217%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

author name string

Prabhakaran Kumar

series ordinal

1

1 reference

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20 April 2020

Palash Bhattacharya

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30174217%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

Bellur S Prabhakar

series ordinal

3

1 reference

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20 April 2020

language of work or name

English

0 references

publication date

31 August 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30174217%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

published in

Journal of Autoimmunity

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30174217%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

volume

95

1 reference

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20 April 2020

page(s)

77-99

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A new analysis of allogeneic interactions

20 April 2020

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LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator

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Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines

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Identification of the 2B4 molecule as a counter-receptor for CD48

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Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor

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Engagement of the OX-40 receptor in vivo enhances antitumor immunity

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Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice

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Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

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Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor

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Adenovirus-mediated gene transfer of CTLA-4Ig fusion protein in the suppression of experimental autoimmune arthritis

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Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells

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CD30 signals integrate expression of cytotoxic effector molecules, lymphocyte trafficking signals, and signals for proliferation and apoptosis

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CD27 is required for generation and long-term maintenance of T cell immunity

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Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

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Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis.

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

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12 December 2020

CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

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12 December 2020

B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis

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12 December 2020

Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis

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12 December 2020

On the site and mode of antigen presentation for the initiation of clonal expansion of CD8 T cells specific for a natural tumor antigen

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12 December 2020

Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis

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12 December 2020

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

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12 December 2020

The molecular architecture of the TNF superfamily

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12 December 2020

Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis

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12 December 2020

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

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12 December 2020

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

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The B7-CD28 superfamily

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12 December 2020

Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis

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Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells

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Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers

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Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

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Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells

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Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)

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12 December 2020

Cutting edge: ligation of the glucocorticoid-induced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitis

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12 December 2020

Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells

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12 December 2020

Requirement for CD28 in the effector phase of allergic airway inflammation

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12 December 2020

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

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12 December 2020

The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells

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12 December 2020

PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

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12 December 2020

Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions

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12 December 2020

4-1BB-mediated immunotherapy of rheumatoid arthritis.

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12 December 2020

Role of LAG-3 in regulatory T cells.

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12 December 2020

Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223)

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12 December 2020

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

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12 December 2020

Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer

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12 December 2020

Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma

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12 December 2020

Constitutive expression and costimulatory function of LIGHT/TNFSF14 on human melanoma cells and melanoma-derived microvesicles.

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12 December 2020

Cellular and genetic mechanisms of self tolerance and autoimmunity

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12 December 2020

Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of inflammatory bowel disease

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12 December 2020

During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion

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12 December 2020

Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis

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12 December 2020

Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes

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12 December 2020

Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway

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12 December 2020

Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition

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12 December 2020

Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint

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12 December 2020

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells.

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12 December 2020

TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis

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12 December 2020

Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis.

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12 December 2020

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

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12 December 2020

Involvement of 4-1BB (CD137)-4-1BBligand interaction in the modulation of CD4 T cell-mediated inflammatory colitis

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12 December 2020

Activated CD4+CD25+ T cells selectively kill B lymphocytes

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12 December 2020

A molecular perspective of CTLA-4 function

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12 December 2020

Regulatory T cells, tumour immunity and immunotherapy

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12 December 2020

Tissue expression of PD-L1 mediates peripheral T cell tolerance.

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12 December 2020

Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity.

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Dysregulated T cell expression of TIM3 in multiple sclerosis

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GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice.

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12 December 2020

Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions.

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12 December 2020

Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease

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12 December 2020

Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis

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12 December 2020

Modulating protective and pathogenic CD4+ subsets via CD137 in type 1 diabetes

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12 December 2020

The PD-1/PD-L pathway is up-regulated during IL-12-induced suppression of EAE mediated by IFN-gamma

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12 December 2020

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

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12 December 2020

Immune surveillance of tumors

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12 December 2020

OX40 costimulation turns off Foxp3+ Tregs.

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12 December 2020

Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.

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12 December 2020

PD-1 and PD-1 ligands: from discovery to clinical application

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Role of endogenous 4-1BB in the development of systemic lupus erythematosus

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12 December 2020

Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells

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12 December 2020

Agonistic anti-4-1BB antibody promotes the expansion of natural regulatory T cells while maintaining Foxp3 expression

1 reference

12 December 2020

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

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12 December 2020

A two-step process for thymic regulatory T cell development.

1 reference

12 December 2020

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

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12 December 2020

TIM-4 expressed on APCs induces T cell expansion and survival

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12 December 2020

Bimodal regulation of T cell-mediated immune responses by TIM-4

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12 December 2020

Immune regulation and control of regulatory T cells by OX40 and 4-1BB

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12 December 2020

Revival of CD8+ Treg-mediated suppression

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12 December 2020

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

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CD28 controls differentiation of regulatory T cells from naive CD4 T cells

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12 December 2020

TIM-1 and TIM-3 proteins in immune regulation.

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12 December 2020

CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner

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12 December 2020

Decreased 4-1BB expression on CD4+CD25 high regulatory T cells in peripheral blood of patients with multiple sclerosis

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12 December 2020

Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism

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12 December 2020

CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial.

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PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.

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12 December 2020

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

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12 December 2020

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

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12 December 2020

Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.

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Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity

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Glucocorticoid-induced tumor necrosis factor receptor-related protein ligand subverts immunosurveillance of acute myeloid leukemia in humans

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Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation

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A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC

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Expression of adhesion molecules and ligands for activating and costimulatory receptors involved in cell-mediated cytotoxicity in a large panel of human melanoma cell lines

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CD28 and CTLA-4 coreceptor expression and signal transduction

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Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

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The significance of OX40 and OX40L to T-cell biology and immune disease.

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Immune regulation by 4-1BB and 4-1BBL: complexities and challenges

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12 December 2020

Sequence, structure, function, immunity: structural genomics of costimulation.

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12 December 2020

GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo.

1 reference

12 December 2020

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies

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12 December 2020

Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion

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12 December 2020

Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis

1 reference

12 December 2020

PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells

1 reference

12 December 2020

Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right

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12 December 2020

The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

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12 December 2020

T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment

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12 December 2020

Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target

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12 December 2020

HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation

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12 December 2020

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

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12 December 2020

The effects of PDL-Ig on collagen-induced arthritis

1 reference

12 December 2020

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS).

1 reference

12 December 2020

GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells

1 reference

12 December 2020

Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice

1 reference

12 December 2020

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

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12 December 2020

T cell Ig and mucin domain proteins and immunity

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12 December 2020

SLAM-family receptors: immune regulators with or without SAP-family adaptors

1 reference

12 December 2020

Control of immunity by the TNFR-related molecule OX40 (CD134)

1 reference

12 December 2020

OX40 is required for regulatory T cell-mediated control of colitis

1 reference

12 December 2020

LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites

1 reference

12 December 2020

Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation

1 reference

12 December 2020

The inhibitory pathway PD-1/PD-1 ligands is upregulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis

1 reference

12 December 2020

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

1 reference

12 December 2020

Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation

1 reference

12 December 2020

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

1 reference

12 December 2020

The PD-1 pathway in tolerance and autoimmunity

1 reference

12 December 2020

Role of CD27/CD70 pathway of activation in immunity and tolerance

1 reference

12 December 2020

Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells

1 reference

12 December 2020

Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice

1 reference

12 December 2020

Blockade of Programmed Death-1 in Young (New Zealand Black × New Zealand White)F1 Mice Promotes the Activity of Suppressive CD8+ T Cells That Protect from Lupus-Like Disease

1 reference

12 December 2020

A therapeutic OX40 agonist dynamically alters dendritic, endothelial, and T cell subsets within the established tumor microenvironment.

1 reference

12 December 2020

GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms

1 reference

12 December 2020

Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies

1 reference

12 December 2020

Cutting edge: TIGIT has T cell-intrinsic inhibitory functions

1 reference

12 December 2020

SLAM family receptors and SAP adaptors in immunity.

1 reference

12 December 2020

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

1 reference

12 December 2020

CD160: a unique activating NK cell receptor

1 reference

12 December 2020

Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function

1 reference

12 December 2020

Vstm3 is a member of the CD28 family and an important modulator of T-cell function

1 reference

12 December 2020

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway

1 reference

12 December 2020

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

1 reference

12 December 2020

B7-h2 is a costimulatory ligand for CD28 in human

1 reference

12 December 2020

Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production

1 reference

12 December 2020

Natural but not inducible regulatory T cells require TNF-alpha signaling for in vivo function

1 reference

12 December 2020

Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells

1 reference

12 December 2020

Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer

1 reference

12 December 2020

4-1BB triggering ameliorates experimental autoimmune encephalomyelitis by modulating the balance between Th17 and regulatory T cells

1 reference

12 December 2020

A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity

1 reference

12 December 2020

TNF receptor 1 deficiency increases regulatory T cell function in nonobese diabetic mice

1 reference

12 December 2020

PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells

1 reference

12 December 2020

Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells

1 reference

12 December 2020

Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses.

1 reference

12 December 2020

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

1 reference

12 December 2020

Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3

1 reference

12 December 2020

Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment

1 reference

12 December 2020

Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab is associated with a profound long-lasting depletion of Foxp3+ regulatory T cells: a mechanistic explanation for ipilimumab-induced severe enterocolitis?

1 reference

12 December 2020

Thymic and peripheral differentiation of regulatory T cells

1 reference

12 December 2020

New insights on OX40 in the control of T cell immunity and immune tolerance in vivo

1 reference

12 December 2020

Regulatory T cells: mechanisms of differentiation and function

1 reference

12 December 2020

Intratumor OX40 stimulation inhibits IRF1 expression and IL-10 production by Treg cells while enhancing CD40L expression by effector memory T cells

1 reference

12 December 2020

Receptors that interact with nectin and nectin-like proteins in the immunosurveillance and immunotherapy of cancer.

1 reference

12 December 2020

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

1 reference

12 December 2020

Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization

1 reference

12 December 2020

TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression

1 reference

12 December 2020

The TIGIT/CD226 axis regulates human T cell function

1 reference

12 December 2020

Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226

1 reference

12 December 2020

Molecular mechanisms of treg-mediated T cell suppression

1 reference

12 December 2020

The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development

1 reference

12 December 2020

An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas

1 reference

12 December 2020

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

1 reference

12 December 2020

T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development

1 reference

12 December 2020

TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77.

1 reference

12 December 2020

Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer

1 reference

12 December 2020

An obligate cell-intrinsic function for CD28 in Tregs

1 reference

12 December 2020

Molecular mechanisms of T cell co-stimulation and co-inhibition

1 reference

12 December 2020

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway

1 reference

12 December 2020

The influence of T cell Ig mucin-3 signaling on central nervous system autoimmune disease is determined by the effector function of the pathogenic T cells.

1 reference

12 December 2020

Blockade of programmed death-1 in young (New Zealand Black x New Zealand White)F1 mice promotes the suppressive capacity of CD4+ regulatory T cells protecting from lupus-like disease

1 reference

12 December 2020

Modulation of Treg cells/T effector function by GITR signaling is context-dependent

1 reference

12 December 2020

Depleting tumor-specific Tregs at a single site eradicates disseminated tumors

1 reference

12 December 2020

PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2

1 reference

12 December 2020

TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

1 reference

12 December 2020

Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals

1 reference

12 December 2020

Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules

1 reference

12 December 2020

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.

1 reference

12 December 2020

Treg and CTLA-4: two intertwining pathways to immune tolerance

1 reference

12 December 2020

Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.

1 reference

12 December 2020

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

1 reference

12 December 2020

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

1 reference

12 December 2020

The contextual role of TNFR family members in CD8(+) T-cell control of viral infections

1 reference

12 December 2020

CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-β.

1 reference

12 December 2020

Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells

1 reference

12 December 2020

Gene targeting in NOD mouse embryos using zinc-finger nucleases.

1 reference

12 December 2020

PD-1 blockage delays murine squamous cell carcinoma development.

1 reference

12 December 2020

Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response

1 reference

12 December 2020

Interleukin-2 and STAT5 in regulatory T cell development and function

1 reference

12 December 2020

Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells

1 reference

12 December 2020

CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients

1 reference

12 December 2020

Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines.

1 reference

12 December 2020

OX40 is a potent immune-stimulating target in late-stage cancer patients

1 reference

12 December 2020

BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection

1 reference

12 December 2020

Therapeutic polyclonal human CD8+ CD25+ Fox3+ TNFR2+ PD-L1+ regulatory cells induced ex-vivo

1 reference

12 December 2020

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

1 reference

12 December 2020

Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment

1 reference

12 December 2020

TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine

1 reference

12 December 2020

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

1 reference

12 December 2020

Efficacy and safety of abatacept in lupus nephritis: a twelve-month, randomized, double-blind study

1 reference

12 December 2020

Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes

1 reference

12 December 2020

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

1 reference

12 December 2020

OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy

1 reference

12 December 2020

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

1 reference

12 December 2020

LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses

1 reference

12 December 2020

Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells

1 reference

12 December 2020

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

1 reference

12 December 2020

Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy

1 reference

12 December 2020

PD-1 regulates extrathymic regulatory T-cell differentiation

1 reference

12 December 2020

Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity

1 reference

12 December 2020

Therapeutic blockade of LIGHT interaction with herpesvirus entry mediator and lymphotoxin β receptor attenuates in vivo cytotoxic allogeneic responses

1 reference

12 December 2020

Expansion of regulatory GITR+CD25 low/-CD4+ T cells in systemic lupus erythematosus patients

1 reference

12 December 2020

Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC.

1 reference

12 December 2020

Genetic basis for clinical response to CTLA-4 blockade in melanoma

1 reference

12 December 2020

The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function

1 reference

12 December 2020

TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit

1 reference

12 December 2020

Molecular underpinnings of Th17 immune-regulation and their implications in autoimmune diabetes

1 reference

12 December 2020

Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.

1 reference

12 December 2020

Effector T cells boost regulatory T cell expansion by IL-2, TNF, OX40, and plasmacytoid dendritic cells depending on the immune context

1 reference

12 December 2020

Confusing signals: recent progress in CTLA-4 biology

1 reference

12 December 2020

Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation

1 reference

12 December 2020

Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice

1 reference

12 December 2020

TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients

1 reference

12 December 2020

4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8+ T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling

1 reference

12 December 2020

OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response

1 reference

12 December 2020

Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential

1 reference

12 December 2020

4-1BB Agonists: Multi-Potent Potentiators of Tumor Immunity

1 reference

12 December 2020

TIGIT expression levels on human NK cells correlate with functional heterogeneity among healthy individuals

1 reference

12 December 2020

1 reference

12 December 2020

Regulatory T-Cell Development in the Human Thymus

1 reference

12 December 2020

Principles of antibody-mediated TNF receptor activation

1 reference

12 December 2020

LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model

1 reference

12 December 2020

1 reference

12 December 2020

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

1 reference

12 December 2020

TIGIT predominantly regulates the immune response via regulatory T cells.

1 reference

12 December 2020

Ovarian carcinoma-infiltrating regulatory T cells were more potent suppressors of CD8(+) T cell inflammation than their peripheral counterparts, a function dependent on TIM3 expression

1 reference

12 December 2020

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

1 reference

12 December 2020

Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways

1 reference

12 December 2020

Rationale for anti-OX40 cancer immunotherapy

1 reference

12 December 2020

GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis.

1 reference

12 December 2020

Identification of CD112R as a novel checkpoint for human T cells

1 reference

12 December 2020

1 reference

12 December 2020

Risk of endocrine complications in cancer patients treated with immune check point inhibitors: a meta-analysis.

1 reference

12 December 2020

Regulatory T Cells in Melanoma Revisited by a Computational Clustering of FOXP3+ T Cell Subpopulations.

1 reference

12 December 2020

CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm

1 reference

12 December 2020

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.

1 reference

12 December 2020

4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4+CD25+FoxP3+ T Regulatory Cell Suppression

1 reference

12 December 2020

Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

1 reference

12 December 2020

Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers

1 reference

12 December 2020

PD-L1 Expression Is Associated with Tumor FOXP3(+) Regulatory T-Cell Infiltration of Breast Cancer and Poor Prognosis of Patient

1 reference

12 December 2020

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.

1 reference

12 December 2020

The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses

1 reference

12 December 2020

Co-stimulatory and Co-inhibitory Pathways in Autoimmunity.

1 reference

12 December 2020

Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity.

1 reference

12 December 2020

Gut environment-induced intraepithelial autoreactive CD4(+) T cells suppress central nervous system autoimmunity via LAG-3.

1 reference

12 December 2020

Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice

1 reference

12 December 2020

Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis.

1 reference

12 December 2020

Management of side effects of immune checkpoint blockade by anti-CTLA-4 and anti-PD-1 antibodies in metastatic melanoma

1 reference

12 December 2020

Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model

1 reference

12 December 2020

Assessing Immune-Related Adverse Events of Efficacious Combination Immunotherapies in Preclinical Models of Cancer.

1 reference

12 December 2020

An essential role for the IL-2 receptor in Treg cell function

1 reference

12 December 2020

Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy

1 reference

12 December 2020

Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.

1 reference

12 December 2020

Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model.

1 reference

12 December 2020

Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility

1 reference

12 December 2020

Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling

1 reference

12 December 2020

A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist

1 reference

12 December 2020

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

1 reference

12 December 2020

TIGIT signalling pathway negatively regulates CD4+ T-cell responses in systemic lupus erythematosus

1 reference

12 December 2020

Tim-3 and its role in regulating anti-tumor immunity

1 reference

12 December 2020

Elevated serum autoantibodies against co-inhibitory PD-1 facilitate T cell proliferation and correlate with disease activity in new-onset systemic lupus erythematosus patients

1 reference

12 December 2020

Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment

1 reference

12 December 2020

Tim3+ Foxp3 + Treg Cells Are Potent Inhibitors of Effector T Cells and Are Suppressed in Rheumatoid Arthritis.

1 reference

12 December 2020

Immune Checkpoint Inhibitors: An Innovation in Immunotherapy for the Treatment and Management of Patients with Cancer

1 reference

12 December 2020

Regulatory T cells in multiple sclerosis and myasthenia gravis.

1 reference

12 December 2020

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice

1 reference

12 December 2020

PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells

1 reference

12 December 2020

TNFR2: A Novel Target for Cancer Immunotherapy

1 reference

12 December 2020

The Systemic Activation of Programmed Death 1-PD-L1 Axis Protects Systemic Lupus Erythematosus Model from Nephritis

1 reference

12 December 2020

Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies

1 reference

12 December 2020

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer.

1 reference

12 December 2020

Structural principles of tumor necrosis factor superfamily signaling

1 reference

12 December 2020

1 reference

12 December 2020

Immune checkpoint inhibitors in cancer therapy: a focus on T-regulatory cells

1 reference

12 December 2020

Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors

1 reference

12 December 2020

Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice.

1 reference

12 December 2020

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.

1 reference

12 December 2020

Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation.

1 reference

12 December 2020

10.1016/J.JAUT.2018.08.007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30174217%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30174217%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

PubMed publication ID

30174217

1 reference