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Denise Manahan-Vaughan

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Denise Manahan-Vaughan (born 17 May 1965)[1] is an Irish neuroscientist and neurophysiologist. She is head of the Department of Neurophysiology, dean of studies and director of the International Graduate School of Neuroscience and co-founder of the Research Department of Neuroscience (founded in 2008) of the Ruhr University Bochum. Her research focuses on elucidation of the cellular and synaptic mechanisms underlying the acquisition and long-term maintenance of associative memories. She uses a multidisciplinary approach to study how spatial experiences, sensory input, neuromodulation, or brain disease impacts on, and provide insight into, the function of the hippocampus in enabling long-term memory.

Background and education

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A native of Rathgar in Dublin, Ireland, she studied natural sciences at Trinity College Dublin, graduating with an honours degree, specialising in physiology in 1988. She completed a PhD in neuropharmacology/neurophysiology in 1992. In the mid-1990s she moved to Germany, working first as a research scientist at the Leibniz Institute for Neurobiology in Magdeburg, and completing a Habilitation degree in physiology at the Otto von Guericke University in 1998.

She became associate professor of physiology at the Johannes Müller Institute for Physiology at the Charité in Berlin where she established the Synaptic Plasticity Research Group. In 2003, she became professor of neuroscience at the Ruhr University Bochum, where she was head of the learning and memory research unit. At this time she also became dean of studies and director of the International Graduate School of Neuroscience.

In January 2008 she became chair of the Department of Experimental Neurophysiology and in October 2010, chair of the Department of Neurophysiology, within the medical faculty, of the Ruhr University Bochum.

She is a niece of the renowned Irish actress, Anna Manahan and of Irish civil servant Michael Manahan. The marine scientist Donal T. Manahan is her second cousin and her brother is geologist Alan P.M. Vaughan.[2][3]

Additional academic activities

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In 2017, she became executive director of the Institute of Physiology. She is currently speaker of the Collaborative Research Consortium on Integration and Representation of Sensory Processes (SFB 874) (founded in 2010) that is funded by the German Research Foundation and speaker of the Research Department of Neuroscience of the Ruhr University Bochum. She is currently also acting head of both the departments of cellular physiology and of systems physiology of the Institute of Physiology of the Ruhr University Bochum.

In 2010 she co-founded the Mercator Research Group on the Structure of Memory with the aim of creating a novel basis for research interactions and collaborations between neuroscientists, cognitive scientists, philosophers and computational neuroscientists at the Ruhr University Bochum. This initiative that was funded by the Stiftung Mercator created a number of tenure-track professorships that focus on multidisciplinary memory research and established a 7-Tesla small animal magnetic resonance imaging unit at the Ruhr University.

She is a member of the editorial board of NeuroForum and is an associate editor of both Frontiers in Behavioral Neuroscience and Frontiers in Integrative Neuroscience.

Roles in fostering the careers of young scientists, outreach, dissemination and gender equality

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Fostering early career development

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In 2003 she co-founded the Network of European Neuroscience Schools (NENS) with the goal of optimising and increasing the international visibility of European graduate programs and graduate schools in neuroscience. NENS was integrated into the Federation of European Neuroscience Societies] in 2005. She was chairperson of Network of European Neuroscience Schools (NENS)] in the period encompassing 2005–2010. She was a member of the executive committee and Governing Council of the Federation of European Neuroscience Societies from 2005 to 2010.

From 2005 through 2010, she was also speaker of the Competence Network for Neuroscience of the German Federal State of Northrhine Westphalia (NeuroNRW). The goal of the network was to enhance ideas exchange, collaborative interactions and research visibility of neuroscientists in Northrhine Westphalia.

Since 2009 she has hosted an annual 2-day international conference on memory and cognition for the International Graduate School of Neuroscience.

Outreach and dissemination

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She established and implements a variety of extensive outreach and dissemination strategies at the Ruhr University Bochum aimed at raising the awareness of school pupils, from junior school through senior school levels, to the possibility of pursuing an academic career in neuroscience[4] and at engaging the public and stakeholders with neuroscientific research and its findings.[5][6] These include Brain Day an annual event that offers lectures, interactive events and exchanges with patient representative groups, that is typically attended by over 400 members of the public, Brain Café and schools competitions.

She is a member of the executive board of RUBIN, the science outreach magazine of the Ruhr University Bochum.

In March 2019 she was elected to the Dana Alliance for Brain Initiatives.[7]

Strategies to optimise gender equality in neuroscience

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In April 2019 she founded NeuroNEXXT, a digital platform aimed to raise the international visibility, networking opportunities and gender equality of female neuroscientists, at all career levels.

Research

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Her research focusses on characterising the role that synaptic plasticity and neural information processing plays in spatial memory and associative memory formation in the mammalian brain. Within this context she also studies the etiology and early pathogenesis of both psychosis and Alzheimer's disease. Her methodology ranges from in vivo and in vitro electrophysiological approaches, including single cell, single unit, local field potential and EEG neural signal analysis, through optogenetics, neuropharmacology, wide-field calcium imaging and trans-species cognitive studies. She has produced over 145 international scientific publications on the area of hippocampal function and memory encoding in the mammalian brain.[8] Her findings with regard to the role of hippocampal long-term depression in memory processing[9][10] have contributed to a revised understanding as to how synaptic plasticity may contribute to information encoding and memory.

Selected works

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Books

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  • Manahan-Vaughan D, ed. (2018). Handbook of Neural Plasticity Techniques: a systems neuroscience approach to the neural basis of memory and cognition. Elsevier. ISBN 978-0-12-812028-6.

Book articles

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  • Manahan-Vaughan D (2018). "Item Encoding through hippocampal long-term potentiation and long-term depression.". In Ennaceur A, de Souza Silva MA (eds.). Handbook of Object Novelty Recognition. Elsevier. ISBN 978-0-12-812012-5.
  • Manahan-Vaughan D (2017). "Learning-Related Hippocampal Long-Term Potentiation and Long-Term Depression". Learning and Memory: A Comprehensive Reference. pp. 585–609. doi:10.1016/B978-0-12-809324-5.21104-8. ISBN 978-0-12-805291-4.
  • Hagena H, Manahan-Vaughan D (2017). "MGlu5: A Metabotropic Glutamate Receptor at the Hub of Hippocampal Information Processing, Persistent Synaptic Plasticity, and Long-Term Memory". MGLU Receptors. pp. 79–101. doi:10.1007/978-3-319-56170-7_5. ISBN 978-3-319-56168-4.

Journal articles

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References

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  1. ^ curriculum vitae
  2. ^ Petrunin AG, Rogozhina I, Vaughan AP, Kukkonen IT, Kaban MK, Koulakov I, Thomas M (September 2013). "Heat flux variations beneath central Greenland's ice due to anomalously thin lithosphere". Nature Geoscience. 6 (9): 746–750. Bibcode:2013NatGe...6..746P. doi:10.1038/ngeo1898.
  3. ^ Vaughan AP (1995). "Circum-Pacific mid-Cretaceous deformation and uplift: A superplume-related event?". Geology. 23 (6): 491. Bibcode:1995Geo....23..491V. doi:10.1130/0091-7613(1995)023<0491:CPMCDA>2.3.CO;2.
  4. ^ "Outreach SFB874 for pupils".
  5. ^ "Brain Day".
  6. ^ "Brain Café".
  7. ^ "Dana press release March 2019".
  8. ^ Search Results for author Manahan-Vaughan D on PubMed.
  9. ^ Manahan-Vaughan D, Braunewell KH (July 1999). "Novelty acquisition is associated with induction of hippocampal long-term depression". Proceedings of the National Academy of Sciences of the United States of America. 96 (15): 8739–44. Bibcode:1999PNAS...96.8739M. doi:10.1073/pnas.96.15.8739. PMC 17586. PMID 10411945.
  10. ^ Kemp A, Manahan-Vaughan D (May 2004). "Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition". Proceedings of the National Academy of Sciences of the United States of America. 101 (21): 8192–7. Bibcode:2004PNAS..101.8192K. doi:10.1073/pnas.0402650101. PMC 419579. PMID 15150407.
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