PTPRO

PTPRO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G59, 2GJT
Identifiers
Aliases	PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O, protein tyrosine phosphatase receptor type O
External IDs	OMIM: 600579; MGI: 1097152; HomoloGene: 21564; GeneCards: PTPRO; OMA:PTPRO - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	15,602,175 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	137,440,231 bp
RNA expression pattern
	Top expressed in
	glomerulus; ; metanephric glomerulus; ; rectum; ; ganglionic eminence; ; middle temporal gyrus; ; human kidney; ; ventricular zone; ; nucleus accumbens; ; prefrontal cortex; ; mucosa of transverse colon;
	Top expressed in
	renal corpuscle; ; arcuate nucleus; ; median eminence; ; olfactory bulb; ; barrel cortex; ; ventromedial nucleus; ; piriform cortex; ; mammillary body; ; dorsomedial hypothalamic nucleus; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; protein homodimerization activity; phosphatase activity; Wnt-protein binding; protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; hydrolase activity;
Cellular component	integral component of membrane; lateral plasma membrane; membrane; growth cone; plasma membrane; dendritic spine; integral component of plasma membrane; axon; apical plasma membrane; neuron projection; extracellular exosome; lamellipodium; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic density membrane;
Biological process	negative regulation of cell-substrate adhesion; negative regulation of neuron projection development; monocyte chemotaxis; negative regulation of retinal ganglion cell axon guidance; regulation of glomerular filtration; slit diaphragm assembly; protein dephosphorylation; glomerulus development; axon guidance; cell morphogenesis; glomerular visceral epithelial cell differentiation; peptidyl-tyrosine dephosphorylation; negative regulation of glomerular filtration; negative regulation of canonical Wnt signaling pathway; lamellipodium assembly; dephosphorylation; regulation of synapse organization;
	Sources:Amigo / QuickGO
Orthologs
	5800
	19277
	ENSG00000151490
	ENSMUSG00000030223
	Q16827
	E9Q612
NM_002848; NM_030667; NM_030668; NM_030669; NM_030670;
	NM_030671
	NM_001164401; NM_001164402; NM_001164403; NM_011216
NP_002839; NP_109592; NP_109593; NP_109594; NP_109595;
	NP_109596
	NP_001157873; NP_001157874; NP_001157875; NP_035346
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.^[5]^[6]^[7]

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151490 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030223 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J Biol Chem. 269 (31): 19953–62. doi:10.1016/S0021-9258(17)32113-0. PMID 7519601.
^ Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE (Oct 1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics. 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166.
^ ^a ^b "Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O".

Seimiya H, Sawabe T, Inazawa J, Tsuruo T (1995). "Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents". Oncogene. 10 (9): 1731–8. PMID 7753550.
Feito MJ, Bragardo M, Buonfiglio D, Bonissoni S, Bottarel F, Malavasi F, Dianzani U (1997). "gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules". Int. Immunol. 9 (8): 1141–7. doi:10.1093/intimm/9.8.1141. PMID 9263011.
Avraham S, London R, Tulloch GA, Ellis M, Fu Y, Jiang S, White RA, Painter C, Steinberger A (1998). "Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells". Gene. 204 (1–2): 5–16. doi:10.1016/S0378-1119(97)00420-4. PMID 9434160.
Taniguchi Y, London R, Schinkmann K, Jiang S, Avraham H (1999). "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor". Blood. 94 (2): 539–49. doi:10.1182/blood.V94.2.539. PMID 10397721.
Aguiar RC, Yakushijin Y, Kharbanda S, Tiwari S, Freeman GJ, Shipp MA (1999). "PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest". Blood. 94 (7): 2403–13. doi:10.1182/blood.V94.7.2403.419k39_2403_2413. PMID 10498613. S2CID 15259010.
Wang Z, Bhattacharya N, Meyer MK, Seimiya H, Tsuruo T, Tonani JA, Magnuson NS (2001). "Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells". Arch. Biochem. Biophys. 390 (1): 9–18. doi:10.1006/abbi.2001.2370. PMID 11368509.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chen L, Juszczynski P, Takeyama K, Aguiar RC, Shipp MA (2007). "Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation". Blood. 108 (10): 3428–33. doi:10.1182/blood-2006-03-013821. PMID 16888096.
Motiwala T, Majumder S, Kutay H, Smith DS, Neuberg DS, Lucas DM, Byrd JC, Grever M, Jacob ST (2007). "Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia". Clin. Cancer Res. 13 (11): 3174–81. doi:10.1158/1078-0432.CCR-06-1720. PMC 3074612. PMID 17545520.
Tian J, Wang HP, Mao YY, Jin J, Chen JH (2007). "Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy". J. Int. Med. Res. 35 (3): 338–45. doi:10.1177/147323000703500308. PMID 17593862. S2CID 24500200.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151490 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030223 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7519601-5] Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J Biol Chem. 269 (31): 19953–62. doi:10.1016/S0021-9258(17)32113-0. PMID 7519601.

[pmid7665166-6] Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE (Oct 1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics. 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166.

[entrez-7] "Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O".

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References

Further reading