The motivation for the track is generally accepted to be the troublesome relationship between Axl Rose and his now ex-wife Erin Everly, though this was never stated in the album or interviews. According to bass guitarist Duff McKagan, "Axl came up with a great lyric, seemingly out of nowhere, that of course became the story and melody of that song."[6]
Drummer Steven Adler did not record on the track, although in some live performances prior to release of the album, such as their performance at the Orange County Fair in New York in the summer of 1988, percussion (and electric instruments) were used.
In the video, the band members are situated in a hotel where they are the only constant images, as all other people are present for a moment, then fade away. Directed by Nigel Dick, it was one of the numerous videos produced by the band. The video was filmed on Valentine's Day during 1989, some scenes being shot at the Record Plant. It was the last video in which Steven Adler appeared (even though he did not play on the recorded track) and the last before the Use Your Illusion videos. Mike Clink is also featured in the video, sitting at the mixing board. The video was shot in The Ambassador Hotel, made famous due to Bobby Kennedy's assassination in 1968. The hotel was inoperative and scheduled for demolition, but was not demolished until 2006.
"Patience" has been a staple in Guns N' Roses' setlists on all tours since the song was released. When performed live, electric guitars are often used instead of acoustic. Despite the album version of the song featuring no drumming, the drummers make active use of their drum kits during performances, and keyboardist Dizzy Reed makes use of his keyboard as well. In the 21st century, the band's lead guitarist (Slash or DJ Ashba) would play electric guitar, while the second guitarist (Buckethead, Paul Tobias, Richard Fortus, Bumblefoot or Duff McKagan) would play acoustic. Live performances are available on Appetite for Democracy 3D and Made in Stoke 24/7/11.
The band performed the song live at the American Music Awards filmed at the Shrine Auditorium. Steven Adler was in rehab at the time of filming, and Don Henley filled in for him during the taping.