http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103951566-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3966ddee295e08cc6fcce4695c77f91b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-45 |
| filingDate | 2014-04-30^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-06-17^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_179a58cddf6923910cef72bb0ecc64bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8aa91fcfc519ff20c82fc5a774dd3e2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24dd2ea12380003c3e4208d8a0af3cca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_269f72c0bbb2f6cac9b741a397ef60ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5e84a41f6ed8b884dffc7885bce25c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81feabcb6457bcc84471163ec1b0f0c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_661d3e095cad675b442870fbc9d31ed7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16ba166fc28a8e09bbf1a64717e87b29 |
| publicationDate | 2015-06-17^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103951566-B |
| titleOfInvention | N-alkyl-1,2,3,4,5,6-hexahydro-1,1,5,5-tetramethyl-7H-2,4 alpha-methanonaphthalene-7-amine compound as well as synthetic method and application thereof |
| abstract | The invention discloses an N-alkyl-1,2,3,4,5,6-hexahydro-1,1,5,5-tetramethyl-7H-2,4 alpha-methanonaphthalene-7-amine compound as well as a synthetic method and an application thereof. Longifolene serving as a heavy oil main component is relatively rich terpenoid in numerous natural extracts. The synthetic method comprises the following steps: obtaining isolongifolene through longifolene isomerization, obtaining isolongifolenone through allylic oxidation of the isolongifolene, carrying out dehydration condensation on the isolongifolenone and primary amine so as to obtain imine and obtaining the chiral N-alkyl-1,2,3,4,5,6-hexahydro-1,1,5,5-tetramethyl-7H-2,4 alpha-methanonaphthalene-7-amine compound after reduction. The compound has vey good inhibition activity on candida albicans, aspergillus niger, candida tropicalis, escherichia coli, staphylococcus aureus, pseudomonas fluorescens, bacillus subtilis and the like, a part of compound has good cancer cell proliferation inhibition activity on human breast cancer cells MCF-7, human lung adenocarcinoma cells A549, hepatoma cells HepG2 and SMMC-7721, and the N-alkyl-1,2,3,4,5,6-hexahydro-1,1,5,5-tetramethyl-7H-2,4 alpha-methanonaphthalene-7-amine compound is a potential antibacterial and bactericidal and anti-tumor compound. |
| priorityDate | 2014-04-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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