| abstract |
Compounds of formula (I), and salts and prodrugs thereofn n wherein n Q is the residue of an optionally substituted azabicyclic ring system; n X represents oxa or thia; n Y represents H or hydroxy; n R¹ and R² independently represent phenyl or thienyl, either of which groups may be optionally substituted by halo or trifluoromethyl; n R³, R⁴ and R⁵ independently represent H, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, -OR a , SCH₃, SOCH₃, SO₂CH₃, -NR a R b , -NR a COR b , -NR a CO₂R b , -CO₂R a or -CONR a R b ; and n R a and R b independently represent H, C₁₋₆ alkyl, phenyl or trifluoromethyl, n are tachykinin antagonists. They and compositions thereof are therefore useful in therapy. |