| abstract |
The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and their medical use. n nwhereinn R represents the ring A n nor 2-pyridinyl or 2-pyridinyl-N-oxide;n R 1 is selected from halogen atoms and C 1-4 alkyl, C 1-4 alkoxy, trifluoromethyl, and S(O) n C 1-4 alkyl groups; R 2 and R 3 , which may be the same or different, each independently are selected from hydrogen and halogen atoms and C 1-4 alkyl, C 1-4 alkoxy, trifluoromethyl and cyano groups; n represents zero, 1 or 2;n nand pharmaceutically acceptable salts and solvates thereof. |