| abstract |
The present invention relates to the use of valproic acid andnderivatives thereof as an inhibitor of histone deacetylases. Theninvention also concerns the use of those compounds for the manufacturenof a medicament for the treatment of diseases associated with histonenhypoacetylation or in which a therapeutic effect can be achieved byninduction of increased histone acetylation, such as tumors or leukemias,nmyelodysplasic syndrome or thyroid resistance syndrome. Also providednare methods for screening compounds having histone deacetylase activitynusing valproic acid/derivative thereof, and methods for identifyingngenes induced by valproic acid/derivatives thereof. |