| abstract |
The present invention relates to antiemetic nasalnspray composition comprisingn (1) 2-8 parts by weight of ondansetron hydrochloride asnan antiemetic drug; and (2) 100 parts by weight of base material for nasalnadministration consisting of (i) 70-85% by weight of water,n(ii) 5-15% by weight of polyethylene glycol, (iii) 0.005-0.02%nby weight of benzalkonium chloride and (iv) 7-20% bynweight of one solubilizer selected from sulfobutyl ether β-cyclodextrinnsodium salt, dimethyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin,nthe total amount of the abovenbase material being 100% by weight. n The antiemetic composition according to the presentninvention is feasible for nasal administration, and rapidlynexerts its antiemetic effect within 30 minutes uponnadministering it to a human being. In addition, since nasalnbioavailability of ondansetron hydrochloride as an activeningredient is highly improved, the required effect can benattained even by administering relatively small amount ofnthe active ingredient. |