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filingDate 2006-09-26^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2009-03-12^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2009509979-A
titleOfInvention Compositions and methods for granzyme B inhibition
abstract The present invention relates to the discovery that serpin a3n, a secreted protein, binds to granzyme B and inhibits its activity. The present invention thus provides a cell comprising a polynucleotide encoding a granzyme B inhibitory serpin, a pharmaceutical composition comprising a granzyme B inhibitory serpin or a polynucleotide encoding a granzyme B inhibitory serpin, granzyme B inhibitory Methods are provided for treating patients in need of immunosuppression by administering serpins, and methods for transplanting cells (eg, islet cells) that express granzyme B inhibitory serpins.
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type http://data.epo.org/linked-data/def/patent/Publication

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