| abstract |
(57) [Summary]nThe present invention provides an analog of alpha-1-antichymotrypsin, wherein the amino acid at position 358 is selected from the group consisting of methionine, isoleucine, valine, alanine, aspartic acid, threonine and glutamic acid. The alpha-1-antichymotrypsin analogs of the present invention are effective inhibitors of human neutrophil elastase. The invention also provides nucleic acid sequences encoding the analogs, expression vectors, transformed host cells, and methods of making these analogs. |