| abstract |
NEW MATERIAL:A piperazine derivative shown by the formula (R is H, alkyl, allyl, aryl, aralkyl; X is CH 2 , O; Y is CN, N) or piperidine derivative and its acid addition salt. n EXAMPLE: 4-Benzyl-1-(1-isochromanyl)piperidine. n USE: An antiallergic. Suppressing the liberation of a chemical transmitter substance from a mastocyte or a basophil. Effective for preventing and remedying bronchial asthma, allergic rhinitis, etc. n PROCESS: A piperidine derivative or a piperazine derivative is reacted with a given isochroman derivative or a tetraline derivative, to give a compound shown by the formula. n COPYRIGHT: (C)1982,JPO&Japio |